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公开(公告)号：US08718881B2
公开(公告)日：2014-05-06
申请号：US13319105
申请日：2009-09-11
申请人： Paul S. Bixel , Marcelo Andres Lara
发明人： Paul S. Bixel , Marcelo Andres Lara
IPC分类号： H02P25/30
摘要： A system and method for efficiently regulating the fuel consumption of a variable speed combustion engine used to control loads such as a hoist motor in a mobile gantry crane based on load motor speed commands issued by a crane operator. The system and method can rely on a programmable logic controller to issue engine fuel commands to regulate engine speed based on interpolations derived from data representing the relationship between load motor voltage and engine speed and data representing the relationship between engine speed and engine power capacity. The method may also be used in modified form by combustion engines which need digital fixed speed commands.
摘要翻译： 一种用于根据起重机操作者发出的负载电动机速度指令，有效地调节用于控制诸如起重电动机等起重电动机的负载的变速内燃机的燃料消耗的系统和方法。 该系统和方法可以依赖于可编程逻辑控制器来发布发动机燃料命令以基于从表示负载电动机电压和发动机转速之间的关系的数据和表示发动机转速和发动机功率容量之间的关系的数据导出的内插来调节发动机转速。 该方法也可以以需要数字固定速度命令的内燃机以改进形式使用。
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公开(公告)号：US11534122B2
公开(公告)日：2022-12-27
申请号：US14429835
申请日：2013-09-20
申请人： Ge Wang , Guohua Cao
发明人： Ge Wang , Guohua Cao
摘要： The present invention provides stationary CT architecture for imaging at a faster temporal resolution and lower radiation dose. In embodiments, the architecture features stationary distributed x-ray sources and rotating x-ray detectors. Provided is a stationary source computed tomography (CT) architecture comprising: a detector disposed on a rotatable gantry; an x-ray source disposed on a fixed ring; wherein the detector is disposed on the gantry in a manner such that the detector is capable of rotating around a subject and of receiving a signal from the x-ray source. Embodiments of the invention include a CT-MRI scanner comprising the stationary CT architecture.
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公开(公告)号：US11406820B2
公开(公告)日：2022-08-09
申请号：US16520901
申请日：2019-07-24
IPC分类号： A61B18/12 , A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
摘要： A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US10537379B2
公开(公告)日：2020-01-21
申请号：US15843888
申请日：2017-12-15
摘要： The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
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公开(公告)号：US10448989B2
公开(公告)日：2019-10-22
申请号：US13332133
申请日：2011-12-20
摘要： The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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公开(公告)号：US10350223B2
公开(公告)日：2019-07-16
申请号：US15555527
申请日：2016-03-03
申请人： Richard W. Yee , Kenneth Hughes
发明人： Richard W. Yee , Kenneth Hughes
IPC分类号： A61K9/00 , A61K45/06 , A61K47/10 , A61K47/38 , A61K31/136 , A61K31/145 , A61K31/585
摘要： The compositions and methods disclosed herein provide for treatments of ocular disorders of the eye, such as ocular surface diseases as well as those associated with inflammation of internal cells and cell layers of the eye. The methods disclosed herein describe methods for treating ocular disorders, particularly dry eye disorders, comprising topically administering to an ocular region of a subject a composition comprising a pharmaceutically effective amount of at least one aldosterone antagonist or salt thereof and a pharmaceutically acceptable carrier. Included is a method for treating dry eye comprising topically administering to an ocular region of a subject a composition comprising spironolactone and hydroxypropyl methylcellulose; and reducing or preventing one or more symptoms or causes of dry eye.
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公开(公告)号：US10292755B2
公开(公告)日：2019-05-21
申请号：US15186653
申请日：2016-06-20
摘要： The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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公开(公告)号：US09643279B2
公开(公告)日：2017-05-09
申请号：US14926447
申请日：2015-10-29
CPC分类号： B23K20/1215 , B22F2998/00 , B23K20/1205 , B23K20/1245 , B23K20/1255 , B23K20/1275 , B23K20/128 , B29C41/36 , C23C24/045 , C23C24/06 , C23C26/00 , C22C32/00 , C22C29/00
摘要： The present invention relates to tooling and methods for disposing, coating, building up, repairing, or otherwise modifying the surface of a metal substrate using frictional heating and compressive loading of a consumable metal material against the substrate. Embodiments of the invention include friction-based fabrication tooling comprising a non-consumable member with a throat and a consumable member disposed in the throat, wherein the throat is operably configured such that during rotation of the non-consumable member at a selected speed, the throat exerts normal forces on and rotates the consumable member at the selected speed; and comprising means for dispensing the consumable member through the throat and onto a substrate using frictional heating and compressive loading. Embodiments of the invention also include fabrication methods using the tools described herein.
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公开(公告)号：US09642371B2
公开(公告)日：2017-05-09
申请号：US14528188
申请日：2014-10-30
申请人： John G. Jelesko , Matthew Kasson
发明人： John G. Jelesko , Matthew Kasson
CPC分类号： A01N63/04
摘要： Provided are methods and compositions for controlling at least one plant. Methods and compositions can comprise at least one strain of Colletotrichum spp., such as Colletotrichum fioriniae TR-123, Colletotrichum fioriniae TR-126, and combinations thereof. Methods and compositions of the invention are useful, for example, for controlling Toxicodendron radicans and/or Schinus terebinthifolus.
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公开(公告)号：US09198733B2
公开(公告)日：2015-12-01
申请号：US12906923
申请日：2010-10-18
申请人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
发明人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
CPC分类号： C12N13/00 , A61B34/10 , A61B2018/00613 , A61B2034/104 , A61B2034/105 , A61N1/0412 , G16H50/50
摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
摘要翻译： 本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。 实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。 本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。
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