INSULINOTROPIC PEPTIDE SYNTHESIS USING SOLID AND SOLUTION PHASE COMBINATION TECHNIQUES
    31.
    发明申请
    INSULINOTROPIC PEPTIDE SYNTHESIS USING SOLID AND SOLUTION PHASE COMBINATION TECHNIQUES 审中-公开
    使用固相和溶液相组合技术的胰岛素肽合成

    公开(公告)号:US20110213082A1

    公开(公告)日:2011-09-01

    申请号:US13105435

    申请日:2011-05-11

    IPC分类号: C08G61/00 C07K7/08

    CPC分类号: C07K14/605 A61K38/00

    摘要: The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solid solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts.

    摘要翻译: 本发明涉及使用固相和溶液相(“混合”)方法合成的促胰岛素肽的制备。 通常,该方法包括使用固相化学合成三种不同的肽中间体片段。 然后使用溶液相化学为其中一个片段添加另外的氨基酸材料。 然后将片段在固溶相中偶联在一起。 在其中一个片段中使用假脯氨酸使得该片段的固相合成减轻了该片段随后与其它片段的溶液相偶联。 本发明对于形成促胰岛素肽如GLP-1(7-36)及其天然和非天然对应物非常有用。

    Low bias current amplifier
    32.
    发明授权
    Low bias current amplifier 有权
    低偏置电流放大器

    公开(公告)号:US07948316B2

    公开(公告)日:2011-05-24

    申请号:US12473978

    申请日:2009-05-28

    IPC分类号: H03F3/26

    摘要: An amplifier is provided that includes an output portion that sources and sinks current associated with an output load and an amplification portion that is biased by a relatively small bias current with respect to an output current of the amplifier. The amplification portion provides an amplified output signal to the output portion. The amplifier further comprises at least one impedance component coupled between the output portion and the amplification portion to alter at least one pole associated with the amplifier to mitigate instability of the amplifier related to the relatively small bias current.

    摘要翻译: 提供了一种放大器,其包括输出部分,其输出和吸收与输出负载相关联的电流以及相对于放大器的输出电流被相对小的偏置电流偏置的放大部分。 放大部分向输出部分提供放大的输出信号。 放大器还包括耦合在输出部分和放大部分之间的至少一个阻抗分量,以改变与放大器相关联的至少一个极点,以减轻与相对小的偏置电流相关的放大器的不稳定性。

    WIRELESS COMMUNICATION METHOD, BASE STATION, INDOOR COMMUNICATION SYSTEM AND HANDOVER METHOD
    33.
    发明申请
    WIRELESS COMMUNICATION METHOD, BASE STATION, INDOOR COMMUNICATION SYSTEM AND HANDOVER METHOD 审中-公开
    无线通信方法,基站,室内通信系统和切换方法

    公开(公告)号:US20110009149A1

    公开(公告)日:2011-01-13

    申请号:US12882675

    申请日:2010-09-15

    申请人: Lin Chen Ailin Deng

    发明人: Lin Chen Ailin Deng

    IPC分类号: H04B7/00 H04W36/00

    CPC分类号: H04W36/0072

    摘要: A wireless communication method, a Base Station (BS), an indoor communication system, and a handover method are disclosed. In this method, the working frequency of the service carrier of the indoor coverage system is preset to be different from the working frequency of the service carrier of the outdoor macro cell system, the working frequency of the beacon carrier of the indoor coverage system is preset to be the same as the working frequency of the service carrier of the outdoor macro cell system, and a common channel is allocated on the beacon carrier of the indoor coverage system. With the present invention, the MS can reside in and hand over to the expected wireless communication system smoothly, the intra-frequency interference and pilot pollution between the neighboring wireless communication systems are overcome, and the communication quality of the wireless communication system is improved.

    摘要翻译: 公开了无线通信方法,基站(BS),室内通信系统和切换方法。 在该方法中,室内覆盖系统的业务载波的工作频率预先设定为与室外宏小区系统的业务载波的工作频率不同,室内覆盖系统的信标载波的工作频率为预设 与室外宏小区系统的服务载波的工作频率相同,并且在室内覆盖系统的信标载波上分配公共信道。 利用本发明,MS可以平稳地驻留在预期的无线通信系统中,克服了相邻无线通信系统之间的频率间干扰和导频污染,提高了无线通信系统的通信质量。

    METHOD AND SYSTEM FOR REAL TIME PRODUCTION MANAGEMENT AND RESERVOIR CHARACTERIZATION
    34.
    发明申请
    METHOD AND SYSTEM FOR REAL TIME PRODUCTION MANAGEMENT AND RESERVOIR CHARACTERIZATION 有权
    用于实时生产管理和储层特征的方法和系统

    公开(公告)号:US20100145667A1

    公开(公告)日:2010-06-10

    申请号:US12330673

    申请日:2008-12-09

    IPC分类号: G06F19/00 G06G7/48

    CPC分类号: E21B43/00 E21B49/00

    摘要: The present invention is a system and method for generating predictions for various parameters in a reservoir. The invention includes receiving input data characterizing the reservoir and determining transient areas. The transient areas are determined by receiving data from the reservoir, transforming the data using discrete wavelet transformation to produce transformed data, removing outliers from the transformed data, identifying and reducing noise from in the transformed data and then detecting transient areas in the transformed data. A computer model is produced in response to the transient data and predictions for parameters in the reservoir are determined. These predictions are verified by comparing predictive values with a reservoir model and then the predictions for the various parameters can be used.

    摘要翻译: 本发明是用于产生储存器中各种参数的预测的系统和方法。 本发明包括接收表征储层的输入数据并确定瞬时区域。 通过从储层接收数据来确定瞬态区域,使用离散小波变换来变换数据以产生变换数据,从经变换的数据中去除异常值,识别和减少经变换的数据中的噪声,然后检测变换数据中的瞬态区域。 响应于瞬态数据产生计算机模型,并确定储层中参数的预测。 这些预测通过将预测值与储层模型进行比较来验证,然后可以使用各种参数的预测。

    DATA ACCESS TOOL FOR PROGRAMMABLE GRAPHICS HARDWARE
    35.
    发明申请
    DATA ACCESS TOOL FOR PROGRAMMABLE GRAPHICS HARDWARE 有权
    数据访问工具可编程图形硬件

    公开(公告)号:US20090027407A1

    公开(公告)日:2009-01-29

    申请号:US11782509

    申请日:2007-07-24

    IPC分类号: G06T1/00

    CPC分类号: G06T15/005

    摘要: Methods and apparatuses for accessing data within programmable graphics hardware are provided. According to one aspect, a user inserts special log commands into a software program, which is compiled into instructions for the programmable graphics hardware to execute. The hardware writes data to an external memory during runtime according to a flow control protocol, and the software driver reads the data from the memory to display to the user.

    摘要翻译: 提供了在可编程图形硬件内访问数据的方法和装置。 根据一个方面,用户将特殊的日志命令插入到可编程图形硬件执行的指令中的软件程序中。 根据流控制协议,硬件在运行时将数据写入外部存储器,软件驱动程序从存储器读取数据以显示给用户。

    METHOD AND DEVICE FOR PERFORMING USER-DEFINED CLIPPING IN OBJECT SPACE
    36.
    发明申请
    METHOD AND DEVICE FOR PERFORMING USER-DEFINED CLIPPING IN OBJECT SPACE 有权
    用于在对象空间中执行用户定义的剪辑的方法和设备

    公开(公告)号:US20080062197A1

    公开(公告)日:2008-03-13

    申请号:US11531205

    申请日:2006-09-12

    申请人: Ning Bi Lin Chen

    发明人: Ning Bi Lin Chen

    IPC分类号: G09G5/00

    CPC分类号: G06T15/30

    摘要: A method and device for performing and processing user-defined clipping in object space to reduce the number of computations needed for the clipping operation. The method and device also combine the modelview transformation of the vertex coordinates with projection transform. The user-defined clipping in object space provides a higher performance and less power consumption by avoiding generation of eye coordinates if there is no lighting. The device includes a driver for the user-defined clipping in the object space to perform dual mode user-defined clipping in object space when a lighting function is disabled and in eye space when the lighting function is enabled.

    摘要翻译: 一种用于在对象空间中执行和处理用户定义的限幅以减少剪切操作所需的计算次数的方法和装置。 该方法和装置还将顶点坐标的modelview变换与投影变换相结合。 对象空间中的用户定义的剪辑通过避免在没有照明的情况下产生眼睛坐标来提供更高的性能和更低的功耗。 该设备包括用于在对象空间中的用户定义的剪切的驱动器,以在禁用照明功能时在对象空间中执行双模式用户定义的剪辑,并且在启用照明功能时在眼睛空间中执行双模式用户定义的剪辑。

    Insulinotropic peptide synthesis using solid and solution phase combination techniques
    37.
    发明申请
    Insulinotropic peptide synthesis using solid and solution phase combination techniques 审中-公开
    使用固相和溶液相组合技术的胰岛素肽合成

    公开(公告)号:US20080004429A1

    公开(公告)日:2008-01-03

    申请号:US11821017

    申请日:2007-06-21

    IPC分类号: C07K1/10 C07K1/00 C07K5/00

    CPC分类号: C07K14/605 A61K38/00

    摘要: The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solid solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as GLP-1(7-36) and its natural and non-natural counterparts.

    摘要翻译: 本发明涉及使用固相和溶液相(“混合”)方法合成的促胰岛素肽的制备。 通常,该方法包括使用固相化学合成三种不同的肽中间体片段。 然后使用溶液相化学为其中一个片段添加另外的氨基酸材料。 然后将片段在固溶相中偶联在一起。 在其中一个片段中使用假脯氨酸使得该片段的固相合成减轻了该片段随后与其它片段的溶液相偶联。 本发明对于形成促胰岛素肽如GLP-1(7-36)及其天然和非天然对应物非常有用。

    Dynamic impedance compensation circuit and method
    39.
    发明申请
    Dynamic impedance compensation circuit and method 有权
    动态阻抗补偿电路及方法

    公开(公告)号:US20060097749A1

    公开(公告)日:2006-05-11

    申请号:US10982485

    申请日:2004-11-05

    IPC分类号: H03K17/16

    CPC分类号: H03K19/0005

    摘要: An impedance compensation circuit generates per-group pull-up impedance information and per-group pull-down impedance information to calibrate a plurality of input/output pads and dynamically updates impedance information on a per channel basis. A group refers to a group of I/O pads having similar output drive strengths in a channel. A channel refers to all I/O pads, which collectively provide a bus interface to an external device. For example, all the I/O pads interfacing with a memory module may be grouped into a channel, and address I/O pads in a channel may be arranged into a “group.” Memory I/O pads may be grouped together into a channel since memory interface pads have input/output characteristics that may be different from those of other types of I/O pads in the chip. According to one embodiment, per-group programmable offset information provides calibration information that may be different for each group in each channel.

    摘要翻译: 阻抗补偿电路产生每组上拉阻抗信息和每组下拉阻抗信息以校准多个输入/输出焊盘,并基于每个通道动态地更新阻抗信息。 组是指在通道中具有相似输出驱动强度的一组I / O焊盘。 一个通道是指所有的I / O焊盘,它们共同地为外部设备提供总线接口。 例如,与存储器模块接口的所有I / O焊盘可以分组成通道,并且通道中的地址I / O焊盘可以被布置成“组”。 存储器I / O焊盘可以被组合在一起成为通道,因为存储器接口焊盘具有与芯片中的其它类型的I / O焊盘的输入/输出特性不同的输入/输出特性。 根据一个实施例,每组可编程偏移信息提供对于每个通道中的每个组可以不同的校准信息。

    Non-stalled requesting texture cache
    40.
    发明授权
    Non-stalled requesting texture cache 失效
    非缓存请求纹理缓存

    公开(公告)号:US6011565A

    公开(公告)日:2000-01-04

    申请号:US057628

    申请日:1998-04-09

    IPC分类号: G06T15/00 G06F12/08 G09G5/00

    CPC分类号: G06F12/0875 G06F12/0864

    摘要: A caching system for increasing the operation concurrency between a cache module and a memory module by comparing received memory block identifiers, which correspond to texels needed for pixel composition, with memory block identifiers corresponding to texels locally stored within the cache module. If the received memory block identifiers match the memory block identifiers corresponding to locally cached texels, the system transmits these texels to a texture filter unit for pixel composition. If the received memory block identifiers do not match memory block identifiers corresponding to the locally cached texels, the system retrieves these texels from the memory module as fast as possible and then updates the cache module with the new texels. A plurality of first in, first out buffers are used to assist a controller module with synchronizing the transmission of the texels from the cache module and the overwriting of the texels received from the memory module into the cache module. Once locally cached, these texels also are transmitted to the texture filter unit for pixel composition.

    摘要翻译: 一种缓存系统,用于通过将对应于像素合成所需的纹理元素的接收到的存储器块标识符与对应于本地存储在高速缓存模块中的纹素的存储器块标识符相比较来增加高速缓存模块和存储器模块之间的操作并发性。 如果接收到的存储块标识符与对应于本地缓存的纹素的存储器块标识符相匹配,则系统将这些纹素传送到用于像素组合的纹理滤波器单元。 如果接收到的存储器块标识符与对应于本地缓存的纹素的存储器块标识符不匹配,则系统尽可能快地从存储器模块中检索这些纹素,然后用新的纹素更新缓存模块。 多个先进先出缓冲器用于辅助控制器模块,使来自高速缓存模块的纹素的传输同步,以及将从存储器模块接收的纹素的覆盖写入缓存模块。 一旦本地缓存,这些纹素也被传送到纹理滤波器单元以进行像素组合。