公开(公告)号：US20150247165A1

公开(公告)日：2015-09-03

申请号：US14479803

申请日：2014-09-08

Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM

Inventor： Harald zur HAUSEN ,  Ethel-Michele de VILLIERS

IPC: C12N15/86 ,  C12N7/00

CPC classification number: C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/00021 ,  C12N2750/00022 ,  C12N2750/00034 ,  C12N2750/00043 ,  C12Q1/701

Abstract: Described are single-stranded new sequences of TT viruses, rearranged TTV sequences and hybrid molecules of a specific TT virus sequence and host cell DNA that are capable of replicating autonomously for use in diagnosis, prevention and treatment of diseases like cancer and autoimmunity. In addition, it relates to the use of such molecules as gene vectors and artificial chromosomes.

Abstract translation: 描述了TT病毒的单链新序列，重排的TTV序列和特异性TT病毒序列的混合分子以及能够自主复制用于诊断，预防和治疗诸如癌症和自身免疫的疾病的宿主细胞DNA。 此外，它涉及使用这样的分子作为基因载体和人造染色体。

公开(公告)号：US09107859B2

公开(公告)日：2015-08-18

申请号：US12878630

申请日：2010-09-09

Applicant: Noel Joseph Francois Detraz ,  Guillaume Rigaut

Inventor： Noel Joseph Francois Detraz ,  Guillaume Rigaut

IPC: A61K39/12 ,  A61K39/00 ,  A61K39/02 ,  A61P37/00 ,  A61K39/135 ,  A61K39/39 ,  A61K39/125

CPC classification number: A61K39/00 ,  A61K9/0019 ,  A61K9/107 ,  A61K39/0241 ,  A61K39/12 ,  A61K39/125 ,  A61K39/135 ,  A61K39/39 ,  A61K45/06 ,  A61K47/06 ,  A61K47/26 ,  A61K2039/52 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/55577 ,  C12N7/00 ,  C12N2750/00022 ,  C12N2750/00034 ,  C12N2750/10034 ,  C12N2770/32022 ,  C12N2770/32134

Abstract: The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.

Abstract translation: 本发明提供一种新型的水包油（O / W）乳液，其在细菌或病毒悬浮液，特别是浓缩和非纯化（粗提取物）或最低限纯化的存在下具有增加的稳定性。 本发明的乳液可用作递送包含至少一种免疫原的药物组合物，特别是选自灭活病原体，减毒病原体，亚单位，重组表达载体的免疫原的载体 ，以及质粒或其组合。

公开(公告)号：US20140286980A1

公开(公告)日：2014-09-25

申请号：US14122423

申请日：2012-05-24

Applicant: Jacqueline Gayle Marx

Inventor： Jacqueline Gayle Marx

IPC: C12N7/00

CPC classification number: C12N7/00 ,  A61K35/13 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N7/02 ,  C12N15/86 ,  C12N2750/00021 ,  C12N2750/00034

Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length TTV genomes that can replicate efficiently in host animals and tissue culture.

Abstract translation: 本发明涉及扭矩腱病毒（“TTV”）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。 根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。 诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。 本发明的特别重要的方面包括在组织培养和宿主猪中复制的多核苷酸构建体。 本发明还提供了可以在宿主动物和组织培养中有效复制的新型全长TTV基因组。

公开(公告)号：US20120321654A1

公开(公告)日：2012-12-20

申请号：US13501371

申请日：2010-04-16

Applicant: Gregory Paul Nitzel ,  Robert Gerard Ankenbauer ,  Jay Gregory Calvert ,  Donna Steuerwald Dunyak ,  Jacqueline Gayle Marx ,  Nancee Lois Oien ,  Douglas Steven Pearce ,  Mira Ivanova Stoeva ,  James Richard Thompson

Inventor： Gregory Paul Nitzel ,  Robert Gerard Ankenbauer ,  Jay Gregory Calvert ,  Donna Steuerwald Dunyak ,  Jacqueline Gayle Marx ,  Nancee Lois Oien ,  Douglas Steven Pearce ,  Mira Ivanova Stoeva ,  James Richard Thompson

IPC: A61K39/12 ,  C12N15/63 ,  C12N1/21 ,  C07K16/08 ,  C12N5/10 ,  C12N7/01 ,  C12N7/04 ,  C07K14/01 ,  C12N15/34 ,  C12N1/19

CPC classification number: A61K39/12 ,  A61K2039/552 ,  C07K14/005 ,  C07K16/081 ,  C07K2317/33 ,  C12N7/00 ,  C12N2750/00021 ,  C12N2750/00022 ,  C12N2750/00034 ,  C12N2750/10021 ,  C12N2750/10034

Abstract: The present invention is directed to novel nucleotide and amino acid sequences of Torque teno virus (“TTV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine TTV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include vaccines that provide TTV ORF1 protein, or peptide fragments thereof, as antigen.

Abstract translation: 本发明涉及扭矩腱病毒（TTV）的新型核苷酸和氨基酸序列，其包括其新型基因型，所有这些都可用于制备用于治疗和预防猪和其他动物疾病的疫苗。 根据本发明的实践提供的疫苗对多种猪TTV基因型和分离株有效。 诊断和治疗性多克隆和单克隆抗体也是本发明的特征，以及用于病毒繁殖和疫苗制备中的感染性克隆也是如此。 本发明的特别重要的方面包括提供TTV ORF1蛋白或其肽片段作为抗原的疫苗。