公开(公告)号：US09382531B2

公开(公告)日：2016-07-05

申请号：US14058959

申请日：2013-10-21

Applicant: Wisconsin Alumni Research Foundation

Inventor： Igor Slukvin ,  Irina Elcheva

IPC: C12N5/00 ,  C12N15/00 ,  C12N5/0789 ,  C12N15/11 ,  C12N15/66

CPC classification number: C12N5/0606 ,  C12N5/0608 ,  C12N5/0647 ,  C12N15/00 ,  C12N15/11 ,  C12N15/66 ,  C12N2501/60 ,  C12N2501/998 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2740/16043

Abstract: Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hPSCs of a combination of transcription factors as described herein.

Abstract translation: 本文描述的是通过在本文所述的转录因子的组合的hPSC中强制表达，诱导人多能干细胞（hPSC）分化为具有泛骨髓潜能或限制性潜力的血细胞内皮的方法和相关组合物。

公开(公告)号：US20140369968A1

公开(公告)日：2014-12-18

申请号：US14303428

申请日：2014-06-12

Applicant: Wisconsin Alumni Research Foundation

Inventor： Igor Slukvin ,  Akhilesh Kumar

IPC: C12N5/077 ,  A61K35/34

CPC classification number: C12N5/0661 ,  A61K35/28 ,  A61K35/34 ,  A61K35/44 ,  C12N2500/90 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/165 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/1346 ,  C12N2506/45

Abstract: The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention provides methods for generating substantially pure populations of vasculogenic cells from human mesenchymal progenitors, and methods and compositions for clinical applications in the field of regenerative medicine.

Abstract translation: 本发明一般涉及用于治疗性血管组织工程的方法和组合物。 特别地，本发明提供从人间充质祖细胞产生基本上纯的血管生成细胞群的方法，以及用于再生医学领域临床应用的方法和组合物。

公开(公告)号：US20140234971A1

公开(公告)日：2014-08-21

申请号：US14058959

申请日：2013-10-21

Applicant: Wisconsin Alumni Research Foundation

Inventor： Igor Slukvin ,  Irina Elcheva

IPC: C12N15/86 ,  C12N5/0789

CPC classification number: C12N5/0606 ,  C12N5/0608 ,  C12N5/0647 ,  C12N15/00 ,  C12N15/11 ,  C12N15/66 ,  C12N2501/60 ,  C12N2501/998 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2510/00 ,  C12N2740/16043

Abstract: Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hPSCs of a combination of transcription factors as described herein.

Abstract translation: 本文描述的是通过在本文所述的转录因子组合的hPSC中强制表达，诱导将人多能干细胞（hPSC）分化为具有泛骨髓潜能或限制性潜力的血细胞内皮的方法和相关组合物。