公开(公告)号：US20190309352A1

公开(公告)日：2019-10-10

申请号：US16461211

申请日：2017-11-16

申请人： Progenity, Inc

发明人： Jeffrey Buis ,  Ronald David Beaubien, JR. ,  Jay Stoerker

IPC分类号： C12Q1/6827 ,  C12Q1/6858 ,  C12Q1/6806

摘要： The invention provides methods for determining whether a subject is predisposed to the disease or condition, or for diagnosing a disease or condition, or for detecting the state of a disease or condition, by detecting nucleic acid fragment size patterns, copy number variations, mutational landscape, genomic instability, methylation status, and combinations thereof in a subject. The invention further provides methods for selecting nucleic acid molecules for use in the methods of the invention.