公开(公告)号：US20150247165A1

公开(公告)日：2015-09-03

申请号：US14479803

申请日：2014-09-08

Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM

Inventor： Harald zur HAUSEN ,  Ethel-Michele de VILLIERS

IPC: C12N15/86 ,  C12N7/00

CPC classification number: C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/00021 ,  C12N2750/00022 ,  C12N2750/00034 ,  C12N2750/00043 ,  C12Q1/701

Abstract: Described are single-stranded new sequences of TT viruses, rearranged TTV sequences and hybrid molecules of a specific TT virus sequence and host cell DNA that are capable of replicating autonomously for use in diagnosis, prevention and treatment of diseases like cancer and autoimmunity. In addition, it relates to the use of such molecules as gene vectors and artificial chromosomes.

Abstract translation: 描述了TT病毒的单链新序列，重排的TTV序列和特异性TT病毒序列的混合分子以及能够自主复制用于诊断，预防和治疗诸如癌症和自身免疫的疾病的宿主细胞DNA。 此外，它涉及使用这样的分子作为基因载体和人造染色体。