公开(公告)号：US11024497B2

公开(公告)日：2021-06-01

申请号：US16808353

申请日：2020-03-03

Applicant: Ching Wu ,  Mark A. Osgood

Inventor： Ching Wu ,  Mark A. Osgood

IPC: H01J49/06 ,  H01J49/00 ,  C07B63/00 ,  G01N27/622

Abstract: An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.

公开(公告)号：US20190285583A1

公开(公告)日：2019-09-19

申请号：US16430309

申请日：2019-06-03

Applicant: Ching Wu ,  Mark A. Osgood ,  Eugenie Hainsworth ,  Clinton Alawn Krueger ,  Taeman Kim

Inventor： Ching Wu ,  Mark A. Osgood ,  Eugenie Hainsworth ,  Clinton Alawn Krueger ,  Taeman Kim

IPC: G01N27/62 ,  H01J49/16 ,  H01J49/06

Abstract: The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method. In addition, automation of the direct spray needle can be achieved by setting up array of the spray needles that are loaded in a manner that rotates and/or moves to the next spray needle in the ESI source region.

公开(公告)号：US20190259595A1

公开(公告)日：2019-08-22

申请号：US16396715

申请日：2019-04-28

Applicant: Ching Wu ,  Mark A. Osgood

Inventor： Ching Wu ,  Mark A. Osgood

IPC: H01J49/06 ,  G01N27/62 ,  C07B63/00 ,  H01J49/00

Abstract: An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.

公开(公告)号：US20160196964A1

公开(公告)日：2016-07-07

申请号：US14992053

申请日：2016-01-11

Applicant: Ching Wu ,  Mark A. Osgood

Inventor： Ching Wu ,  Mark A. Osgood

IPC: H01J49/06 ,  G01N27/62 ,  H01J49/00

CPC classification number: H01J49/061 ,  C07B63/00 ,  G01N27/622 ,  H01J49/0027

Abstract: The present invention uses an AC voltage instead of DC voltage on an ion gate to filter/selectively pass ions. The ions that pass through the AC ion gate can be further separated in a spectrometric instrument. An ion mobility spectrometer using the AC ion gate can achieve better gating performance. For a time of flight ion mobility spectrometer with an AC ion gate, a narrow pulse of selected ions can be passed into a drift tube where they are separated based on their low field ion mobility. Moreover, when the AC voltage at the AC ion gate has a waveform as used for differential ion mobility spectrometry, the time of flight ion mobility spectrometer is converted into a two dimensional separation spectrometer, where ions are first separated based on their high field ion mobility and then further separated based on their low field ion mobility.

Abstract translation: 本发明在离子浇口上使用交流电压而不是直流电压来过滤/选择性地通过离子。 通过AC离子浇口的离子可以在光谱仪器中进一步分离。 使用AC离子浇口的离子迁移谱仪可以获得更好的门控性能。 对于具有AC离子浇口的飞行时间离子迁移谱仪，选择的离子的窄脉冲可以被传送到漂移管中，基于它们的低场离子迁移率，它们被分离。 此外，当AC离子浇口处的AC电压具有用于差示离子迁移率光谱法的波形时，将飞行时间离子迁移谱仪转换成二维分离光谱仪，其中离子首先基于它们的高场离子迁移率而被分离 然后基于它们的低场离子迁移率进一步分离。

公开(公告)号：US09257269B2

公开(公告)日：2016-02-09

申请号：US13651837

申请日：2012-10-15

Applicant: Ching Wu

Inventor： Ching Wu

IPC: H01J49/10 ,  H01J49/16 ,  C07B63/00 ,  G01N27/62

CPC classification number: H01J49/165 ,  C07B63/00 ,  G01N27/622

Abstract: This invention describes an apparatus and method with a combined primary electrospray and secondary electrospray ionization source used to enhance ionization efficiency. The solid phase as well as liquid phase sampling, ionization, and detection is described.

Abstract translation: 本发明描述了一种用于提高电离效率的组合的初级电喷雾和次级电喷雾离子源的装置和方法。 描述了固相以及液相取样，电离和检测。

公开(公告)号：US08618477B2

公开(公告)日：2013-12-31

申请号：US13584388

申请日：2012-08-13

Applicant: Clinton Alawn Krueger ,  Ching Wu

Inventor： Clinton Alawn Krueger ,  Ching Wu

IPC: H01J49/26 ,  B01D59/44

CPC classification number: G01N27/622

Abstract: The present invention involves a series of shifting reagents that selectively interact with a targeted functional group of biological molecules, pharmaceutical drugs, small molecules, chemicals, chemical agents, or explosives resulting in a structure selective based drift time shift in the IMS. Additional energy is used to enhance the mobility based separation; in particular, the energy level can be tuned.

Abstract translation: 本发明涉及一系列转移试剂，其选择性地与生物分子，药物，小分子，化学品，化学试剂或爆炸物的目标官能团相互作用，导致IMS中基于结构选择性的漂移时间偏移。 使用额外的能量来增强基于移动性的分离; 特别地，可以调节能量水平。

公开(公告)号：US08492708B2

公开(公告)日：2013-07-23

申请号：US13360760

申请日：2012-01-29

Applicant: Ching Wu

Inventor： Ching Wu

IPC: H01J49/06 ,  H01J49/14 ,  G01N27/64

CPC classification number: G01N27/622

Abstract: Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independent operational conditions to separate charged particles based on their distinguishable chemical/physical properties. The first dimension drift chamber of this device can be used either as a storage device, a reaction chamber, and/or a drift chamber according to the operational mode of the analyzer. Also presented are various methods of operating an ion mobility spectrometer including, but not limited to, a continuous first dimension ionization methods that can enable ionization of all chemical components in the sample regardless their charge affinity.

Abstract translation: 公开了具有多于一个漂移室的多维离子迁移率分析仪的各种实施方案，并且可以获得物质的多维离子迁移谱。 该装置的漂移室可以例如在独立操作条件下操作，以根据其可区分的化学/物理性质分离带电粒子。 该装置的第一尺寸漂移室可以根据分析仪的操作模式用作存储装置，反应室和/或漂移室。 还提出了操作离子迁移谱仪的各种方法，包括但不限于连续的第一维电离方法，其能够使得样品中的所有化学组分电离，而不管其电荷亲和力如何。

公开(公告)号：US20120305761A1

公开(公告)日：2012-12-06

申请号：US13584388

申请日：2012-08-13

Applicant: Clinton Alawn Krueger ,  Ching Wu

Inventor： Clinton Alawn Krueger ,  Ching Wu

IPC: H01J49/04 ,  H01J49/26

CPC classification number: G01N27/622

Abstract: The present invention involves a series of shifting reagents that selectively interact with a targeted functional group of biological molecules, pharmaceutical drugs, small molecules, chemicals, chemical agents, or explosives resulting in a structure selective based drift time shift in the IMS. Additional energy is used to enhance the mobility based separation; in particular, the energy level can be tuned.

Abstract translation: 本发明涉及一系列转移试剂，其选择性地与生物分子，药物，小分子，化学品，化学试剂或爆炸物的目标官能团相互作用，导致IMS中基于结构选择性的漂移时间偏移。 使用额外的能量来增强基于移动性的分离; 特别地，可以调节能量水平。

公开(公告)号：US08314383B2

公开(公告)日：2012-11-20

申请号：US13083128

申请日：2011-04-08

Applicant: Ching Wu

Inventor： Ching Wu

IPC: H01J49/40 ,  H01J49/10 ,  G01N27/64

CPC classification number: G01N27/622 ,  H01J49/004

Abstract: This invention describes an ion mobility spectrometer system for chemical detection in the field. The system allows: a high throughput operation, an interface to new ionization methods, and an interface to a mass spectrometer.

Abstract translation: 本发明描述了一种用于现场化学检测的离子迁移谱仪系统。 该系统允许：高通量操作，与新离子化方法的接口以及与质谱仪的接口。

公开(公告)号：US20120228490A1

公开(公告)日：2012-09-13

申请号：US13419425

申请日：2012-03-13

Applicant: Ching Wu ,  Mark A. Osgood ,  Eugenie Hainsworth ,  Clinton Alawn Krueger ,  Taeman Kim

Inventor： Ching Wu ,  Mark A. Osgood ,  Eugenie Hainsworth ,  Clinton Alawn Krueger ,  Taeman Kim

IPC: H01J49/26

CPC classification number: G01N27/622 ,  G01N27/624 ,  H01J49/067 ,  H01J49/165

Abstract: The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.

Abstract translation: 本发明中描述的IMS装置和方法涉及将离子检测器设置在漂移管的最高电位并将电离源设置在接地或接地电位。 该方法允许显着简单的样品引入，而不受前端样品传送的高电位（电压）的限制。 本发明还描述了将样品直接引入离子迁移率漂移管中。 本发明还描述了通过电喷雾离子化方法使用单个注射器进行样品引入。