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36 条记录 (耗时 0.017 秒)

    Combination therapeutic compositions and method of use
    31.
    发明授权
    Combination therapeutic compositions and method of use 有权

    公开(公告)号：US06653332B2

    公开(公告)日：2003-11-25

    申请号：US09847887

    申请日：2001-05-02

    申请人： Juan C. Jaen ,  Jin-Long Chen

    发明人： Juan C. Jaen ,  Jin-Long Chen

    IPC分类号： A61K3144

    CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/165 ,  A61K31/47 ,  Y10S514/866 ,  A61K2300/00

    摘要： The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, &agr;-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.

    UCP3 genes
    32.
    发明授权
    UCP3 genes 失效
    UCP3基因

    公开(公告)号：US06248561B1

    公开(公告)日：2001-06-19

    申请号：US09503579

    申请日：2000-02-14

    申请人： Ning Zhang ,  M. Catherine Amaral ,  Jin-Long Chen

    发明人： Ning Zhang ,  M. Catherine Amaral ,  Jin-Long Chen

    IPC分类号： C12P2102

    CPC分类号： C07K14/47 ,  A01K2217/075 ,  A61K38/00

    摘要： The invention provides methods and compositions relating to a novel family of UCP3 polypeptides and related nucleic acids involved in metabolic regulation. The polypeptides may be produced recombinantly from transformed host cells from the disclosed mUCP3 encoding nucleic acids or purified from mammalian cells. The invention provides isolated mUCP3 hybridization probes, knock-out/in constructs and primers capable of specifically hybridizing with the disclosed mUCP3 genes, mUCP3-specific binding agents such as specific antibodies, animals and cells modified with the subject mUCP3 nucleic acids, and methods of making and using the subject compositions in the biopharmaceutical industry.

    摘要翻译： 本发明提供与涉及代谢调节的UCP3多肽的新家族和相关核酸有关的方法和组合物。 可以从编码核酸的公开的mUCP3或从哺乳动物细胞纯化的转化的宿主细胞重组产生多肽。 本发明提供分离的mUCP3杂交探针，能够与所公开的mUCP3基因，mUCP3特异性结合剂如特异性抗体，用受试者mUCP3核酸修饰的动物和细胞特异性杂交的敲除/ in构建体和引物，以及 制作和使用生物制药工业中的主题组合物。

    Murine UCP3 polypeptides
    34.
    发明授权
    Murine UCP3 polypeptides 失效
    鼠UCP3多肽

    公开(公告)号：US6025469A

    公开(公告)日：2000-02-15

    申请号：US318199

    申请日：1999-05-25

    申请人： Ning Zhang ,  M. Catherine Amaral ,  Jin-Long Chen

    发明人： Ning Zhang ,  M. Catherine Amaral ,  Jin-Long Chen

    IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K16/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02

    CPC分类号： C07K14/47 ,  A01K2217/075 ,  A61K38/00

    摘要： The invention provides methods and compositions relating to a novel family of UCP3 polypeptides and related nucleic acids involved in metabolic regulation. The polypeptides may be produced recombinantly from transformed host cells from the disclosed mUCP3 encoding nucleic acids or purified from mammalian cells. The invention provides isolated mUCP3 hybridization probes, knock-out/in constructs and primers capable of specifically hybridizing with the disclosed mUCP3 genes, mUCP3-specific binding agents such as specific antibodies, animals and cells modified with the subject mUCP3 nucleic acids, and methods of making and using the subject compositions in the biopharmaceutical industry.

    摘要翻译： 本发明提供与涉及代谢调节的UCP3多肽的新家族和相关核酸有关的方法和组合物。 可以从编码核酸的公开的mUCP3或从哺乳动物细胞纯化的转化的宿主细胞重组产生多肽。 本发明提供分离的mUCP3杂交探针，能够与所公开的mUCP3基因，mUCP3特异性结合剂如特异性抗体，用受试者mUCP3核酸修饰的动物和细胞特异性杂交的敲除/ in构建体和引物，以及 制作和使用生物制药工业中的主题组合物。