公开(公告)号：US20210121533A1

公开(公告)日：2021-04-29

申请号：US16497117

申请日：2018-03-30

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli

IPC分类号： A61K38/20 ,  A61P1/04 ,  A61M31/00 ,  C07K14/54

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with IL-10 or an IL-10 agonist.

公开(公告)号：US20210038872A1

公开(公告)日：2021-02-11

申请号：US17024176

申请日：2020-09-17

申请人： Progenity, Inc.

发明人： Jeffrey A. Shimizu ,  Mitchell Lawrence Jones ,  Mark Sasha Drlik ,  Iman Niknia ,  Nathan John Muller ,  Tuyen Nguyen ,  Christopher Loren Wahl ,  Edward Mudge ,  Nicholas Mark Salt ,  Nia Eleri Stevens ,  Stuart Robert Abercrombie ,  Christopher Ian Bunce ,  Nelson Quintana

IPC分类号： A61M31/00

摘要： An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

公开(公告)号：US20210031012A1

公开(公告)日：2021-02-04

申请号：US16964281

申请日：2019-01-24

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli ,  Kevin David Howe ,  Aruna Perera

IPC分类号： A61M31/00 ,  A61P1/00 ,  A61K9/00 ,  A61K31/519

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a PDE4 inhibitor.

公开(公告)号：US20200323772A1

公开(公告)日：2020-10-15

申请号：US16639082

申请日：2018-08-13

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Christopher Loren Wahl ,  Sharat Singh

IPC分类号： A61K9/00 ,  C07K16/28 ,  A61K9/48 ,  A61P29/00 ,  C07K16/24 ,  A61K38/13 ,  A61P1/00 ,  A61K31/436

摘要： This disclosure features methods and compositions for treating inflammatory disorders or conditions that arise in a tissue originating from the endoderm using an immune modulator.

公开(公告)号：US20200253506A1

公开(公告)日：2020-08-13

申请号：US16467744

申请日：2017-12-14

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli

IPC分类号： A61B5/07 ,  A61K38/13 ,  A61K39/395 ,  A61K9/00 ,  C07K16/24 ,  C07K16/28 ,  C12N15/113 ,  A61B10/00 ,  A61B5/00

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an integrin inhibitor. In an exemplary embodiment, a pharmaceutical formulation that comprises the medicaments is released from an ingestible device at a location in the gastrointestinal tract that is proximate to one or more sites of disease.

公开(公告)号：US20200032344A1

公开(公告)日：2020-01-30

申请号：US16596118

申请日：2019-10-08

申请人： Progenity, Inc.

发明人： Tobias Mann ,  Heng Wang ,  Jung H. Kim ,  Matthew Sekedat

IPC分类号： C12Q1/6883 ,  C12Q1/6811 ,  C12Q1/6827 ,  G16B25/00 ,  G16B30/00 ,  G16H50/20 ,  C12Q1/6816

摘要： Methods and nucleic acid molecules for detecting chromosomal abnormalities such as aneuploidy. Methods for selecting nucleic acid molecules for use in the methods of the disclosure.

公开(公告)号：US10465245B2

公开(公告)日：2019-11-05

申请号：US15224463

申请日：2016-07-29

申请人： Progenity, Inc.

发明人： Tobias Mann ,  Heng Wang ,  Jung H. Kim ,  Matthew Sekedat

IPC分类号： C12Q1/6883 ,  G16B25/00 ,  G16B30/00 ,  C12Q1/6811 ,  C12Q1/6827 ,  G16H50/20 ,  C12Q1/6816

摘要： Methods and nucleic acid molecules for detecting chromosomal abnormalities such as aneuploidy. Methods for selecting nucleic acid molecules for use in the methods of the disclosure.

公开(公告)号：US20190309352A1

公开(公告)日：2019-10-10

申请号：US16461211

申请日：2017-11-16

申请人： Progenity, Inc

发明人： Jeffrey Buis ,  Ronald David Beaubien, JR. ,  Jay Stoerker

IPC分类号： C12Q1/6827 ,  C12Q1/6858 ,  C12Q1/6806

摘要： The invention provides methods for determining whether a subject is predisposed to the disease or condition, or for diagnosing a disease or condition, or for detecting the state of a disease or condition, by detecting nucleic acid fragment size patterns, copy number variations, mutational landscape, genomic instability, methylation status, and combinations thereof in a subject. The invention further provides methods for selecting nucleic acid molecules for use in the methods of the invention.

公开(公告)号：US20180206726A1

公开(公告)日：2018-07-26

申请号：US15835292

申请日：2017-12-07

申请人： Progenity Inc.

发明人： Sharat Singh ,  Mitchell Lawrence Jones

IPC分类号： A61B5/00 ,  G01N33/58 ,  A61K49/00

摘要： The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

公开(公告)号：US20180168489A1

公开(公告)日：2018-06-21

申请号：US15844381

申请日：2017-12-15

申请人： Progenity Inc.

发明人： Ryan Elliott Jones ,  Hamilton Roger Tang ,  Rachel Ellen Gerver ,  Mitchell Lawrence Jones ,  Sharat Singh

IPC分类号： A61B5/1459 ,  A61B5/07 ,  A61B5/145 ,  A61B5/00 ,  A61B1/04 ,  A61M31/00 ,  A61B1/00 ,  A61B5/1455

摘要： An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.