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    Device for isolating regions of living tissue
    31.
    发明授权
    Device for isolating regions of living tissue 失效
    用于隔离活组织区域的装置

    公开(公告)号：US06631282B2

    公开(公告)日：2003-10-07

    申请号：US09970021

    申请日：2001-10-02

    Applicant: Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian Cortella ,  Mark D. Agostino

    Inventor： Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian Cortella ,  Mark D. Agostino

    IPC: A61B500

    CPC classification number: A61B5/6841 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/1455

    Abstract: A device and method are provided for use with a non-invasive optical measurement system, such as a thermal gradient spectrometer for improved determination of analyte concentrations within living tissue. In a preferred embodiment, a site selector is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.

    Abstract translation: 提供了一种用于非侵入式光学测量系统的装置和方法，所述非侵入性光学测量系统例如用于改善生物体内分析物浓度测定的热梯度光谱仪。 在优选实施例中，站点选择器被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。 站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。 当光谱仪必须临时从病人的皮肤上移除时，例如允许患者移动，将场地选择器固定在前臂上，以保持皮肤上一致的测量部位。 当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

    SYSTEMS AND METHODS FOR DETERMINING PHYSIOLOGICAL PARAMETERS USING MEASURED ANALYTE VALUES
    32.
    发明申请
    SYSTEMS AND METHODS FOR DETERMINING PHYSIOLOGICAL PARAMETERS USING MEASURED ANALYTE VALUES 审中-公开
    使用测量分析值确定生理参数的系统和方法

    公开(公告)号：US20130123592A1

    公开(公告)日：2013-05-16

    申请号：US13609098

    申请日：2012-09-10

    Applicant: Peter Rule

    Inventor： Peter Rule

    IPC: A61B5/15 ,  A61B5/1455

    CPC classification number: A61B5/150992 ,  A61B5/029 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150862 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61M2005/1404 ,  G01N21/359

    Abstract: Systems and methods for determining a physiological parameter in a patient are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a fluid sample received from a patient, a medical sensor configured to measure second analyte data in the patient, and a processor configured to receive the first analyte data and the second analyte data and to determine a physiological parameter based at least in part on the first analyte data and the second analyte data. In certain such embodiments, the medical sensor may be a pulse oximeter, and the physiological parameter may include a cardiovascular parameter including, for example, cardiac output.

    Abstract translation: 提供了用于确定患者生理参数的系统和方法。 在某些实施例中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品中的第一分析物数据，被配置为测量患者中的第二分析物数据的医学传感器，以及被配置为接收第一分析物数据 和第二分析物数据，并且至少部分地基于第一分析物数据和第二分析物数据来确定生理参数。 在某些这样的实施例中，医疗传感器可以是脉搏血氧计，并且生理参数可以包括包括例如心输出量的心血管参数。

    APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES
    40.
    发明申请
    APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开

    公开(公告)号：US20100030137A1

    公开(公告)日：2010-02-04

    申请号：US12511014

    申请日：2009-07-28

    Applicant: W. Dale Hall ,  David N. Callicoat ,  Jennifer H. Gable ,  James R. Braig ,  Kenneth G. Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    Inventor： W. Dale Hall ,  David N. Callicoat ,  Jennifer H. Gable ,  James R. Braig ,  Kenneth G. Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC: A61M5/168

    CPC classification number: A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    Abstract: An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

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