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公开(公告)号：US20140323953A1
公开(公告)日：2014-10-30
申请号：US13871078
申请日：2013-04-26
申请人： ALCON RESEARCH, LTD.
CPC分类号： A61M1/0047 , A61F9/00745 , A61F9/00763 , A61M1/0064 , A61M2205/3337 , A61M2210/0612
摘要： A surgical system comprises a hand piece, an irrigation conduit in fluid communication with the hand piece to carry fluid toward a surgical site, an aspiration conduit in fluid communication with the hand piece to carry fluid away from the surgical site, a pump interfacing with the aspiration conduit, the pump to create a vacuum pressure in the aspiration conduit to draw fluid through the aspiration conduit, a vacuum relief valve in fluid communication with the aspiration conduit to relieve the vacuum pressure in the aspiration conduit, a pressure sensor to detect a pressure associated with the surgical site, a controller in communication with the vacuum relief valve and the pressure sensor to control the vacuum relief valve to decrease the vacuum pressure in the aspiration conduit when the pressure detected by the pressure sensor is less than a first pressure threshold.
摘要翻译： 手术系统包括手部件，与手持件流体连通以将流体携带到外科手术部位的冲洗管道，与手持件流体连通以将流体携带离开手术部位的抽吸管道，与 抽吸导管，泵在抽吸管道中产生真空压力以将流体抽吸通过抽吸导管;真空释放阀，其与抽吸导管流体连通以减轻抽吸导管中的真空压力;压力传感器，用于检测压力 与所述手术部位相关联的控制器，与所述真空释放阀和所述压力传感器连通的控制器，以在所述压力传感器检测到的压力小于第一压力阈值时控制所述真空释放阀以降低所述抽吸管道中的真空压力。
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32.发明申请STABILIZED PHARMACEUTICAL SUB-MICRON SUSPENSIONS AND METHODS OF FORMING SAME 审中-公开稳定的药用亚微米悬浮液及其形成方法公开(公告)号：US20140294970A1
公开(公告)日：2014-10-02
申请号：US14302122
申请日：2014-06-11
申请人： Alcon Research, Ltd.
IPC分类号： A61K47/38 , A61K31/416 , A61K31/165 , A61K9/14
CPC分类号： A61K31/165 , A61K9/0048 , A61K9/10 , A61K9/14 , A61K9/1652 , A61K9/1682 , A61K31/416 , A61K47/38
摘要： The present invention is directed to a pharmaceutical submicron suspension and a method of forming the submicron suspension. The submicron suspension is useful for delivery of relatively hydrophobic and/or low solubility therapeutic agent. The submicron suspension and method of forming the submicron suspension typically employ a polymeric material that aids in preventing aggregation of the therapeutic agent.
摘要翻译： 本发明涉及药物亚微米悬浮液和形成亚微米悬浮液的方法。 亚微米悬浮液可用于递送相对疏水和/或低溶解度的治疗剂。 亚微米悬浮液和形成亚微米悬浮液的方法通常使用有助于防止治疗剂聚集的聚合物材料。
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公开(公告)号：US20140271249A1
公开(公告)日：2014-09-18
申请号：US14019224
申请日：2013-09-05
申请人： Alcon Research, Ltd.
IPC分类号： F04D25/06
CPC分类号： F04D33/00 , F04B19/006 , F04B43/043
摘要： A microfluidics acoustic pump system includes a flow passage configured to carry a fluid from one location to another, a selectively vibrating flow generator having a sharp edge, and a driving device configured to vibrate one of the flow generator and the flow passage to create a streaming fluid flow in a direction away from the sharp edge through the flow passage.
摘要翻译： 一种微流体声学泵系统，其包括被配置为将流体从一个位置运送到另一个位置的流动通道，具有尖锐边缘的选择性振动流动发生器，以及配置成使流动发生器和流动通道中的一个振动以产生流动的驱动装置 流体沿着远离尖锐边缘的方向流过流动通道。
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公开(公告)号：US20140257315A1
公开(公告)日：2014-09-11
申请号：US14162463
申请日：2014-01-23
申请人： Alcon Research, Ltd.
发明人： Yinghui Wu
IPC分类号： A61F2/16
CPC分类号： A61F2/1672 , A61F2/1667 , A61F2/167
摘要： Various systems and techniques for inserting an intraocular lens are disclosed. In particular implementations, a system and a technique for inserting an intraocular lens may include the ability to move, in response to a force being applied in a first direction along a longitudinal axis, a first plunger tip along the longitudinal axis and into a delivery cartridge to fold an intraocular lens and move in a second direction along the longitudinal axis in response to the applied force being reduced. The system and the technique may also include the ability to engage a second plunger tip and move, in response to a force being applied in the first direction along the longitudinal axis, the second plunger tip along the longitudinal axis and into the delivery cartridge to insert the intraocular lens.
摘要翻译： 公开了用于插入眼内透镜的各种系统和技术。 在特定实施方案中，用于插入眼内透镜的系统和技术可以包括响应于沿着纵向轴线沿第一方向施加的力而沿着纵向轴线移动第一柱塞末端并进入输送筒 折叠眼内透镜并且响应于所施加的力减小而沿着纵向轴线在第二方向上移动。 该系统和技术还可以包括接合第二柱塞尖端并且响应于沿着纵向轴线沿第一方向施加的力而沿着纵向轴线移动第二柱塞尖端并进入输送筒以插入的能力 眼内透镜。
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公开(公告)号：US20140172010A1
公开(公告)日：2014-06-19
申请号：US13713782
申请日：2012-12-13
申请人： ALCON RESEARCH, LTD.
发明人： Guido Vezzu
IPC分类号： A61B17/29
CPC分类号： A61B17/285 , A61B17/282 , A61B17/29 , A61B2017/00353 , A61B2017/2926 , A61B2017/305 , A61B2017/320004 , A61B2017/320008 , A61F9/00736
摘要： Membrane forceps for performing an ILM or ERM peel procedure include a handle, a tube extending from the handle, and forceps jaws extending from the tube. The forceps jaws may be configured to grasp an ILM or ERM, and may include an outer surface having a roughened surface. The roughened surface may be structurally configured to aid in gaining an edge of the ILM or ERM.
摘要翻译： 用于执行ILM或ERM剥离程序的膜钳包括手柄，从手柄延伸的管和从管延伸的钳子爪。 镊子爪可以构造成抓住ILM或ERM，并且可以包括具有粗糙表面的外表面。 粗糙表面可以在结构上构造成有助于获得ILM或ERM的边缘。
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36.发明申请Systems and Methods for Priming an Intraocular Pressure Sensor in an Intraocular Implant 有权用于在眼内植入物中引入眼内压传感器的系统和方法公开(公告)号：US20140171777A1
公开(公告)日：2014-06-19
申请号：US14094884
申请日：2013-12-03
申请人： Alcon Research, Ltd.
CPC分类号： A61B3/16 , A61B5/031 , A61F9/00781
摘要： An IOP monitoring device for implantation in an eye of a patient may include a first tube having a first opening, the first tube being configured to extend into the anterior chamber. An intraocular pressure sensing (IOP) device for implantation in an eye of a patient may include a pressure sensor, a pressure sensor cap, and a tube coupled to a chamber inlet. The pressure sensor cap may include a recess having an inner surface, the recess configured to receive the pressure sensor such that a chamber is formed by the pressure sensor and the inner surface and a chamber inlet permitting a fluid to communicate with the chamber and be primed in a bubble-free manner. The tube may be coupled to the chamber inlet to allow fluid communication between an anterior chamber of the eye and the chamber.
摘要翻译： 用于植入患者眼睛的IOP监测装置可以包括具有第一开口的第一管，所述第一管被配置为延伸到前房中。 用于植入患者眼睛的眼压检测（IOP）装置可以包括压力传感器，压力传感器盖和联接到腔室入口的管。 压力传感器盖可以包括具有内表面的凹部，凹部被配置成接收压力传感器，使得腔由压力传感器和内表面形成，并且腔室入口允许流体与腔室连通并被引燃 以无泡沫的方式。 管可以联接到腔室入口以允许眼睛的前房与腔室之间的流体连通。
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公开(公告)号：US20140161760A1
公开(公告)日：2014-06-12
申请号：US14180396
申请日：2014-02-14
申请人： Alcon Research, Ltd.
CPC分类号： A61K47/26 , A61K9/0048 , A61K31/08 , A61K31/736 , A61K47/02 , A61K47/10 , A61K47/36
摘要： The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
摘要翻译： 本发明涉及适于药物递送的人造泪液制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含干扰半乳甘露聚糖和硼酸盐的交联的顺式二醇如山梨糖醇。 任选地，制剂基本上不含二价阳离子。
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公开(公告)号：US20140135820A1
公开(公告)日：2014-05-15
申请号：US13675509
申请日：2012-11-13
申请人： ALCON RESEARCH, LTD.
发明人： Philipp Schaller , Reto Grueebler
CPC分类号： A61F9/00736 , A61B17/29 , A61B17/30 , A61B2017/00407 , A61B2017/0046 , A61B2017/00526 , A61B2017/292 , A61B2017/305 , F04C2270/0421
摘要： Example forceps, including forceps formed from a polymeric material, are disclosed herein. The forceps may include a forceps tip having a pair of grasping surfaces formed at a first end of a tip body and movable between an open position and a closed position. A tip connector is provided at a second end of the tip body for connection of the forceps tip to a handle. A sleeve is received over the tip body and is movable therealong for moving the grasping platforms between the open and closed positions.
摘要翻译： 本文公开了示例性镊子，包括由聚合物材料形成的镊子。 镊子可以包括镊子尖端，其具有形成在尖端体的第一端处并且可以在打开位置和关闭位置之间移动的一对把持表面。 尖端连接器设置在尖端体的第二端，用于将钳子尖端连接到把手。 套筒容纳在尖端主体上并且可移动，以便在打开和关闭位置之间移动抓握平台。
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公开(公告)号：US20140121469A1
公开(公告)日：2014-05-01
申请号：US14064326
申请日：2013-10-28
申请人： Alcon Research, Ltd.
CPC分类号： A61F9/00736 , A61F9/00821 , A61F2009/00863 , A61F2009/00874
摘要： A vitrector that includes an adjustable illumination aperture is described. The vitrector may include a probe and a light sleeve assembly extending along and substantially surrounding the probe. The light sleeve assembly may include a plurality of optical fibers. At least a portion of the optical fibers are operable to provide illumination so as to define an illumination aperture about the vitrectomy probe. A portion of the optical fibers may be encapsulated. The light sleeve assembly may be adjustable along a length of the probe, providing adjustment of the illumination aperture to increase or decrease an area of illumination provided thereby.
摘要翻译： 描述了包括可调节照明孔径的玻璃体。 玻璃体可以包括探针和沿着并且基本上围绕探针延伸的轻套筒组件。 灯套组件可以包括多根光纤。 光纤的至少一部分可操作以提供照明，以限定围绕玻璃体切割术探针的照明孔。 一部分光纤可以被封装。 灯套组件可以沿着探头的长度可调节，从而提供照明孔径的调节以增加或减少由此提供的照明面积。
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公开(公告)号：US20140100518A1
公开(公告)日：2014-04-10
申请号：US13648330
申请日：2012-10-10
申请人： ALCON RESEARCH, LTD.
发明人： Vincent A. Baxter , Rapheal Gordon , Gregory S. Layser , Sean Christopher Madden , Gary P. Sorensen , Daniel J. Wilson
CPC分类号： A61M3/0233 , A61M1/0058 , A61M3/0283 , A61M2205/332 , A61M2205/3331 , A61M2210/0612 , G01L5/0038 , G01L9/12
摘要： In various embodiments, a device for delivering pressurized irrigation may include a squeeze plate and a pressure sensor module. The squeeze plate may move relative to the pressure sensor module to apply pressure to a flexible container (e.g., a bag of irrigation fluid) between the squeeze plate and the pressure sensor module. The pressure sensor module may include a pressure sensor to measure a force exerted on the pressure sensor module by the flexible container as pressure is applied to the flexible container from the squeeze plate. In some embodiments, the pressure sensor module may include a bag contact plate and the pressure sensor may measure a force exerted on the bag contact plate by the flexible container located between the bag contact plate and the squeeze plate. In some embodiments, the pressure sensor may sense a pressure associated with the flexible container without an intervening bag contact plate.
摘要翻译： 在各种实施例中，用于输送加压冲洗的装置可以包括挤压板和压力传感器模块。 挤压板可以相对于压力传感器模块移动，以在挤压板和压力传感器模块之间向柔性容器（例如，一袋冲洗流体）施加压力。 压力传感器模块可以包括压力传感器，用于当压力从挤压板施加到柔性容器时，测量由柔性容器施加在压力传感器模块上的力。 在一些实施例中，压力传感器模块可以包括袋接触板，并且压力传感器可以通过位于袋接触板和挤压板之间的柔性容器来测量施加在袋接触板上的力。 在一些实施例中，压力传感器可感测与柔性容器相关联的压力，而没有中间袋接触板。
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