公开(公告)号：US20070129293A1

公开(公告)日：2007-06-07

申请号：US10573905

申请日：2004-09-29

Applicant: Thomas Coleman ,  Osman Yilmaz

Inventor： Thomas Coleman ,  Osman Yilmaz

IPC: A61K38/18

CPC classification number: A61K38/1816 ,  A61K38/191 ,  A61K38/20 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/426

Abstract: A method of treating, preventing, delaying the onset, and/or reducing the effects of proinflammatory cytokines in conditions including, but not limited to, sepsis, adhesion formation, wounds, organ failure, chronic disease, general inflammatory conditions resulting from infection, scarring resulting from injury and incisions, and combinations thereof.

Abstract translation: 在包括但不限于脓毒症，粘连形成，伤口，器官功能衰竭，慢性疾病，由感染引起的一般炎性病症，瘢痕形成的病症中治疗，预防，延缓发作和/或减少促炎细胞因子的作用的方法 由损伤和切口引起的，以及它们的组合。

公开(公告)号：US20070124995A1

公开(公告)日：2007-06-07

申请号：US10595735

申请日：2004-12-09

Applicant: Bruce Kania ,  Frank Stewart ,  Russell Smith ,  Thomas Coleman ,  Alfred Cunningham

Inventor： Bruce Kania ,  Frank Stewart ,  Russell Smith ,  Thomas Coleman ,  Alfred Cunningham

IPC: A01G31/00 ,  A01K61/00

CPC classification number: A01K67/033 ,  A01G9/00 ,  A01K31/14 ,  A01K61/60 ,  A01K61/70 ,  Y02A40/826 ,  Y02A40/83 ,  Y02P60/642

Abstract: A floating habitat designed to be renewably buoyant, self-sustaining and optionally specialized for waterfowl nesting. The first embodiment comprises one or more flotation units, a source of compressed air, and a means for connecting the source of compressed air to the flotation units. Each flotation unit comprises an individual supply hose, an inflatable bladder, a relief valve, a diffusing manifold, bottom mesh, top mesh, and buoyant growth medium. An alternative embodiment comprises a self-compensating buoyancy system. In the waterfowl nesting embodiment, the floating habitat includes one or more waterfowl nesting structures and construction material selected to optimize the nesting habitat. The floating habitat can be comprised of scrap pieces or layers of polyester mesh material. The floating habitats can be combined to provide safe habitat for juvenile waterfowl, encourage colony nesting, or allow a variety of waterfowl or shore bird species to enjoy suitable habitat on the same floating habitat.

Abstract translation: 一个漂浮的栖息地，设计为可再生浮力，自我维持，并可选择专门为水禽筑巢。 第一实施例包括一个或多个浮选单元，压缩空气源和用于将压缩空气源连接到浮选单元的装置。 每个浮选单元包括单独的供应软管，可充气囊，安全阀，扩散歧管，底部网，顶部网和浮力生长介质。 替代实施例包括自补偿浮力系统。 在水禽嵌套实施例中，浮动栖息地包括一个或多个水禽嵌套结构和被选择用于优化嵌套栖息地的建筑材料。 浮动栖息地可以由废料片或聚酯网材料层组成。 浮游栖息地可以组合起来，为少年水鸟提供安全栖息地，鼓励殖民地筑巢，或允许各种水鸟或岸鸟类物种在相同的浮动栖息地享受合适的栖息地。

公开(公告)号：US20060130763A1

公开(公告)日：2006-06-22

申请号：US11272909

申请日：2005-11-14

Applicant: David Emerson ,  Robert Garner ,  Michael Bergmann ,  Keenan Brown ,  Michael Pennington ,  Thomas Coleman

Inventor： David Emerson ,  Robert Garner ,  Michael Bergmann ,  Keenan Brown ,  Michael Pennington ,  Thomas Coleman

IPC: C23C16/00

CPC classification number: C23C16/46 ,  C30B25/105 ,  H01L21/67103

Abstract: A vapor deposition reactor and associated method are disclosed that increase the lifetime and productivity of a filament-based resistive-heated vapor deposition system. The reactor and method provide for heating the filament while permitting the filament to move as it expands under the effect of increasing temperature while limiting the expanding movement of the filament to an amount that prevents the expanding movement of the filament from creating undesired contact with any portions of the reactor.

Abstract translation: 公开了一种提高长丝基电阻加热气相沉积系统的寿​​命和生产率的气相沉积反应器和相关方法。 反应器和方法提供加热细丝，同时允许细丝在温度升高的作用下膨胀时移动，同时将长丝的膨胀运动限制到防止细丝的膨胀运动与任何部分产生不期望的接触的量 的反应器。

公开(公告)号：US20050041600A1

公开(公告)日：2005-02-24

申请号：US10653632

申请日：2003-09-02

Applicant: Gregory Moffatt ,  Joanne Wakefield ,  Thomas Coleman ,  Mark Riley ,  Charles Hubbard

Inventor： Gregory Moffatt ,  Joanne Wakefield ,  Thomas Coleman ,  Mark Riley ,  Charles Hubbard

IPC: H04J14/02 ,  H04L12/28

CPC classification number: H04J14/0227 ,  H04J14/0221 ,  H04J14/0246 ,  H04J14/025 ,  H04J14/0283

Abstract: A computerized method for modifying an optical wavelength division multiplexing (WDM) network is described. The method includes providing an initial configuration of the optical WDM network. At least one parameter that represents a characteristic of a span in the optical WDM network as defined by the initial configuration is evaluated. The initial configuration of the optical WDM network is modified in response to the evaluation. The method can also include determining if a predetermined set of engineering rules are satisfied.

Abstract translation: 描述了用于修改光波分复用（WDM）网络的计算机化方法。 该方法包括提供光学WDM网络的初始配置。 评估表示由初始配置定义的光WDM网络中的跨度的特性的至少一个参数。 响应于评估，光学WDM网络的初始配置被修改。 该方法还可以包括确定是否满足预定的一组工程规则。

公开(公告)号：US10162818B2

公开(公告)日：2018-12-25

申请号：US15587121

申请日：2017-05-04

Applicant: Michael Callahan ,  Thomas Coleman

Inventor： Michael Callahan ,  Thomas Coleman

IPC: G10L13/02 ,  G06F17/28 ,  G10L15/24 ,  G10L25/48 ,  G10L13/00 ,  G10L13/04 ,  A61B5/0488

Abstract: A method and apparatus are provided for processing a set of communicated signals associated with a set of muscles, such as the muscles near the larynx of the person, or any other muscles the person use to achieve a desired response. The method includes the steps of attaching a single integrated sensor, for example, near the throat of the person proximate to the larynx and detecting an electrical signal through the sensor. The method further includes the steps of extracting features from the detected electrical signal and continuously transforming them into speech sounds without the need for further modulation. The method also includes comparing the extracted features to a set of prototype features and selecting a prototype feature of the set of prototype features providing a smallest relative difference.

公开(公告)号：US08949129B2

公开(公告)日：2015-02-03

申请号：US13964715

申请日：2013-08-12

Applicant: Michael Callahan ,  Thomas Coleman

Inventor： Michael Callahan ,  Thomas Coleman

IPC: G10L13/02 ,  G10L25/48 ,  G10L13/04 ,  G10L15/24 ,  A61B5/0488

CPC classification number: G06F17/28 ,  A61B5/04886 ,  G10L13/00 ,  G10L13/043 ,  G10L15/24 ,  G10L25/48

Abstract: A method and apparatus are provided for processing a set of communicated signals associated with a set of muscles, such as the muscles near the larynx of the person, or any other muscles the person use to achieve a desired response. The method includes the steps of attaching a single integrated sensor, for example, near the throat of the person proximate to the larynx and detecting an electrical signal through the sensor. The method further includes the steps of extracting features from the detected electrical signal and continuously transforming them into speech sounds without the need for further modulation. The method also includes comparing the extracted features to a set of prototype features and selecting a prototype feature of the set of prototype features providing a smallest relative difference.

Abstract translation: 提供了一种方法和装置，用于处理与一组肌肉相关联的一组传播信号，例如人的喉部附近的肌肉，或者人们用于实现期望的反应的任何其他肌肉。 该方法包括以下步骤：附接单个集成传感器，例如靠近喉部的人的喉部，并通过传感器检测电信号。 该方法还包括以下步骤：从检测到的电信号中提取特征，并将其连续地变换成语音，而不需要进一步调制。 该方法还包括将所提取的特征与一组原型特征进行比较，并且选择提供最小相对差异的原始特征集的原型特征。

公开(公告)号：US08673861B2

公开(公告)日：2014-03-18

申请号：US13448345

申请日：2012-04-16

Applicant: Anthony Cerami ,  Michael Brines ,  Thomas Coleman

Inventor： Anthony Cerami ,  Michael Brines ,  Thomas Coleman

IPC: A61K38/10 ,  A61P11/00 ,  A61K35/37 ,  A61K35/34 ,  A61K35/42

CPC classification number: C07K14/505 ,  A61K38/00 ,  C07K14/435 ,  C07K14/575 ,  C07K14/71 ,  C07K2319/00

Abstract: Provided herein are tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are generally located on or within the region of the cytokine receptor ligand that faces away from a receptor complex while the ligand is bound to the receptor. Also provide herein are fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO; methods for treating or preventing a disease or disorder using tissue protective peptides; and methods for enhancing excitable tissue function using tissue protective peptides.

公开(公告)号：US20120264682A1

公开(公告)日：2012-10-18

申请号：US13448345

申请日：2012-04-16

Applicant: Anthony CERAMI ,  Michael Brines ,  Thomas Coleman

Inventor： Anthony CERAMI ,  Michael Brines ,  Thomas Coleman

IPC: A61K38/08 ,  C12N5/02 ,  A61P17/00 ,  A61P19/08 ,  A61P3/10 ,  A61K38/17 ,  A61P13/12 ,  A61K38/10 ,  A61P29/00 ,  A01N1/02 ,  A61P25/00

CPC classification number: C07K14/505 ,  A61K38/00 ,  C07K14/435 ,  C07K14/575 ,  C07K14/71 ,  C07K2319/00

Abstract: Provided herein are tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are generally located on or within the region of the cytokine receptor ligand that faces away from a receptor complex while the ligand is bound to the receptor. Also provide herein are fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO; methods for treating or preventing a disease or disorder using tissue protective peptides; and methods for enhancing excitable tissue function using tissue protective peptides.

公开(公告)号：US08268629B2

公开(公告)日：2012-09-18

申请号：US11156714

申请日：2005-06-21

Applicant: Thomas Coleman ,  Frederick Wolf ,  James E Bruya

Inventor： Thomas Coleman ,  Frederick Wolf ,  James E Bruya

IPC: G01N33/00

CPC classification number: G01N33/2852 ,  G01N27/048 ,  G01N27/06 ,  G01N27/221 ,  G01N27/223 ,  G01N33/2847 ,  Y10T436/21 ,  Y10T436/218

Abstract: A system and method for characterizing a liquid hydrocarbon fuel having unknown or variable composition is described and shown herein.

Abstract translation: 本文描述和示出了用于表征具有未知或可变组成的液体烃燃料的系统和方法。

公开(公告)号：US20090221482A1

公开(公告)日：2009-09-03

申请号：US11997898

申请日：2006-08-07

Applicant: Anthony Cerami ,  Michael Brines ,  Thomas Coleman

Inventor： Anthony Cerami ,  Michael Brines ,  Thomas Coleman

IPC: A61K38/17 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  A61K38/10 ,  A61K38/08 ,  A61K38/07 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12N5/08 ,  C12P21/02

CPC classification number: C07K14/505 ,  A61K38/00 ,  C07K14/435 ,  C07K14/575 ,  C07K14/71 ,  C07K2319/00

Abstract: The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor complex. In particular, the present invention is drawn to tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including Erythropoietin (EPO), that are not involved in the binding of the ligand to the receptor complex, e.g., to the EPO receptor homodimer. Accordingly, the tissue protective peptides of the invention are derived from the amino acid sequences of regions of cytokine receptor ligands that are generally located on or within the region of the ligand protein that is opposite of the receptor complex, i.e., are generally derived from amino acid sequences of regions of the ligand protein that face away from the receptor complex while the ligand is bound to the receptor. The invention is further directed to the consensus sequences for use in engineering a synthetic tissue protective peptide. These tissue protective peptides also include fragments, chimeras, as well as peptides designed to mimic the spatial localization of key amino acid residues within the tissue protective receptor ligands, e.g., EPO. The invention further encompasses methods for treating or preventing a disease or disorder using tissue protective peptides of the current invention. The invention also encompasses methods for enhancing excitable tissue function using tissue protective peptides of the current invention.

Abstract translation: 本发明涉及新型组织保护肽。 本发明的组织保护肽可以结合组织保护性受体复合物。 特别地，本发明涉及来源于或共享共有序列的组织保护肽，其中部分细胞因子受体配体包括促红细胞生成素（EPO），其不参与配体与受体复合物的结合，例如与 EPO受体同二聚体。 因此，本发明的组织保护肽衍生自通常位于与受体复合体相反的配体蛋白的区域上或内部的细胞因子受体配体的区域的氨基酸序列，即通常衍生自氨基 当配体与受体结合时，配体蛋白的表面远离受体复合物的酸序列。 本发明还涉及用于工程化合成组织保护肽的共有序列。 这些组织保护肽还包括片段，嵌合体以及旨在模拟组织保护性受体配体例如EPO内的关键氨基酸残基的空间定位的肽。 本发明还包括使用本发明的组织保护肽治疗或预防疾病或病症的方法。 本发明还包括使用本发明的组织保护肽增强可兴奋组织功能的方法。