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74 条记录 (耗时 0.048 秒)

    Method for identifying compounds for inhibition of cancerous lesions
    31.
    发明授权
    Method for identifying compounds for inhibition of cancerous lesions 失效
    识别用于抑制癌性病变的化合物的方法

    公开(公告)号：US5858694A

    公开(公告)日：1999-01-12

    申请号：US866027

    申请日：1997-05-30

    申请人： Gary A. Piazza ,  Rifat Pamukcu ,  W. Joseph Thompson

    发明人： Gary A. Piazza ,  Rifat Pamukcu ,  W. Joseph Thompson

    IPC分类号： C12Q1/26 ,  C12Q1/44 ,  C12Q1/533 ,  G01N33/50

    CPC分类号： C12Q1/44 ,  C12Q1/26 ,  C12Q1/533 ,  G01N33/5011

    摘要： This invention provides a method to identify compounds potentially useful for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.

    摘要翻译： 本发明提供了鉴定潜在地可用于治疗哺乳动物瘤形成的化合物的方法。 确定化合物的磷酸二酯酶抑制活性与COX抑制活性。 还测定了对培养的肿瘤细胞的生长抑制和凋亡诱导作用。 表现出磷酸二酯酶抑制，生长抑制和细胞凋亡诱导但不是实质性前列腺素抑制活性的化合物对于治疗瘤形成是理想的。

    Methods for identifying compounds for inhibiting of neoplastic lesions, and pharmaceutical compositions containing such compounds
    32.
    发明授权
    Methods for identifying compounds for inhibiting of neoplastic lesions, and pharmaceutical compositions containing such compounds 失效
    识别用于抑制肿瘤性病变的化合物的方法和含有这些化合物的药物组合物

    公开(公告)号：US06500610B1

    公开(公告)日：2002-12-31

    申请号：US09414625

    申请日：1999-10-08

    申请人： Rifat Pamukcu ,  Gary A. Piazza

    发明人： Rifat Pamukcu ,  Gary A. Piazza

    IPC分类号： C12Q144

    CPC分类号： G01N33/5011 ,  C12Q1/26 ,  C12Q1/44 ,  C12Q1/533

    摘要： This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but prefereably not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.

    摘要翻译： 本发明提供含有用于治疗哺乳动物瘤形成的化合物的药物组合物。 确定化合物的磷酸二酯酶抑制活性与COX抑制活性。 还测定了对培养的肿瘤细胞的生长抑制和凋亡诱导作用。 表现出磷酸二酯酶抑制，生长抑制和细胞凋亡诱导但优先不是实质性前列腺素抑制活性的化合物对于治疗瘤形成是理想的。