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    Polypeptides related to somatostatin
    31.
    发明授权
    Polypeptides related to somatostatin 失效
    与生长抑素相关的多肽

    公开(公告)号：US4209426A

    公开(公告)日：1980-06-24

    申请号：US42843

    申请日：1979-05-29

    Applicant: Dimitrios Sarantakis

    Inventor： Dimitrios Sarantakis

    IPC: A61K38/00 ,  C07K14/655 ,  C07C103/52 ,  A61K37/00

    CPC classification number: C07K14/6555 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16

    Abstract: Polypeptides of the formula: ##STR1## and the reduced linear form thereof, whereinX is H, Ala-Gly-, Ala-D-Ala, Gly-Gly-Gly-, acetyl or benzoyl;X.sub.4 is Arg or His;X.sub.8 is Trp or D-Trp;X.sub.14 is Cys or D-Cys,or a non-toxic acid addition salts thereof, inhibit the secretion of growth hormone, insulin and glucagon.

    Abstract translation: 式：其中X是H，Ala-Gly-，Ala-D-Ala，Gly-Gly-Gly-，乙酰基或苯甲酰基; X4是Arg或His; X8是Trp或D-Trp; X14是Cys或D-Cys，或其无毒的酸加成盐，抑制生长激素，胰岛素和胰高血糖素的分泌。

    Somatostatin analogs
    34.
    发明授权
    Somatostatin analogs 失效
    生长抑素类似物

    公开(公告)号：US4077952A

    公开(公告)日：1978-03-07

    申请号：US778517

    申请日：1977-03-17

    Applicant: Dimitrios Sarantakis

    Inventor： Dimitrios Sarantakis

    IPC: A61K38/00 ,  C07K14/655 ,  C07C103/52 ,  A61K37/00

    CPC classification number: C07K14/6555 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16

    Abstract: Somatostatin analogs which contain L-Arg.sup.4 -L-His.sup.5 amino acids residues in place of the normally present L-Lys.sup.4 -L-Asn.sup.5 residues are disclosed. Other modifications of somatostatin are also disclosed.These compounds inhibit the release of pituitary growth hormone, glucagon, and insulin.

    Abstract translation: 公开了含有L-Arg4-L-His5氨基酸残基代替通常存在的L-Lys4-L-Asn5残基的生长抑素类似物。 还公开了生长抑素的其它修饰。

    Cyclic somatostatin disulfide analogues
    36.
    发明授权
    Cyclic somatostatin disulfide analogues 失效
    循环生长抑素二硫化物类似物

    公开(公告)号：US3997517A

    公开(公告)日：1976-12-14

    申请号：US653685

    申请日：1976-01-30

    Applicant: Dimitrios Sarantakis

    Inventor： Dimitrios Sarantakis

    IPC: A61K38/00 ,  C07K14/655 ,  C07C103/52 ,  A61K37/00

    CPC classification number: C07K14/6555 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16

    Abstract: Cyclized somatostatin analogues containing the Cys-Cys disulfide linkage, their pharmaceutically acceptable acid addition salts as well as their cyclic disulfhydryl precursors and intermediates therefor are disclosed. The cyclized analogues of somatostatin selectively reduce blood serum concentrations of growth hormone without materially affecting the concentrations of glucagon or insulin.

    Abstract translation: 公开了包含Cys-Cys二硫键的环化生长抑素类似物，其药学上可接受的酸加成盐以及它们的环状二巯基前体及其中间体。 生长抑素的环化类似物选择性地降低生长激素的血清浓度，而不会严重影响胰高血糖素或胰岛素的浓度。

    (H-gly-gly-tyr-ala).sup.1 -somatostatin
    38.
    发明授权
    (H-gly-gly-tyr-ala).sup.1 -somatostatin 失效
    （H-gly-gly-tyr-ala）{hu 1 {b-促生长素抑制素

    公开(公告)号：US3931140A

    公开(公告)日：1976-01-06

    申请号：US544434

    申请日：1975-01-27

    Applicant: Dimitrios Sarantakis

    Inventor： Dimitrios Sarantakis

    IPC: A61K38/00 ,  C07K14/655 ,  C07C103/52 ,  A61K37/00

    CPC classification number: C07K14/655 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16

    Abstract: The growth hormone release inhibiting compound. ##EQU1## the protamine zinc, protamine aluminum and non-toxic acid addition salts thereof as well as the corresponding linear heptadecapeptide and intermediates therefore are herein described.

    Abstract translation: 生长激素释放抑制化合物。 H-Gly-Gly-Tyr-Ala-Gly-Cys-Lys-Asn-Phe- | S || | S | Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH 因此，本发明描述了鱼精蛋白铝及其无毒酸加成盐以及相应的线性十七肽和中间体。

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