公开(公告)号：US20250020649A1

公开(公告)日：2025-01-16

申请号：US18789759

申请日：2024-07-31

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Saul Datwyler ,  Jaime Marino

IPC: G01N33/573 ,  A61B6/03 ,  A61B6/50 ,  G01N33/68

Abstract: Disclosed herein are methods that aid in the hyperacute diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild, moderate, severe, or moderate to severe traumatic brain injury (TBI), using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed here are methods that aid in the hyperacute determination of whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting changes of levels of an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof, in samples taken from a human subject at a time point within about 2 hours, such as about 10, 12, or 20 minutes, after the subject has sustained or may have sustained an injury to the head and a second time point about 3 hours to about 6 hours after the first sample is taken.

公开(公告)号：US12178592B2

公开(公告)日：2024-12-31

申请号：US17411511

申请日：2021-08-25

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Frederick Korley ,  Agim Beshiri ,  Jaime Marino ,  Saul Datwyler

IPC: A61B5/00 ,  C12Q1/6883 ,  G01N33/543 ,  G01N33/564 ,  G01N33/577 ,  G01N33/68 ,  G01N33/533

Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using cTnI. Also disclosed are methods for determining whether to perform a head computerized tomography on a subject by detecting levels of cTnI. Finally, also disclosed are methods of outcome in subjects suffering from a mild TBI.

公开(公告)号：US12163958B2

公开(公告)日：2024-12-10

申请号：US17316230

申请日：2021-05-10

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Saul Datwyler ,  Jaime Marino

IPC: G01N33/573 ,  A61B6/03 ,  A61B6/50 ,  G01N33/68

Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate to severe traumatic brain injury (TBI), using an early biomarker, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1). Also disclosed here are methods that aid in determining whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels and changes in levels of UCH-L1 in one or more samples taken from a human subject at time points within 24 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US20240393334A1

公开(公告)日：2024-11-28

申请号：US18743218

申请日：2024-06-14

Applicant: Abbott Laboratories

Inventor： Tony K. Lee ,  Peter J. Karabatsos ,  Andrew S. Schapals ,  Antti Virtanen ,  Beth McQuiston ,  Craig A. Jeffrey ,  Alison Taylor ,  Raj Chandran ,  Jaime Marino ,  Saul Datwyler

IPC: G01N33/573 ,  A61B5/15 ,  G01N33/68 ,  G01N33/76 ,  G01N33/78

Abstract: Disclosed herein are systems and methods for determining ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof in a blood sample obtained from a subject. Also disclosed herein are systems and methods for determining CK-MB, β-hCG, thyroid stimulating hormone (TSH), homocysteine, free thyroxine (free T4) or any combinations thereof in a blood sample.

公开(公告)号：US12105100B2

公开(公告)日：2024-10-01

申请号：US17316257

申请日：2021-05-10

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran ,  Jaime Marino

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N33/6893 ,  G01N2800/28 ,  G01N2800/2871 ,  G01N2800/60

Abstract: Disclosed herein are methods of aiding in the diagnosis and evaluation of a subject that has sustained or may have sustained an injury to the head. For example, the present disclosure provides methods for aiding in the diagnosis and evaluation of a subject to determine whether the subject has sustained a traumatic brain injury (TBI) by detecting or measuring a combination of the levels of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in samples taken at various time points within 48 hours after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US12099069B2

公开(公告)日：2024-09-24

申请号：US17104886

申请日：2020-11-25

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Justin Rogers ,  Saul Datwyler ,  Jaime Marino

IPC: G01N33/68 ,  G01N33/573

CPC classification number: G01N33/6896 ,  G01N33/573 ,  C12Y301/02015 ,  G01N2333/916 ,  G01N2333/948 ,  G01N2800/28 ,  G01N2800/50

Abstract: Disclosed herein are methods that aid in the hyperacute diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed here are methods that aid in the hyperacute determination of whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1. These methods involve detecting levels of early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP), or a combination thereof, in samples taken from a human subject at a time point within about 2 hours, such as about 10, 12, or 20 minutes, after the subject has sustained or may have sustained an injury to the head.

公开(公告)号：US20240118279A1

公开(公告)日：2024-04-11

申请号：US17839669

申请日：2022-06-14

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Saul Datwyler ,  Jaime Marino

IPC: G01N33/573 ,  G01N33/68

CPC classification number: G01N33/573 ,  G01N33/6893 ,  G01N2333/948 ,  G01N2800/28 ,  G01N2800/40

Abstract: Disclosed herein are methods of aiding in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head, such as mild, moderate, severe, or moderate to severe traumatic brain injury (TBI) by detecting levels of a biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP), or a combination thereof, in samples taken from a subject (e.g., a human subject) that has or may have sustained an injury or suspected injury to the head that is caused or believed to have been caused by acoustic energy, electromagnetic energy (e.g., from a sonic weapon, a directed energy weapon or a combination thereof), an over pressurization wave, blast wind, or any combination thereof.

公开(公告)号：US20240094226A1

公开(公告)日：2024-03-21

申请号：US18509717

申请日：2023-11-15

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Saul Datwyler ,  Raj Chandran ,  Jaime Marino ,  Hongwei Zhang

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/916 ,  G01N2333/948 ,  G01N2800/28 ,  G01N2800/50

Abstract: Disclosed herein are methods of determining whether a subject has a traumatic brain injury (TBI) by detecting levels of at least one biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP), or a combination thereof, in samples taken from a subject.

公开(公告)号：US11931161B2

公开(公告)日：2024-03-19

申请号：US17084568

申请日：2020-10-29

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Frederick Korley ,  Agim Beshiri ,  Jaime Marino ,  Saul Datwyler

IPC: A61B5/00 ,  C12Q1/6883 ,  G01N33/543 ,  G01N33/564 ,  G01N33/577 ,  G01N33/68 ,  G01N33/533

CPC classification number: A61B5/4064 ,  G01N33/54346 ,  G01N33/54366 ,  G01N33/577 ,  G01N33/6896 ,  C12Q1/6883 ,  G01N33/533 ,  G01N33/564 ,  G01N33/6893 ,  G01N2800/28 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60

Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or a moderate, severe, or moderate to severe traumatic brain injury (TBI), by detecting levels of cardiac troponin I (cTnI) and one or more early biomarkers which are not cTnI, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof, in biological samples taken from a human subject at time points within about 24 hours of injury after the subject has sustained or may have sustained the injury to the head.

公开(公告)号：US11129564B2

公开(公告)日：2021-09-28

申请号：US15993589

申请日：2018-05-30

Applicant: Abbott Laboratories

Inventor： Beth McQuiston ,  Frederick Korley ,  Agim Beshiri ,  Jaime Marino ,  Saul Datwyler

IPC: A61K38/00 ,  C12Q1/68 ,  G01N33/567 ,  A61B5/00 ,  G01N33/68 ,  G01N33/543 ,  G01N33/577 ,  C12Q1/6883 ,  G01N33/533 ,  G01N33/564

Abstract: Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using cTnI. Also disclosed are methods for determining whether to perform a head computerized tomography on a subject by detecting levels of cTnI. Finally, also disclosed are methods of outcome in subjects suffering from a mild TBI.