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39 条记录 (耗时 0.044 秒)

    Analgetic and antiemetic compositions
    26.
    发明授权
    Analgetic and antiemetic compositions 失效
    止痛药和止吐药

    公开(公告)号：US4707559A

    公开(公告)日：1987-11-17

    申请号：US870154

    申请日：1986-06-03

    申请人： Raphael Mechoulam ,  Jeffery J. Feigenbaum

    发明人： Raphael Mechoulam ,  Jeffery J. Feigenbaum

    IPC分类号： C07C43/23 ,  C07C43/21 ,  A61K31/085

    CPC分类号： C07C43/23

    摘要： There are provided 3-(6-alkoxy-4-alkyl-2-hydroxyphenyl) cyclohexanol derivatives and pharmaceutical compositions containing these as active ingredient. These are useful as potent analgesics and also as antiemetics. The compounds have the advantage of being devoid of psychotropic activity.

    摘要翻译： 提供3-（6-烷氧基-4-烷基-2-羟基苯基）环己醇衍生物和含有它们作为活性成分的药物组合物。 这些作为强效止痛剂以及止吐剂都是有用的。 这些化合物具有缺乏精神活性的优点。

    Silicon-containing beta-phenylethylamines and intermediates for their preparation
    27.
    发明授权
    Silicon-containing beta-phenylethylamines and intermediates for their preparation 失效
    含硅含量的苯乙烯胺及其制备中间体

    公开(公告)号：US3505376A

    公开(公告)日：1970-04-07

    申请号：US3505376D

    申请日：1965-10-22

    申请人： YISSUM RES DEV CO

    发明人： FRANKEL MAX ,  GERTNER DAVID ,  BROZE MORDECHAI ,  HANNA PARDESS ,  ZILKHA ALBERT

    IPC分类号： C07F7/08 ,  C07F7/10

    CPC分类号： C07F7/0818

    摘要： Novel trialkylsilyl-b -phenylethylamine compounds having the formula wherein R1, R2 and R3 are alkyl, R4 is hydrogen, hydroxyl or alkyl, R5 is hydrogen, hydroxymethyl, carboxyl or alkyl, R6 and R7 are hydrogen or alkyl and when R6 is hydrogen then R7 may also be acyl or haloacyl, are prepared from intermediates of formula where n is 0 or 1, X is chlorine, carboxyl, nitrile or hydroxyl and R8 is hydrogen, alkyl or acyl. In examples preparations described are of b - (trimethylsilylphenyl)ethylamine from trimethylsilylbenzyl cyanide and lithium aluminium hydride; b -(trimethylsilylphenyl)ethyldimethylamine from b -(trimethylsilylphenyl)-ethyl chloride and dimethylamine; b -(trimethylsilylphenyl)-propylamine from a -(trimethylsilylphenyl)propionitrile and lithium aluminium hydride; 1-(trimethylsilylphenyl)-2-aminopropane by reacting trimethylsilylbenzyl cyanide with magnesium, then with methylcyanide and reducing with lithium aluminium hydride; b -(trimethylsilylphenyl) -serine from trimethylsilylbenzaldehyde and glycine; 1-(trimethylsilylphenyl)-2-aminopropane-1,3-diol from b -(trimethylsilylphenyl)serine and lithium aluminium hydride; 1 - (trimethylsilylphenyl) - 2 - dichloroacetamido propane-1,3-diol from the -2-aminopropane-1,3-diol and methyl dichloracetate. Intermediates, other than those used as starting materials above, which are prepared are trimethylsilylphenyl acetic acid, b -(trimethylsilylphenyl) ethyl alcohol, trimethylsilylbenzyl chloride and 1-cyano-1-(trimethylsilyl)-phenyl acetone. The methods of preparing the intermediates are described.