公开(公告)号：US4938959A

公开(公告)日：1990-07-03

申请号：US239340

申请日：1988-08-30

Applicant: Henri A. Martin ,  Maurice Carraz ,  Rene Mallein ,  Georges S. Grimberg

Inventor： Henri A. Martin ,  Maurice Carraz ,  Rene Mallein ,  Georges S. Grimberg

IPC: A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K31/175 ,  A61K31/31 ,  A61K31/395 ,  A61K31/43 ,  A61K31/56 ,  A61K31/70 ,  A61K38/00 ,  A61K47/00 ,  A61P27/16

CPC classification number: A61K9/0046 ,  A61K31/70 ,  A61K9/10 ,  A61K9/14

Abstract: An ear powder and/or drop, containing soluble substances and an insoluble substance which will be spread of the mucous membrane and form a deposit which will act by its physical acitivity as a dilution support for powder active principles and as a sponge for drops.

Abstract translation: 耳粉和/或滴，含有可溶性物质和不溶性物质，其将被粘膜扩散并形成沉积物，其沉积物将通过其物理活性作为粉末活性成分的稀释载体和作为水滴的海绵。

公开(公告)号：US4633014A

公开(公告)日：1986-12-30

申请号：US628240

申请日：1984-07-06

Applicant: Gunar A. Bremanis ,  Ivars Y. Kalvinsh ,  Irene B. Antsena ,  Edmund Y. Lukevits ,  Maris M. Veveris ,  Valeryans Y. Kauss ,  Peter T. Trapentsier ,  Edvards E. Liepinsh

Inventor： Gunar A. Bremanis ,  Ivars Y. Kalvinsh ,  Irene B. Antsena ,  Edmund Y. Lukevits ,  Maris M. Veveris ,  Valeryans Y. Kauss ,  Peter T. Trapentsier ,  Edvards E. Liepinsh

IPC: A61K31/16 ,  A61K31/15 ,  A61K31/165 ,  A61K31/17 ,  A61K31/175 ,  A61K31/19 ,  A61K31/195 ,  A61K31/205 ,  A61K31/215 ,  A61K31/22 ,  A61K31/27 ,  A61K31/275 ,  A61K31/31 ,  A61P9/06 ,  C07C67/00 ,  C07C239/00 ,  C07C241/00 ,  C07C243/26 ,  C07C243/28 ,  C07C243/30 ,  C07C243/34 ,  C07C243/36 ,  C07C243/38 ,  C07C253/00 ,  C07C255/66 ,  C07C281/02 ,  C07C281/06 ,  C07C325/00 ,  C07C327/00 ,  C07C327/06 ,  C07C327/22 ,  C07C327/40 ,  C07C333/02 ,  C07C337/00 ,  C07C337/06 ,  C07C157/05 ,  C07C127/15 ,  C07C127/17 ,  C07C127/19 ,  C07C133/02 ,  C07C153/057 ,  C07C157/07 ,  C07C157/09

CPC classification number: C07C243/00 ,  C07C243/38 ,  C07C255/00

Abstract: Substituted 3-hydrazinopropionates comprising compounds of the general fola: ##STR1## wherein R.sup.1, R.sup.2 =H, an alkyl, a substituted alkyl, hydroxycarbonyl, alkoxycarbonyl, an aryl, an aralkyl, an unsaturated alkyl, a substituted aryl or a substituted aralkyl: ##STR2## wherein R.sup.7, R.sup.8 =H, an alkyl, an unsaturated alkyl, an aralkyl, an aryl, a substituted alkyl,R.sup.9 =OH, an alkoxy, an aralkoxy, an alkyl, an unsaturated alkyl, an aryl, a substituted aryl, an aralkyl;R.sup.4 is --C.tbd.N, --COR.sup.10, wherein R.sup.10 =OR.sup.11, NR.sup.12 R.sup.13, where R.sup.11 is H, an alkyl, an aralkyl and an alkali metal, R.sup.11 and R.sup.12 are each H, an alkyl, an aralkyl, an aryl;R.sup.5, R.sup.6 = an alkyl, an aryl, an aralkyl.

Abstract translation: 其中R1，R2 = H，烷基，取代的烷基，羟基羰基，烷氧基羰基，芳基，芳烷基，不饱和烷基，取代的芳基或取代的芳烷基的取代的3-肼基丙酸酯： 其中R7，R8 = H，烷基，不饱和烷基，芳烷基，芳基，取代烷基，R9 = OH，烷氧基，芳烷氧基，烷基，不饱和烷基，芳基，取代芳基 ，芳烷基; R4是-C3NN，-COR10，其中R10 = OR11，NR12R13，其中R11是H，烷基，芳烷基和碱金属，R11和R12各自为H，烷基，芳烷基，芳基; R5，R6 =烷基，芳基，芳烷基。

公开(公告)号：US4297368A

公开(公告)日：1981-10-27

申请号：US920166

申请日：1978-06-29

Applicant: Carmelo Gandolfi ,  Carlo Passarotti ,  Alessandro Andreoni ,  Angelo Fumagalli ,  Franco Faustini ,  Roberto Ceserani ,  Maria M. Usardi

Inventor： Carmelo Gandolfi ,  Carlo Passarotti ,  Alessandro Andreoni ,  Angelo Fumagalli ,  Franco Faustini ,  Roberto Ceserani ,  Maria M. Usardi

IPC: A61K31/31 ,  A61K31/41 ,  A61P43/00 ,  C07C405/00 ,  C07D307/935 ,  C07D307/937 ,  C07D407/12

CPC classification number: C07D307/937 ,  C07C405/00 ,  Y10S514/822 ,  Y10S514/826 ,  Y10S514/926 ,  Y10S514/927 ,  Y10S514/929

Abstract: Bicyclic prostaglandins and pharamaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory, anti-aggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds and compositions are also disclosed.

Abstract translation: 含有它们的双环前列腺素和含有它们的药物和兽药组合物具有许多药物或兽医用途，包括例如降血压，血管舒张，抗聚集，溶血性和细胞保护活性。 还公开了制备化合物和组合物的方法。

公开(公告)号：US4250188A

公开(公告)日：1981-02-10

申请号：US90305

申请日：1979-11-01

Applicant: Carmelo Gandolfi ,  Carlo Passarotti ,  Alessandro Andreoni ,  Angelo Fumagalli ,  Franco Faustini ,  Roberto Ceserani ,  Maria M. Usardi

Inventor： Carmelo Gandolfi ,  Carlo Passarotti ,  Alessandro Andreoni ,  Angelo Fumagalli ,  Franco Faustini ,  Roberto Ceserani ,  Maria M. Usardi

IPC: A61K31/31 ,  A61K31/41 ,  A61P43/00 ,  C07C405/00 ,  C07D307/935 ,  C07D307/937 ,  C07D407/12 ,  A61K31/34

CPC classification number: C07D307/937 ,  C07C405/00 ,  Y10S514/822 ,  Y10S514/826 ,  Y10S514/926 ,  Y10S514/927 ,  Y10S514/929

Abstract: 2-Oxa-bicyclic prostaglandins, a method for their preparation and pharmaceutical and veterinary compositions containing them are disclosed.

Abstract translation: 公开了2-氧杂双环前列腺素，其制备方法和含有它们的药物和兽药组合物。

公开(公告)号：US4230721A

公开(公告)日：1980-10-28

申请号：US15148

申请日：1979-02-26

Applicant: Carmelo Gandolfi ,  Carlo Passarotti ,  Alessandro Andreoni ,  Angelo Fumagalli ,  Franco Faustini ,  Roberto Ceserani ,  Maria M. Usardi

Inventor： Carmelo Gandolfi ,  Carlo Passarotti ,  Alessandro Andreoni ,  Angelo Fumagalli ,  Franco Faustini ,  Roberto Ceserani ,  Maria M. Usardi

IPC: A61K31/31 ,  A61K31/41 ,  A61P43/00 ,  C07C405/00 ,  C07D307/935 ,  C07D307/937 ,  C07D407/12 ,  A61K31/557

CPC classification number: C07D307/937 ,  C07C405/00 ,  Y10S514/822 ,  Y10S514/826 ,  Y10S514/926 ,  Y10S514/927 ,  Y10S514/929

Abstract: New 2-oxa-bicyclic prostaglandin compounds, and pharmaceutical and veterinary compositions containing them, having pharmaceutical utility for example as anti-aggregating, vasodilating, and cytoprotective agents. Processes for preparing the compounds are also disclosed.

Abstract translation: 新的2-氧杂双环前列腺素化合物，以及含有它们的药物和兽药组合物，具有药物效用，例如抗聚集，血管扩张和细胞保护剂。 还公开了制备化合物的方法。

公开(公告)号：US11090285B2

公开(公告)日：2021-08-17

申请号：US16239947

申请日：2019-01-04

Applicant: Vanda Pharmaceuticals Inc.

Inventor： Marlene Michelle Dressman ,  John Joseph Feeney ,  Louis William Licamele ,  Mihael H. Polymeropoulos

IPC: A61K31/343 ,  A61K31/15 ,  G16H10/60 ,  A61K45/06 ,  A61K31/496 ,  A61K31/31 ,  A61K31/277 ,  G16H20/10

Abstract: Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.

公开(公告)号：US20210128517A1

公开(公告)日：2021-05-06

申请号：US17150428

申请日：2021-01-15

Applicant: Vanda Pharmaceuticals Inc.

Inventor： Marlene Michelle Dressman ,  John Joseph Feeney ,  Louis William Licamele ,  Mihael H. Polymeropoulos

IPC: A61K31/343 ,  A61K31/15 ,  G16H10/60 ,  A61K45/06 ,  A61K31/496 ,  A61K31/31 ,  A61K31/277 ,  G16H20/10

Abstract: Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.

公开(公告)号：US10385136B2

公开(公告)日：2019-08-20

申请号：US15465509

申请日：2017-03-21

Applicant: Vaccinex, Inc.

Inventor： Ernest S. Smith ,  Maurice Zauderer ,  William J. Bowers ,  Alan Jonason

IPC: A61K31/31 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.

公开(公告)号：US08211873B2

公开(公告)日：2012-07-03

申请号：US12851637

申请日：2010-08-06

Applicant: Shyam K Gupta ,  Linda Walker

Inventor： Shyam K Gupta ,  Linda Walker

IPC: C07C229/36 ,  C07C229/34 ,  A61K8/02 ,  A61K31/665 ,  A61K31/315 ,  A61K31/31 ,  A61K31/30 ,  A61K31/28

CPC classification number: A61K8/19 ,  A61K8/55 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7076 ,  A61K31/7135 ,  A61K31/715 ,  A61K38/063 ,  A61K45/06 ,  A61K48/00 ,  A61Q5/006 ,  A61Q19/008 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  A61K2300/00

Abstract: This invention relates to certain chirally-correct mitoprotectant phosphorylated heterocyclic agents [formula (I)], which are useful for the treatment of dermatological disorders that include challenged skin from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction; age spots; acne, loss of cellular antioxidants; skin changes associated with aging including collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles and fine lines, oxidation, damage from radiation, damage from free radicals, and damage from UV; dry skin; xerosis; ichthyosis; dandruff; brownish spots; keratoses; melasma; lentigines; liver spots; skin pigmentation including pigmented spots, dark circles under the eyes, darkened skin, and blemishes; oily skin; warts; eczema; pruritic skin; psoriasis; inflammatory dermatoses; topical inflammation; disturbed keratinization; scalp dryness; skin depigmentation, and combinations thereof;

Abstract translation: 本发明涉及某些手性正确的有丝分裂保护剂磷酸化杂环试剂[式（I）]，其可用于治疗包括来自癌症，糖尿病，放射治疗，化疗和晒伤的受侵袭皮肤的皮肤病学障碍; 线粒体功能障碍 老年斑 痤疮，细胞抗氧化剂的丧失; 与老化有关的皮肤变化，包括胶原蛋白损失，皮肤柔韧性丧失，皮肤柔软度丧失，皮肤皱纹和细纹，氧化，辐射损伤，自由基损伤和紫外线损伤; 皮肤干燥; 干燥症 鱼鳞病 头皮屑 棕色斑点 角化病 黑斑病 斑驳 肝斑; 皮肤色素沉着，包括色素斑点，眼睛下方的黑眼圈，皮肤变暗，瑕疵; 油性皮肤; 疣 湿疹; 瘙痒皮肤 银屑病; 炎性皮肤病; 局部炎症; 干扰角质化 头皮干燥; 皮肤色素沉淀及其组合;

公开(公告)号：US07964638B2

公开(公告)日：2011-06-21

申请号：US11918658

申请日：2006-04-21

Applicant: Kyoko Miura ,  Akinori Haratake

Inventor： Kyoko Miura ,  Akinori Haratake

IPC: A61K31/31 ,  C07D493/02 ,  A61P17/00

CPC classification number: A61K8/4973 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

Abstract: The present invention is to provide skin cosmetics and anti-wrinkle agents which are excellent in reducing effect on wrinkle caused by photoaging. Skin cosmetics and anti-wrinkle agents which comprise isosorbide represented by the following formula (1).

Abstract translation: 本发明提供对光老化引起的皱纹的减少效果优异的皮肤化妆品和抗皱剂。 包含由下式（1）表示的异山梨醇的皮肤化妆品和抗皱剂。