公开(公告)号：US09878049B2

公开(公告)日：2018-01-30

申请号：US14510442

申请日：2014-10-09

Applicant: Gang Cheng ,  Qiong Tang ,  Bin Cao

Inventor： Gang Cheng ,  Qiong Tang ,  Bin Cao

IPC: C12N15/11 ,  A61K47/48 ,  A61K31/4745 ,  A61K45/06 ,  A61K31/713 ,  A61K47/59 ,  A61K47/64

CPC classification number: A61K47/59 ,  A61K31/4745 ,  A61K31/713 ,  A61K45/06 ,  A61K47/645 ,  A61K2300/00

Abstract: A high drug loading system is described comprising of at least one anticancer drug; at least one peptide; and at least one nucleic acid.

公开(公告)号：US20150231274A1

公开(公告)日：2015-08-20

申请号：US14621904

申请日：2015-02-13

Applicant: Gang Cheng ,  Qiong Tang ,  Bin Cao

Inventor： Gang Cheng ,  Qiong Tang ,  Bin Cao

IPC: A61K47/48 ,  A61K48/00

CPC classification number: A61K47/645 ,  A61K47/61 ,  C12N15/87 ,  C12N2810/40

Abstract: One or more embodiments of the present invention provide a novel composition for gene delivery are directed to a group of polysaccharide polymers, having one or more nucleic acid delivery side chains comprising cationic peptides. In some embodiments, these cationic peptides condense and physically bond to one or more nucleic acids to form a polysaccharide-nucleic acid complex that permits delivery to and transfection of the nucleic acid(s) into cells. In some embodiments, the polysaccharide polymers of the present invention may also have one or more zwitterionic side chains and/or reactive side chains.

Abstract translation: 本发明的一个或多个实施方案提供用于基因递送的新组合物涉及一组多糖聚合物，其具有一个或多个包含阳离子肽的核酸递送侧链。 在一些实施方案中，这些阳离子肽缩合并物理键合到一个或多个核酸以形成允许将核酸递送至细胞并将其转染入细胞的多糖 - 核酸复合物。 在一些实施方案中，本发明的多糖聚合物也可以具有一个或多个两性离子侧链和/或反应性侧链。

公开(公告)号：US20140050237A1

公开(公告)日：2014-02-20

申请号：US13586090

申请日：2012-08-15

Applicant: Bin CAO ,  Douglas J.S. BECKETT ,  David NICHOLSON

Inventor： Bin CAO ,  Douglas J.S. BECKETT ,  David NICHOLSON

IPC: H01S3/10

CPC classification number: H01S5/4006 ,  H01S5/0064 ,  H01S5/0078 ,  H01S5/0612

Abstract: A discretely tunable locally seeded laser device is provided. The discretely tunable locally seeded laser device comprises: a first tunable laser comprising first discrete output modes; and, a second tunable laser arranged to receive output from the first tunable laser, but otherwise optically isolated from the first tunable laser, the second tunable laser comprising second discrete output modes, such that one first discrete output mode can optically seed an aligned second discrete output mode in a given position of one or more of the first discrete output modes and the second discrete output modes, the aligned second discrete output mode comprising a dominant output.

Abstract translation: 提供离散可调谐的本地种子激光器件。 离散可调本地种子激光器件包括：第一可调谐激光器，包括第一离散输出模式; 以及第二可调谐激光器，其布置成接收来自所述第一可调谐激光器的输出，但是否则与所述第一可调谐激光器光学隔离，所述第二可调谐激光器包括第二离散输出模式，使得一个第一离散输出模式可光学地种子对准的第二离散 输出模式在一个或多个第一离散输出模式和第二离散输出模式的给定位置中，所对齐的第二离散输出模式包括主要输出。

公开(公告)号：US20130277212A1

公开(公告)日：2013-10-24

申请号：US13520932

申请日：2011-01-07

Applicant: Bin Cao ,  Tao Yang

Inventor： Bin Cao ,  Tao Yang

IPC: C25C7/02

CPC classification number: C25C7/02 ,  C25C3/08

Abstract: A cathode boss structure for an aluminum electrolytic cell is disclosed. The cathode boss is arranged on the top surface of the cathode carbon block or on the top of the gap between two cathode carbon blocks. The distance between cathode bosses is 400 mm-900 mm. The length of the throughout elongate cathode boss is 100-250 mm longer than that of cathode carbon block, and two ends thereof are directly embedded into the paste around lateral portion. The length of the embedded and butted cathode boss is in a range of 3000-3200 mm, two ends thereof are fixed by binding carbon blocks respectively, and the binding carbon blocks are embedded into the paste around lateral portion. The cross-section of the cathode boss structure is in the shape of rectangle or isosceles trapezoid. The cathode boss structure is applicable to all types of current electrolytic cells. The strip boss is implanted into the top surface of the cathode of the electrolytic cell conveniently and quickly when the lateral portion of the common electrolytic cell is rammed, thereby forming a “choking effect”, reducing the flow rate of the aluminum liquid layer, decreasing energy dissipation from the aluminum liquid layer, therefore improving the production stability of the electrolytic cell and reducing energy consumption.

Abstract translation: 公开了一种用于铝电解槽的阴极凸起结构。 阴极凸台布置在阴极碳块的顶表面上或两个阴极碳块之间的间隙顶部。 阴极凸台之间的距离为400mm-900mm。 整个细长阴极凸台的长度比阴极碳块的长度长100-250毫米，其两端直接嵌入围绕侧面部分的浆料中。 嵌入和对接的阴极凸台的长度在3000-3200mm的范围内，其两端分别通过粘结碳块固定，并且结合碳块被嵌入周围的浆料中。 阴极凸台结构的横截面呈矩形或等腰梯形。 阴极凸台结构适用于所有类型的电流电解槽。 当公共电解池的侧面部分被夯实时，带状凸起被方便且快速地注入电解槽阴极的上表面，从而形成“窒息效应”，从而降低铝液层的流速，降低 从铝液层消耗能量，从而提高电解槽的生产稳定性，降低能耗。

公开(公告)号：US20120305630A1

公开(公告)日：2012-12-06

申请号：US13512217

申请日：2010-11-17

Applicant: Tao Yang ,  Bin Cao

Inventor： Tao Yang ,  Bin Cao

IPC: B23K31/12 ,  B23K37/00 ,  B23K31/02

CPC classification number: C25C3/16 ,  B23K2103/10

Abstract: A device using the live welding method for aluminum electrolytic cell overhauling under series full current consists of short-circuit buses at the bottom of the cell (1), pillar buses (2), an anode bus (3), a balance bus (4), a inter-cell standby bus (5), a door-shaped pillar clamp (6), an arcuate clamp (7) of anode buses, a current conversion switch (8, a mechanical switching device (9) for the short-circuit port, a voltage sensor and wires thereof (10), a temperature sensor and wires thereof (11), a system (12) for data acquiring, displaying, analyzing and alarming, an A-side welding area (13), a B-side welding area (14) and compression-joint points (15) on pillar soft belts of overhauling cells; and the live welding method comprises the following steps: when welding is required to be performed in some zone, the currents of short-circuit buses at the bottom of the cell (1) and pillar buses (2) which influence the welding area most are cut off, the serial currents are shunted to other pillar buses (2), other buses at the bottom of the cell (1) and the inter-cell standby buses (5) such that the magnetic field intensity at the welding area can be lowered to the extent that welding can be performed so as to perform welding, and such a device and method can achieve live welding of aluminum electrolytic cells overhauling under series full current.

Abstract translation: 在串联全电流下使用铝电解电池检修的活焊方法的装置由电池底部的短路母线（1），支柱母线（2），阳极母线（3），平衡母线（4） ），单元间备用总线（5），门形柱式夹具（6），阳极母线的弓形夹具（7），电流转换开关（8），用于短路模块的机械开关装置（9） 电路端口，电压传感器及其电线（10），温度传感器及其电线（11），用于数据采集，显示，分析和报警的系统（12），A侧焊接区域（13），B 侧面焊接区域（14）和压缩接头点（15），活塞焊接方法包括以下步骤：当需要在某些区域进行焊接时，短路电流 电池底部的总线（1）和影响焊接区域的柱式总线（2）被切断，串联电流分流到其他 支柱总线（2），电池底部的其他总线（1）和电池间备用总线（5），使得焊接区域的磁场强度可以降低到可以进行焊接的程度，以便 进行焊接，这种装置和方法可以在串联全电流下实现铝电解电池的检修。

公开(公告)号：US20110182307A1

公开(公告)日：2011-07-28

申请号：US13082690

申请日：2011-04-08

Applicant: Bin CAO ,  Douglas James BECKETT ,  Tom LUK ,  Rong CHEN

Inventor： Bin CAO ,  Douglas James BECKETT ,  Tom LUK ,  Rong CHEN

IPC: H01S3/13 ,  H01S3/063

CPC classification number: H01S5/0683 ,  H01S5/06804

Abstract: A method of estimating an injection power of seed light injected into an injection-seeded transmitter. A back face monitoring (BFM) response of the injection-seeded transmitter is determined, and data representative of the BFM response stored in a memory. During run-time, a controller of the injection-seeded transmitter, detects a temperature of the injection-seeded transmitter and an instantaneous BFM current. BFM response data is obtained from the memory based on the detected temperature, and the seed light injection power estimated based on the obtained data and the detected instantaneous BFM current.

Abstract translation: 一种估计注入种子发射机的种子光的注入功率的方法。 确定注入种子发送器的背面监视（BFM）响应，并将表示BFM响应的数据存储在存储器中。 在运行期间，注入种子发射机的控制器检测注入种子发射机的温度和瞬时BFM电流。 基于检测到的温度从存储器获得BFM响应数据，并且基于获得的数据估计的种子光注入功率和检测到的瞬时BFM电流。

公开(公告)号：US07517889B2

公开(公告)日：2009-04-14

申请号：US11735760

申请日：2007-04-16

Applicant: Keith John Harris ,  Bin Cao

Inventor： Keith John Harris ,  Bin Cao

IPC: C07D239/46 ,  A61K31/505

CPC classification number: C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).

Abstract translation: 本发明涉及式（I）的化合物，其中Cy1，Cy2，L1，L2和R1如本文所定义，药物组合物包含药学上有效量的一种或多种式（I）化合物的混合物 与药学上可接受的载体和治疗患有PGD2介导的病症的患者的方法，包括但不限于过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症 ，伴有系统性肥大细胞活化，过敏性休克，支气管收缩，支气管炎，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍） 由于伴随瘙痒的行为（如刮伤和跳动），炎症，慢性阻塞性肺疾病 脑缺血再灌注损伤，脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎等，通过向所述患者施用药学有效量的根据式（I）的化合物。

公开(公告)号：US20080010680A1

公开(公告)日：2008-01-10

申请号：US11691155

申请日：2007-03-26

Applicant: Bin Cao ,  Yong Wang

Inventor： Bin Cao ,  Yong Wang

IPC: G06F11/00

CPC classification number: H04L63/1416 ,  G06F21/554

Abstract: The embodiments of the present invention disclose an event detection method and device. The method includes: predefining event-based detection rules with a predicative context-free grammar; generating by parsing the detection rules a parsing table of pushdown automaton which supports parallel parsing; receiving an event to be detected; and analyzing by a controller the event to be detected according to the parsing table, to obtain a detection result. The present invention is especially applicable to detection of network attack events. The embodiments of the present invention detect the attacks with a predicative context-free grammar on the basis of events, and ensure a close combination of a protocol parsing process and an attack detection process, as well as a close combination of multiple attack detection rules, thus decreasing unnecessary calculations. In addition, with an optimized parallel pushdown automaton, the embodiments of the present invention can efficiently analyze the predicative context-free grammar. Consequently, besides hierarchical processing capability and state description capability, the embodiments of the present invention deliver high efficiency.

Abstract translation: 本发明的实施例公开了一种事件检测方法和装置。 该方法包括：使用预测上下文无关语法预定义基于事件的检测规则; 通过解析检测规则生成支持并行解析的下推自动机的解析表; 接收要检测的事件; 并由控制器根据解析表分析要检测的事件，以获得检测结果。 本发明特别适用于网络攻击事件的检测。 本发明的实施例基于事件来检测具有谓词上下文无关语法的攻击，并且确保协议解析过程和攻击检测过程的紧密组合以及多个攻击检测规则的紧密组合， 从而减少不必要的计算。 此外，利用优化的并行下推自动机，本发明的实施例可以有效地分析预测无上下文的语法。 因此，除了分层处理能力和状态描述能力之外，本发明的实施例提供高效率。

公开(公告)号：US20070265291A1

公开(公告)日：2007-11-15

申请号：US11735760

申请日：2007-04-16

Applicant: Keith HARRIS ,  Bin CAO

Inventor： Keith HARRIS ,  Bin CAO

IPC: A61K31/505 ,  A61P37/08 ,  C07D239/02

CPC classification number: C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).

Abstract translation: 本发明涉及式（I）的化合物，其中Cy 1，Cy 2，L 1，L 2， R 1和R 2如本文所定义，药物组合物包含药学上有效量的一种或多种根据式（I）的化合物与药学上可接受的载体的混合物，和 治疗患有PGD2介导的病症的患者，包括但不限于过敏性疾病（例如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有系统性肥大细胞活化的病症，过敏反应 休克，支气管收缩，支气管炎，荨麻疹，湿疹，伴有瘙痒的疾病（例如特应性皮炎和荨麻疹），由于行为伴随而产生的疾病（例如白内障，视网膜脱离，炎症，感染和睡眠障碍） 痒（如刮伤 和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎等，通过向所述患者施用药学有效量的根据式（I）的化合物。

公开(公告)号：US10058620B2

公开(公告)日：2018-08-28

申请号：US14621904

申请日：2015-02-13

Applicant: Gang Cheng ,  Qiong Tang ,  Bin Cao

Inventor： Gang Cheng ,  Qiong Tang ,  Bin Cao

IPC: A61K47/48 ,  A61K48/00 ,  C12N15/87 ,  A61K47/61 ,  A61K47/64

CPC classification number: A61K47/645 ,  A61K47/61 ,  C12N15/87 ,  C12N2810/40

Abstract: One or more embodiments of the present invention provide a novel composition for gene delivery are directed to a group of polysaccharide polymers, having one or more nucleic acid delivery side chains comprising cationic peptides. In some embodiments, these cationic peptides condense and physically bond to one or more nucleic acids to form a polysaccharide-nucleic acid complex that permits delivery to and transfection of the nucleic acid(s) into cells. In some embodiments, the polysaccharide polymers of the present invention may also have one or more zwitterionic side chains and/or reactive side chains.