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公开(公告)号：US4518589A
公开(公告)日：1985-05-21
申请号：US538453
申请日：1983-10-03
IPC分类号： C12P19/46 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/04 , A61P35/00 , C07H17/04 , C12P19/60 , C12R1/01 , C12R1/04 , C12R1/465 , C12R1/52 , A61K31/71 , C07H15/24
摘要： A novel antibiotic complex designated BBM-2478 is produced by fermentation of an actinomycete strain J907-21 (ATCC 39417). The complex may be separated chromatographically into two bioactive components designated BBM-2478A and BBM-2478B. The BBM-2478A component displays both antibacterial and antitumor activity while the BBM-2478B component has antibacterial activity.
摘要翻译： 通过放线菌菌株J907-21（ATCC 39417）的发酵产生了称为BBM-2478的新型抗生素复合物。 该复合物可以色谱分离成两种生物活性成分，称为BBM-2478A和BBM-2478B。 BBM-2478A组分显示抗菌和抗肿瘤活性，而BBM-2478B组分具有抗菌活性。
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公开(公告)号：US4360593A
公开(公告)日：1982-11-23
申请号：US346451
申请日：1982-02-08
CPC分类号： C12R1/09 , C07K7/62 , A61K38/00 , Y10S435/835
摘要： A novel peptide antibiotic complex designated herein as Bu-2470 is produced by fermentation of Bacillus circulans strain G493-B6 (ATCC 31,805). Complex Bu-2470 may be separated into four bioactive peptide antibiotics designated as Bu-2470A, B.sub.1, B.sub.2a, and B.sub.2b. The complex and individual bioactive factors possess significant antimicrobial activity.
摘要翻译： 本文命名为Bu-2470的新型肽抗生素复合物是通过环状芽孢杆菌菌株G493-B6（ATCC 31,805）的发酵产生的。 复合物Bu-2470可以分成四种被称为Bu-2470A，B1，B2a和B2b的生物活性肽抗生素。 复杂和个体的生物活性因子具有显着的抗菌活性。
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公开(公告)号：US5098708A
公开(公告)日：1992-03-24
申请号：US546463
申请日：1990-07-06
IPC分类号： C12P1/06
CPC分类号： C12P1/06 , Y10S435/822 , Y10S435/826
摘要： Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.
摘要翻译： 公开了通过新型微生物Amycolatopsis orientalis ATCC-53884的BU-3889V生产菌株的发酵生产抗病毒抗生素复合物BU-3889V及其生物活性成分A1，A2，A3，D1，D2和D3。 通过使用离子交换色谱技术分离复合物BU-3889V并将组分分离。 生物活性成分的特征在于其物理化学性质。 已经发现这些产品有效地抑制包括单纯疱疹病毒，人类免疫缺陷病毒（HIV）和流感病毒在内的病毒。
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34.发明授权Process for preparing an antibiotic complex by culturing actinomyces strain ATCC 39417 失效通过培养放线菌菌株ATCC 39417制备抗生素复合物的方法
公开(公告)号：US4572895A
公开(公告)日：1986-02-25
申请号：US690283
申请日：1985-02-19
CPC分类号： C07H17/04 , C12P19/60 , C12R1/465 , Y10S435/822 , Y10S435/826
摘要： A novel antibiotic complex designated BBM-2478 is produced by fermentation of an actinomycete strain J907-21 (ATCC 39417). The complex may be separated chromatographically into two bioactive components designated BBM-2478A and BBM-2478B. The BBM-2478A component displays both antibacterial and antitumor activity while the BBM-2478B component has antibacterial activity.
摘要翻译： 通过放线菌菌株J907-21（ATCC 39417）的发酵产生了称为BBM-2478的新型抗生素复合物。 该复合物可以色谱分离成两种生物活性成分，称为BBM-2478A和BBM-2478B。 BBM-2478A组分显示抗菌和抗肿瘤活性，而BBM-2478B组分具有抗菌活性。
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公开(公告)号：US4314028A
公开(公告)日：1982-02-02
申请号：US109427
申请日：1980-01-03
CPC分类号： C07H15/26 , Y10S435/822
摘要： Addition of certain amine precursor compounds to the culture medium during fermentation of a tallysomycin-producing strain of Streptoalloteichus hindustanus results in production of new tallysomycin derivatives having advantageous antimicrobial and antitumor properties.
摘要翻译： 在培养的产丝菌霉素生产菌株Streptoalloteichus hindustanus的发酵期间向培养基中加入某些胺前体化合物导致产生具有有利的抗微生物和抗肿瘤性质的新的菌丝霉素衍生物。
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