公开(公告)号：US5725887A

公开(公告)日：1998-03-10

申请号：US709452

申请日：1996-09-05

申请人： Stephen M. Martin ,  Fu-Pao Tsao

发明人： Stephen M. Martin ,  Fu-Pao Tsao

IPC分类号： A61K9/00 ,  A61L12/08 ,  A61L12/12 ,  A61K31/16

CPC分类号： A61L12/124 ,  A61K9/0048 ,  A61L12/08 ,  Y10S514/839 ,  Y10S514/912 ,  Y10S514/94

摘要： A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

公开(公告)号：US5607698A

公开(公告)日：1997-03-04

申请号：US339447

申请日：1994-11-14

申请人： Stephen M. Martin ,  Fu-Pao Tsao

发明人： Stephen M. Martin ,  Fu-Pao Tsao

IPC分类号： A61K9/00 ,  A61L12/08 ,  A61L12/12 ,  A61K33/40

CPC分类号： A61L12/124 ,  A61K9/0048 ,  A61L12/08 ,  Y10S514/839 ,  Y10S514/912 ,  Y10S514/94

摘要： A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

摘要翻译： 提供了具有活性成分的眼用溶液的防腐剂，其过氧化氢含量为约0.001％至约0.10％重量; 和二亚乙基三胺五（亚甲基膦酸）或其生理上相容的盐，以约0.002％至0.03％重量和/或0.005％至约0.20％重量的1-羟基亚乙基-1,1-二膦酸存在，或 其生理上可接受的盐。

公开(公告)号：US5576028A

公开(公告)日：1996-11-19

申请号：US414150

申请日：1995-03-29

申请人： Stephen M. Martin ,  Fu-Pao Tsao

发明人： Stephen M. Martin ,  Fu-Pao Tsao

IPC分类号： A61K9/00 ,  A61L12/08 ,  A61L12/12 ,  A61K31/16

CPC分类号： A61L12/124 ,  A61K9/0048 ,  A61L12/08 ,  Y10S514/839 ,  Y10S514/912 ,  Y10S514/94

摘要： A preservative for ophthalmic solutions having an active ingredient is provided, having a hydrogen peroxide content of about 0.001% to about 0.10% by weight; and diethylene triamine penta(methylene phosphonic acid) or a physiologically compatible salt thereof, present at about 0.002% to 0.03% by weight and/or 0.005% to about 0.20% by weight of 1-hydroxyethylidene-1,1-diphosphonic acid, or physiologically acceptable salt thereof.

摘要翻译： 提供了具有活性成分的眼用溶液的防腐剂，其过氧化氢含量为约0.001％至约0.10％重量; 和二亚乙基三胺五（亚甲基膦酸）或其生理上相容的盐，以约0.002％至0.03％重量和/或0.005％至约0.20％重量的1-羟基亚乙基-1,1-二膦酸存在，或 其生理上可接受的盐。

公开(公告)号：US1949798A

公开(公告)日：1934-03-06

申请号：US59830032

申请日：1932-03-11

申请人： EMULSOIDS INC

发明人： HUGH KNIGHT ,  SWALLEN LLOYD C ,  BANNISTER WILLIAM J

IPC分类号： A01N25/30

CPC分类号： A01N25/30 ,  Y10S514/94

公开(公告)号：US1914902A

公开(公告)日：1933-06-20

申请号：US34267129

申请日：1929-02-25

申请人： CALIFORNIA SPRAY CHEMICAL CORP

发明人： HUNTER VOLCK WILLIAM

IPC分类号： A01N25/04

CPC分类号： A01N25/04 ,  Y10S514/94

公开(公告)号：US20080075747A1

公开(公告)日：2008-03-27

申请号：US11984720

申请日：2007-11-21

申请人： Elliott Farber

发明人： Elliott Farber

IPC分类号： A61K8/06 ,  A61K8/49 ,  A61Q19/00

CPC分类号： A61Q19/00 ,  A61K8/06 ,  A61K8/062 ,  A61K8/37 ,  A61K8/463 ,  A61K8/4946 ,  A61K8/73 ,  A61K8/8147 ,  A61K8/86 ,  A61K8/927 ,  A61K8/97 ,  A61K9/0014 ,  A61K47/20 ,  A61K47/44 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/94 ,  Y10S514/941 ,  Y10S514/943

摘要： An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The pH of the composition is in a range of from about 3.0 to about 6.0; preferably, the pH of the composition is from about 5.0 to about 6.0. The composition can further comprise an acidic anionic polymer. A preferred acidic anionic polymer is a carboxypolymethylene polymer. The composition can further comprise a carbohydrate polymer such as galactoarabinan, polygalactose or polyarabinose. The composition can additionally comprise other ingredients such as herbal extracts, an antioxidant component, an emollient component, a chelator, a solvent component, or a preservative component. The composition is useful as a skin protectant.

摘要翻译： 含有尿囊素的护肤霜组合物可以包含尿囊素和至少一种基本上亲水性且可溶于水的阴离子或非离子乳化剂。 组合物的pH在约3.0至约6.0的范围内; 优选地，组合物的pH为约5.0至约6.0。 组合物还可以包含酸性阴离子聚合物。 优选的酸性阴离子聚合物是羧基聚亚甲基聚合物。 该组合物可以进一步包含碳水化合物聚合物，例如半乳糖尿蛋白，半乳糖或聚阿拉伯糖。 组合物还可以包含其它成分，例如草药提取物，抗氧化剂组分，软化剂组分，螯合剂，溶剂组分或防腐剂组分。 该组合物可用作皮肤保护剂。

公开(公告)号：US20040180853A1

公开(公告)日：2004-09-16

申请号：US10811875

申请日：2004-03-30

申请人： Alwyn Company, Inc.

发明人： Elliott Farber

IPC分类号： A61K031/715 ,  A61K031/4164

CPC分类号： A61Q19/00 ,  A61K8/06 ,  A61K8/062 ,  A61K8/37 ,  A61K8/463 ,  A61K8/4946 ,  A61K8/73 ,  A61K8/8147 ,  A61K8/86 ,  A61K8/927 ,  A61K8/97 ,  A61K9/0014 ,  A61K47/20 ,  A61K47/44 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/94 ,  Y10S514/941 ,  Y10S514/943

摘要： An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The pH of the composition is in a range of from about 3.0 to about 6.0; preferably, the pH of the composition is from about 5.0 to about 6.0. The composition can further comprise an acidic anionic polymer. A preferred acidic anionic polymer is a carboxypolymethylene polymer. The composition can further comprise a carbohydrate polymer such as galactoarabinan, polygalactose or polyarabinose. The composition can additionally comprise other ingredients such as herbal extracts, an antioxidant component, an emollient component, a chelator, a solvent component, or a preservative component. The composition is useful as a skin protectant.

摘要翻译： 含有尿囊素的护肤霜组合物可以包含尿囊素和至少一种基本上亲水性且可溶于水的阴离子或非离子乳化剂。 组合物的pH在约3.0至约6.0的范围内; 优选地，组合物的pH为约5.0至约6.0。 组合物还可以包含酸性阴离子聚合物。 优选的酸性阴离子聚合物是羧基聚亚甲基聚合物。 该组合物可以进一步包含碳水化合物聚合物，例如半乳糖尿蛋白，半乳糖或聚阿拉伯糖。 组合物还可以包含其它成分，例如草药提取物，抗氧化剂组分，软化剂组分，螯合剂，溶剂组分或防腐剂组分。 该组合物可用作皮肤保护剂。

公开(公告)号：US06531500B2

公开(公告)日：2003-03-11

申请号：US09570120

申请日：2000-05-12

申请人： Elliott Farber

发明人： Elliott Farber

IPC分类号： A61K31415

CPC分类号： A61Q19/00 ,  A61K8/06 ,  A61K8/062 ,  A61K8/37 ,  A61K8/463 ,  A61K8/4946 ,  A61K8/73 ,  A61K8/8147 ,  A61K8/86 ,  A61K8/927 ,  A61K8/97 ,  A61K9/0014 ,  A61K47/20 ,  A61K47/44 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/94 ,  Y10S514/941 ,  Y10S514/942 ,  Y10S514/943

摘要： An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone. In still another alternative, the emulsifier system can include cetyl alcohol and stearic acid. In yet another alternative, the emulsifier system can include sodium stearoyl lactylate and sodium isostearoyl lactylate. In another alternative, the emulsifier system can include at least one polyethyleneglycol ether of cetearyl alcohol. In still another alternative, the emulsifier system can include a polyethylene glycol ester of stearic acid and glyceryl stearate. The composition can include other ingredients. Among the diseases that can be treated is epidermolysis bullosa.

公开(公告)号：US06458383B2

公开(公告)日：2002-10-01

申请号：US09751968

申请日：2000-12-29

申请人： Feng-Jing Chen ,  Mahesh V. Patel ,  David T. Fikstad

发明人： Feng-Jing Chen ,  Mahesh V. Patel ,  David T. Fikstad

IPC分类号： A61K948

CPC分类号： A61K9/5073 ,  A61K9/1075 ,  A61K9/4858 ,  A61K9/4891 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/94 ,  Y10S514/941 ,  Y10S514/942 ,  Y10S514/943 ,  Y10S514/975

摘要： A delayed release pharmaceutical dosage form for oral administration of a hydrophilic drug, e.g., a polysaccharide drug such as low molecular weight heparin, are provided. The dosage form comprises a composition of: (a) a therapeutically effective amount of low molecular weight heparin; (b) a bile salt or bile acid; (c) at least one surfactant selected from hydrophilic surfactants, lipophilic surfactants, and mixtures thereof; and a means for delaying release of the composition from the dosage form following oral administration. Osmotic drug delivery systems for oral administration of a hydrophilic drug are also provided, wherein an osmotically activated device houses the drug, a bile salt or bile acid, and at least one surfactant selected from the group consisting of hydrophilic surfactants, lipophilic surfactants, and mixtures thereof. Methods for administering hydrophilic drugs, particularly polysaccharide drugs such as low molecular weight heparin, are also provided.

摘要翻译： 提供用于口服给予亲水药物的延迟释放药物剂型，例如多糖药物如低分子量肝素。 剂型包含以下组合物：（a）治疗有效量的低分子量肝素; （b）胆汁盐或胆汁酸; （c）至少一种选自亲水性表面活性剂，亲脂性表面活性剂及其混合物的表面活性剂; 以及在口服给药后延迟组合物从剂型释放的手段。 还提供了用于口服给药亲水药物的渗透药物递送系统，其中渗透活化的装置容纳药物，胆汁盐或胆汁酸，以及选自亲水性表面活性剂，亲脂性表面活性剂和混合物中的至少一种表面活性剂 其中。 还提供了用于给予亲水药物，特别是多糖药物如低分子量肝素的方法。

公开(公告)号：US20020102288A1

公开(公告)日：2002-08-01

申请号：US09939816

申请日：2001-08-27

发明人： Elliott Farber

IPC分类号： A61M035/00 ,  A61K009/70

CPC分类号： A61K8/062 ,  A61K8/0208 ,  A61K8/06 ,  A61K8/37 ,  A61K8/463 ,  A61K8/4946 ,  A61K8/73 ,  A61K8/8147 ,  A61K8/86 ,  A61K8/927 ,  A61K8/97 ,  A61K9/0014 ,  A61K47/20 ,  A61K2800/52 ,  A61Q19/00 ,  Y10S514/939 ,  Y10S514/94 ,  Y10S514/941 ,  Y10S514/943

摘要： A flexible applicator for applying an oil-in-water emulsion comprises: (1) an allantoin-containing oil-in-water emulsion; and (2) a flexible element that adsorbs or absorbs the emulsion such that the emulsion is applied to the skin of a patient on whom the flexible applicator is placed. The allantoin-containing emulsion, containing allantoin and an emulsifier, has improved stability coming from the adjustment of the pH to a range of 3.0 to 6.0; preferably, the pH is in the range of 4.5 to about 5.8. The lower pH preserves the stability of the allantoin and the functionality of the emulsifier system is maintained. The emulsifier system can be a nonionic emulsifier or an anionic emulsifier plus beeswax. The acid used to adjust the pH can be an organic acid or an inorganic acid. The emulsion can further comprise other ingredients such as herbal extracts, chelating agents, preservatives, emollients, solvents, and fragrance. The flexible element can be in the form of a bandage or wipe, and can be formed of a material such as cotton, cellulose, nylon, rayon, a non-woven fabric, or a plastic polymer.

摘要翻译： 一种用于施用水包油乳液的柔性施用器包括：（1）含尿囊素的水包油乳液; 和（2）吸附或吸收乳液的柔性元件，使得乳液被施加到放置柔性涂抹器的患者的皮肤上。 含有尿囊素和乳化剂的含有尿囊素的乳液具有改善的稳定性，从pH调节至3.0-6.0的范围; 优选地，pH在4.5至约5.8的范围内。 较低的pH保持了尿囊素的稳定性，并保持了乳化剂体系的功能。 乳化剂系统可以是非离子乳化剂或阴离子乳化剂加蜂蜡。 用于调节pH的酸可以是有机酸或无机酸。 乳液可以进一步包含其它成分，例如草药提取物，螯合剂，防腐剂，润肤剂，溶剂和香料。 柔性元件可以是绷带或擦拭物的形式，并且可以由诸如棉，纤维素，尼龙，人造丝，无纺织物或塑料聚合物的材料形成。