知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

44 records (took 0.041 seconds)

    ISOLATED HIGH AFFINITY ENTITIES WITH T-CELL RECEPTOR LIKE SPECIFICITY TOWARDS NATIVE COMPLEXES OF MHC CLASS II AND GLUTAMIC ACID DECARBOXYLASE (GAD) AUTOANTIGENIC PEPTIDES
    31.
    发明申请
    ISOLATED HIGH AFFINITY ENTITIES WITH T-CELL RECEPTOR LIKE SPECIFICITY TOWARDS NATIVE COMPLEXES OF MHC CLASS II AND GLUTAMIC ACID DECARBOXYLASE (GAD) AUTOANTIGENIC PEPTIDES 有权
    具有T细胞受体特异性的分离的高亲和性实体涉及MHC II类和谷氨酸脱羧酶（GAD）自身抗原肽的本体复合物

    公开(公告)号：US20130115218A1

    公开(公告)日：2013-05-09

    申请号：US13810266

    申请日：2011-07-14

    Applicant: Yoram Reiter ,  Rony Dahan

    Inventor： Yoram Reiter ,  Rony Dahan

    IPC: C12N9/88 ,  C07K16/40

    CPC classification number: C12N9/88 ,  C07K16/2833 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2319/32 ,  C07K2319/40 ,  C07K2319/73 ,  C12N15/62

    Abstract: Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated GAD autoantigenic peptide, the isolated complex having a structural conformation which enables isolation of a high affinity entity which comprises an antigen binding domain capable of specifically binding to a native conformation of a complex composed of the MHC class II and the type I diabetes-associated GAD autoantigenic peptide; and isolated high affinity entities comprising an antigen binding domain capable of specifically binding the complex, wherein the isolated high affinity entity does not bind to the MHC class II in an absence of the diabetes-associated GAD autoantigenic peptide, wherein the isolated high affinity entity does not bind to the diabetes-associated GAD autoantigenic peptide in an absence of the MHC class II; and methods and kits using same for diagnostic and therapeutic purposes.

    Abstract translation: 提供了包含主要组织相容性复合体（MHC）II类和I型糖尿病相关GAD自身抗原肽的分离的复合物，所述分离的复合物具有能够分离高亲和力实体的结构构象，其包含能够特异性结合的抗原结合结构域 涉及由MHC II类和I型糖尿病相关的GAD自身抗原肽组成的复合物的天然构象; 和分离的高亲和力实体，其包含能够特异性结合复合物的抗原结合结构域，其中所述分离的高亲和性实体在不存在与糖尿病相关的GAD自身抗原肽的情况下不结合MHC II类，其中所述分离的高亲和力实体 在不存在MHC II类的情况下不与糖尿病相关的GAD自身抗原肽结合; 以及用于诊断和治疗目的的方法和试剂盒。

    FUSION PROTEINS, USES THEREOF AND PROCESSES FOR PRODUCING SAME
    33.
    发明申请
    FUSION PROTEINS, USES THEREOF AND PROCESSES FOR PRODUCING SAME 审中-公开
    融合蛋白，其用途及其生产方法

    公开(公告)号：US20110150874A1

    公开(公告)日：2011-06-23

    申请号：US12972560

    申请日：2010-12-20

    Applicant: Yoram Reiter ,  Roy Noy ,  Kfir Oved

    Inventor： Yoram Reiter ,  Roy Noy ,  Kfir Oved

    IPC: A61K39/395 ,  C07K19/00 ,  C07H21/00 ,  C12N15/63 ,  C12P21/00 ,  A61P35/00 ,  C12N5/10 ,  C12N1/00

    CPC classification number: C12N15/62 ,  A61K2039/505 ,  C07K14/70539 ,  C07K16/30 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/33

    Abstract: This invention provides fusion proteins comprising consecutive amino acids which beginning at the amino terminus of the protein correspond to consecutive amino acids present in (i) a cytomegalovirus human MHC-restricted peptide, (ii) a first peptide linker, (iii) a human β-2 microglobulin, (iv) a second peptide linker, (v) a HLA-A2 chain of a human MHC class I molecule, (vi) a third peptide linker, (vii) a variable region from a heavy chain of a scFv fragment of an antibody, and (viii) a variable region from a light chain of such scFv fragment, wherein the consecutive amino acids which correspond to (vii) and (viii) are bound together directly by a peptide bond or by consecutive amino acids which correspond to a fourth peptide linker, wherein the antibody from which the scFv fragment is derived specifically binds to mesothelin. This invention provides nucleic acid constructs encoding same, processes for producing same, compositions, and uses thereof.

    Abstract translation: 本发明提供了包含连续氨基酸的融合蛋白，其开始于蛋白质的氨基末端，对应于（i）巨细胞病毒人MHC限制肽中存在的连续氨基酸，（ii）第一肽接头，（iii）人类 ; -2微球蛋白，（iv）第二肽接头，（v）人MHC I类分子的HLA-A2链，（vi）第三肽接头，（vii）来自scFv重链的可变区 抗体的片段，和（viii）来自这种scFv片段的轻链的可变区，其中对应于（vii）和（viii）的连续氨基酸直接通过肽键或连续的氨基酸连接在一起 对应于第四肽接头，其中衍生scFv片段的抗体特异性结合间皮素。 本发明提供了编码其的核酸构建体，其生产方法，组合物和用途。

    METHODS OF DIAGNOSING AND TREATING CYTOMEGALOVIRUS DISEASES
    34.
    发明申请
    METHODS OF DIAGNOSING AND TREATING CYTOMEGALOVIRUS DISEASES 失效
    诊断和治疗细胞病毒性疾病的方法

    公开(公告)号：US20100111957A1

    公开(公告)日：2010-05-06

    申请号：US12450476

    申请日：2008-03-27

    Applicant: Oryan Makler ,  Yoram Reiter

    Inventor： Oryan Makler ,  Yoram Reiter

    IPC: A61K39/395 ,  C07K16/08 ,  C12Q1/70

    CPC classification number: C07K16/088 ,  A61K2039/505 ,  C07K16/2833 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/55 ,  C07K2317/92

    Abstract: Anti CMV antibodies are provided. Thus an antibody of the present invention comprises an antigen recognition domain capable of binding an MHC molecule being complexed with a cytomegalovirus (CMV) pp65 or pp64 peptide, wherein the antibody does not bind said MHC molecule in an absence of said complexed peptide, and wherein the antibody does not bind said peptide in an absence of said MHC molecule. Also provided are methods of using the antibodies.

    Abstract translation: 提供抗CMV抗体。 因此，本发明的抗体包含能够结合与巨细胞病毒（CMV）pp65或pp64肽复合的MHC分子的抗原识别结构域，其中所述抗体在不存在所述复合肽的情况下不结合所述MHC分子，并且其中 在不存在所述MHC分子的情况下，抗体不结合所述肽。 还提供了使用抗体的方法。

    Artificial receptors
    36.
    发明申请
    Artificial receptors 有权
    人造受体

    公开(公告)号：US20090306578A1

    公开(公告)日：2009-12-10

    申请号：US12311216

    申请日：2007-09-20

    Applicant: Uri Sivan ,  Yoram Reiter ,  Arbel Artzy-Schnirman

    Inventor： Uri Sivan ,  Yoram Reiter ,  Arbel Artzy-Schnirman

    IPC: A61N1/18 ,  C07K16/00 ,  B01J19/12

    CPC classification number: G01N33/5438

    Abstract: Antibodies are provided. For as example, an antibody capable of binding an artificial receptor which comprises a hydroquinone monolayer and is incapable of binding the artificial receptor when comprising a benzoquinone monolayer. Also provided are methods and systems using same for control delivery of a molecule-of-interest into a tissue.

    Abstract translation: 提供抗体。 例如，能够结合人造受体的抗体，其包含氢醌单层，当包含苯醌单层时不能与人造受体结合。 还提供了使用它们的方法和系统来控制将感兴趣的分子传递到组织中。

    Single chain class I major histocompatibility complexes
    37.
    发明申请
    Single chain class I major histocompatibility complexes 审中-公开
    单链I类主要组织相容性复合物

    公开(公告)号：US20090148925A1

    公开(公告)日：2009-06-11

    申请号：US12213368

    申请日：2008-06-18

    Applicant: Yoram Reiter

    Inventor： Yoram Reiter

    IPC: C12N1/21 ,  C12N15/11

    CPC classification number: C07K14/70539

    Abstract: A recombinant polypeptide and nucleic acid constructs capable of expressing the recombinant polypeptide are provided. The recombinant polypeptide comprises a chimeric polypeptide including an antigenic peptide being capable of binding a human MHC class I, a functional human β-2 microglobulin and a functional human MHC class I heavy chain.

    Abstract translation: 提供能够表达重组多肽的重组多肽和核酸构建体。 重组多肽包含嵌合多肽，其包括能够结合人MHC I类，功能性人β-2微球蛋白和功能性人MHC I类重链的抗原肽。

Patent Agency Ranking