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公开(公告)号:US20080181913A1
公开(公告)日:2008-07-31
申请号:US12010654
申请日:2008-01-28
申请人: Raymond Allen Dwek , Christopher Scanlan , David Cameron Dunlop , Fatma MH Mansab , Sarah Erin Tully , Paul Wentworth , Nicole Zitzmann
发明人: Raymond Allen Dwek , Christopher Scanlan , David Cameron Dunlop , Fatma MH Mansab , Sarah Erin Tully , Paul Wentworth , Nicole Zitzmann
CPC分类号: A61K39/21 , A61K39/12 , A61K39/385 , A61K2039/6087 , A61K2039/645 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要: Disclosed are compositions and methods useful for inducing an immunogenic response in a subject or host. In particular, the compositions and methods may be directed to carbohydrate HIV vaccines and to methods of producing a carbohydrate HIV vaccine by introducing antigenic sugars into mimics of the glycans of the HIV envelope glycoproteins gp120 and gp41.
摘要翻译: 公开了用于在受试者或宿主中诱导免疫原性应答的组合物和方法。 特别地,组合物和方法可以针对碳水化合物HIV疫苗以及通过将抗原性糖引入HIV包膜糖蛋白gp120和gp41的聚糖的模拟物来生产碳水化合物HIV疫苗的方法。
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公开(公告)号:US06465487B1
公开(公告)日:2002-10-15
申请号:US09209033
申请日:1998-12-10
申请人: Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
发明人: Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
IPC分类号: A61K31445
CPC分类号: A61K31/00 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要: Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods for treating lipid storage diseases using compounds that inhibit glucosyl transferance enzymes.
摘要翻译: 抑制宿主细胞膜出芽病毒的形态发生和由此引起的感染的方法使用抑制宿主细胞葡糖苷酶或葡糖基转移酶的化合物的方法。 使用抑制葡糖基转移酶的化合物治疗脂质储存疾病的方法。
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