公开(公告)号：US06194543B1

公开(公告)日：2001-02-27

申请号：US09096411

申请日：1998-06-11

Applicant: Alexander T. Florence ,  Thiagarajan Sakthivel ,  Andrew F. Wilderspin ,  Istvan Toth

Inventor： Alexander T. Florence ,  Thiagarajan Sakthivel ,  Andrew F. Wilderspin ,  Istvan Toth

IPC: A61K3804

CPC classification number: C07K14/001 ,  A61K38/00 ,  A61K47/642

Abstract: A dendritic compound comprises two dendrons, each comprising dendritically linked amino acid units, preferably lysine units, joined to a focal group. One of the dendrons includes terminal branches including anchor groups constituted by hydrophobic units and the second dendron has terminal branches which are linked or may be linked to active ligands or sugar moieties. Methods for synthesising the dendritic compounds using solid phase peptide synthetic techniques including lipidic amino acid reagents is described. The compounds serve as a basis for multiple antigenic peptides or drug delivery systems.

Abstract translation: 树枝状化合物包含两个枝状突起，每个树突状结构包含连接到聚焦基团的树枝状连接的氨基酸单元，优选赖氨酸单元。 树突中的一个包括末端分支，包括由疏水单元构成的锚定基团，第二个树突具有连接或可连接到活性配体或糖部分的末端分支。 描述了使用包含脂质氨基酸试剂的固相肽合成技术合成树枝状化合物的方法。 该化合物作为多种抗原肽或药物递送系统的基础。

公开(公告)号：US4867288A

公开(公告)日：1989-09-19

申请号：US187490

申请日：1988-04-28

Applicant: Sandor Simonyi ,  Laszlo Torocsik ,  Istvan Toth ,  Gyorgy Valoczi

Inventor： Sandor Simonyi ,  Laszlo Torocsik ,  Istvan Toth ,  Gyorgy Valoczi

IPC: B60K31/00 ,  B60T8/72 ,  B60T10/02 ,  B60T13/58 ,  B60T13/66

CPC classification number: B60T10/02 ,  B60T13/585 ,  B60T13/66 ,  B60T8/72 ,  Y10T477/813 ,  Y10T477/816 ,  Y10T477/88

Abstract: The invention relates to a process for the actuation of an hydrodynamic retarder brake for motor vehicles, which is controlled by an electrohydraulic valve system. The rotational velocity of some part of the drive system (or an average of a plurality thereof) is indicated by a continuously generated electrical signal. When the throttle is released, or the brake pedal, having been depressed is then released, the vehicle velocity at that moment is stored as a reference signal in a memory. If the actual velocity thereafter exceeds the stored value, the hydrodynamic retarder is actuated. The momentary velocity of the vehicle is thereafter continuously compared with the stored reference velocity, and the retarder controlled accordingly. Rapidly applied retarder action is realized by controlling the same using PD control.

Abstract translation: 本发明涉及一种用于机动车辆的液力缓速制动器的致动过程，该制动器由电动液压阀系统控制。 驱动系统的一部分（或其多个的平均值）的旋转速度由连续产生的电信号指示。 当节气门被释放或已经被按下的制动踏板然后被释放时，该时刻的车速被作为参考信号存储在存储器中。 如果此后的实际速度超过存储值，则启动流体动力学延迟器。 此后，车辆的瞬时速度与存储的基准速度持续比较，并且相应地控制延迟器。 通过使用PD控制对其进行控制来实现快速应用的减速器动作。

公开(公告)号：US4787933A

公开(公告)日：1988-11-29

申请号：US65265

申请日：1987-06-22

Applicant: Katalin Gorog nee Privitzer ,  Maria Kocsis nee Bagyi ,  Gyorgy Orosz ,  Tamas Torok ,  Istvan Laszlo ,  Laszlo Kondar ,  Istvan Toth ,  Karoly Balogh ,  Tibor Bodi ,  Erzsebet Grega nee Toth ,  Zsolt Dombay ,  Jozsef Nagy ,  Csaba Pavliscsak

Inventor： Katalin Gorog nee Privitzer ,  Maria Kocsis nee Bagyi ,  Gyorgy Orosz ,  Tamas Torok ,  Istvan Laszlo ,  Laszlo Kondar ,  Istvan Toth ,  Karoly Balogh ,  Tibor Bodi ,  Erzsebet Grega nee Toth ,  Zsolt Dombay ,  Jozsef Nagy ,  Csaba Pavliscsak

IPC: A01N25/32 ,  A01N37/34 ,  A01N47/30 ,  A01P13/00

CPC classification number: A01N25/32

Abstract: The invention relates to a herbicide composition comprising as herbicidally active ingredient an urea derivative and/or a thiolcargamate derivative and/or a chloroacetanilide derivative together with a nitrile derivative of the general formula (I), ##STR1## wherein R.sub.1 and R.sub.2 which are the same or different, stand for hydroger, halogen or a methyl, ethyl, allyl, vinyl, phenyl or benzyl group; orR.sub.1 and R.sub.2 together may stand for a benzylidene group; andR.sub.3 means chlorine or a methyl, phenyl, chlorophenyl, alkoxyphenyl, chlorophenylamino, anilino, anilinomethylene, N-alkylanilinomethylene, N,N-dialkylanilinomethylene, alkoxyanilinomethylene, benzylaminomethylene, cyclohexylaminomethylene, N-alkyl-cyclohexylaminomethylene, hexamethyleniminomethylene, phthalimidomethylene, nitrophthalimidomethylene, morpholinomethylene, piperidinomethylene, C.sub.1-3 alkylaminomethylene, allylaminomethylene or di(C.sub.1-3 alkyl)aminorethylene groupand/or together with a cyanopyridine and/or with a benzonitrile derivative optionally mono- or polysubstituted by halogen(s) or C.sub.1-3 alkoxy group(s) as antidote(s) in a mass ratio from 40:1 to 1:1 of the herbicidally active ingredient to the antidote nitrile derivative.

Abstract translation: 本发明涉及一种除草剂组合物，其包含作为除草活性成分的尿素衍生物和/或硫氰酸酯衍生物和/或氯代乙酰苯胺衍生物以及通式（I）的腈衍生物，其中R1和R2 氢原子，卤素或甲基，乙基，烯丙基，乙烯基，苯基或苄基;它们相同或不同。 或者R 1和R 2可以一起代表亚苄基; 并且R 3表示氯或甲基，苯基，氯苯基，烷氧基苯基，氯苯基氨基，苯胺基，苯胺基亚甲基，N-烷基苯胺基亚甲基，N，N-二烷基苯胺基亚甲基，烷氧基亚氨基亚甲基，苄基亚氨基亚甲基，环己基氨基亚甲基，N-烷基 - 环己基亚氨基亚甲基，六亚甲基亚氨基亚甲基，邻苯二甲酰亚胺亚甲基，硝基邻苯二甲酰亚甲基，吗啉代亚甲基， 哌啶亚甲基，C 1-3烷基氨基亚甲基，烯丙基氨基亚甲基或二（C 1-3烷基）氨基亚乙基和/或与氰基吡啶和/或与任选被卤素或C 1-3烷氧基单取代或多取代的苄腈衍生物一起作为 解毒剂与除草剂腈衍生物的除草活性成分的质量比为40:1-1:1。

公开(公告)号：US4549026A

公开(公告)日：1985-10-22

申请号：US353872

申请日：1982-03-02

Applicant: Michel Deur ,  Istvan Toth

Inventor： Michel Deur ,  Istvan Toth

IPC: C07D249/18 ,  C07D249/20

CPC classification number: C07D249/18

Abstract: A process for the preparation of condensed triazoles of formula I ##STR1## in which R together with the triazole group form an aromatic group R.sub.1 is hydrogen or a hydrocarbon groupthe process comprisingreacting in a medium containing an organic phase a compound of formula II ##STR2## with a nitrite and an acid. The reaction is preferably carried out at a raised temperature.

Abstract translation: 制备式I的缩合三唑的方法其中R与三唑基一起形成芳族基团R 1是氢或烃基，该方法包括在含有机相的介质中使式II化合物 具有亚硝酸盐和酸的“IMAGE”II。 反应优选在升高的温度下进行。

公开(公告)号：US4342871A

公开(公告)日：1982-08-03

申请号：US744608

申请日：1976-11-24

Applicant: Csaba Szantay ,  Lajos Szabo ,  Laszlo Toke ,  Istvan Toth ,  Sandor Virag ,  Erzsebet Kanyo ,  Agoston David

Inventor： Csaba Szantay ,  Lajos Szabo ,  Laszlo Toke ,  Istvan Toth ,  Sandor Virag ,  Erzsebet Kanyo ,  Agoston David

IPC: C07D455/06 ,  C07D491/056 ,  C07D491/14 ,  C07D455/03 ,  A61K31/47

CPC classification number: C07D491/14 ,  C07D455/06

Abstract: An antiphlogistic compound of the formula (I) ##STR1## or a pharmaceutically effective salt thereof wherein R.sup.1 and R.sup.2 are hydrogen or C.sub.1-4 alkoxy or together form a methylenedioxy group;R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are hydrogen or a group of the formula --CH.sub.2 --(CH.sub.2).sub.n -R.sup.7 with the proviso that at least one of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is other than hydrogen;R.sup.7 is a carboxylic group or a carboxylic acid derivative group; n=0, 1 or 2, provided that if R.sup.3, R.sup.4 and R.sup.5 are hydrogen and R.sup.7 in the group R.sup.6 is cyano or alkoxycarbonyl, and n=1, then R.sup.1 and R.sup.2 are hydrogen, C.sub.2-4 alkoxy, or together form a methylenedioxy group.

Abstract translation: 式（I）的消炎化合物（I）或其药学上有效的盐，其中R 1和R 2是氢或C 1-4烷氧基或一起形成亚甲二氧基; R3，R4，R5和R6是氢或式-CH2-（CH2）n-R7的基团，条件是R3，R4，R5和R6中的至少一个不是氢; R7是羧基或羧酸衍生物基团; n = 0,1或2，条件是如果R3，R4和R5是氢，R6中的R7是氰基或烷氧基羰基，n = 1，则R1和R2是氢，C2-4烷氧基或一起形成 亚甲二氧基。

公开(公告)号：US4086246A

公开(公告)日：1978-04-25

申请号：US682033

申请日：1976-04-30

Applicant: Geza Toth ,  Istvan Toth ,  Tibor Montay

Inventor： Geza Toth ,  Istvan Toth ,  Tibor Montay

IPC: C07C275/30 ,  C07C67/00 ,  C07C239/00 ,  C07C271/08 ,  C07C273/02 ,  C07C273/18 ,  C07C275/40 ,  C07D235/32 ,  C07D277/28 ,  C07D307/86 ,  C07D317/24 ,  C07D307/87

CPC classification number: C07D235/32 ,  C07C273/1809 ,  C07D307/86 ,  C07D317/24

Abstract: A process for the preparation of a compound of the formula: ##STR1## wherein R.sup.1 is alkyl, alkyl substituted by halogen, alkyl substituted by alkoxy, aryl, aryl substituted by halogen, aryl substituted by alkyl, aryl substituted by alkoxy, aralkyl, aralkyl substituted by alkoxy, cycloalkyl, cycloalkyl substituted by halogen, cycloalkyl substituted by alkyl or cycloalkyl substituted by alkoxy, andR.sup.2 is an aromatic group, an aromatic group substituted by alkyl, an aromatic group substituted by halogen, an aromatic group substituted by alkoxy, a heteroaromatic group, a heteroaromatic group substituted by alkyl, a heteroaromatic group substituted by halogen, or a heteroaromatic group substituted by alkoxy, by the reaction of phosgene with a phenol of the formula:R.sup.2 -OHand further by the reaction of a primary amine of the formula:R'--NH.sub.2,reacting all three of the abovementioned reactants solution in a common water-immiscible organic solvent in the same reaction vessel at the same time in the presence of an acid binding agent to yield the compound of formula ##STR2##

Abstract translation: 一种制备下式化合物的方法：其中R1是烷基，被卤素取代的烷基，被烷氧基取代的烷基，芳基，被卤素取代的芳基，被烷基取代的芳基，被烷氧基取代的芳基，芳烷基，芳烷基 被烷氧基取代的环烷基，被烷基取代的环烷基或被烷氧基取代的环烷基，R2是芳基，被烷基取代的芳基，被卤素取代的芳基，被烷氧基取代的芳基， 杂芳基，被烷基取代的杂芳基，被卤素取代的杂芳基或被烷氧基取代的杂芳基，通过光气与下式的苯酚反应：

公开(公告)号：US4012426A

公开(公告)日：1977-03-15

申请号：US327621

申请日：1973-01-29

Applicant: Istvan Toth

Inventor： Istvan Toth

IPC: C07C205/47 ,  C07C20060101 ,  C07C67/00 ,  C07C201/00 ,  C09B1/00 ,  C09D1/00

Abstract: This invention provides a purification process for crude 1-nitroanthraquinone which comprises treating the crude 1-nitroanthraquinone with a base or a basic hydrolyzable salt, in the presence of a solvent and at an elevated temperature, and isolating the purified 1-nitroanthraquinone. The process particularly removes substantial proportions of dinitroanthraquinones and oxidation products.

Abstract translation: 本发明提供粗制1-硝基蒽醌的纯化方法，其包括在溶剂存在下和在升高的温度下用碱或碱式可水解盐处理粗1-硝基蒽醌，并分离纯化的1-硝基蒽醌。 该方法特别去除了相当大比例的二硝基蒽醌和氧化产物。