公开(公告)号：US20100004209A1

公开(公告)日：2010-01-07

申请号：US12447369

申请日：2007-10-04

Applicant: Christophe Carola ,  Herwig Buchholz

Inventor： Christophe Carola ,  Herwig Buchholz

IPC: A61K31/665 ,  C07F9/06

CPC classification number: C07F9/65522 ,  A23D7/0053 ,  A23K20/105 ,  A23K20/121 ,  A23L33/10 ,  A61K8/498 ,  A61K8/55 ,  A61K2800/522 ,  A61K2800/782 ,  A61Q17/00 ,  A61Q19/08 ,  C11B5/0021

Abstract: The present invention relates to compounds of the formula (I), where R1 to each, independently of one another, denote H, hydroxyl or alkoxy having 1 to 8 C atoms, R4 denotes alkyl having 1 to 4 C atoms, H, hydroxyl or alkoxy having 1 to 8 C atoms, R5 denotes H or hydroxyl, and R6 denotes H or alkyl having 1 to 18 C atoms, or salts thereof, but where all R1 to R4 together cannot be equal to H, to compositions, and to the preparation and use thereof.

Abstract translation: 本发明涉及式（I）化合物，其中R 1各自独立地表示H，羟基或具有1至8个C原子的烷氧基，R 4表示具有1至4个C原子的烷基，H，羟基或 具有1至8个C原子的烷氧基，R 5表示H或羟基，R 6表示H或具有1至18个C原子的烷基或其盐，但其中所有R 1至R 4不能等于H， 制备和使用。

公开(公告)号：US07588783B2

公开(公告)日：2009-09-15

申请号：US10581494

申请日：2004-11-05

Applicant: Herwig Buchholz ,  Corinna Wirth ,  Christophe Carola ,  Rosane Alves Fontes

Inventor： Herwig Buchholz ,  Corinna Wirth ,  Christophe Carola ,  Rosane Alves Fontes

IPC: A61K36/00

CPC classification number: A61Q19/00 ,  A61K8/498 ,  C07D311/30

Abstract: The invention relates to a novel flavonoid derivative, to an extract comprising the flavonoid derivative, to the cosmetic and pharmaceutical use thereof, to preparations comprising the flavonoid derivative or extract, and to a process for the preparation of the flavonoid derivative or extract.

Abstract translation: 本发明涉及一种新颖的类黄酮衍生物，涉及包含类黄酮衍生物的提取物，其化妆品和药物用途，包括类黄酮衍生物或提取物的制剂，以及用于制备类黄酮衍生物或提取物的方法。

公开(公告)号：US20090220438A1

公开(公告)日：2009-09-03

申请号：US12162527

申请日：2007-01-09

Applicant: Christophe Carola ,  Anne Toullec ,  Herwig Buchholz

Inventor： Christophe Carola ,  Anne Toullec ,  Herwig Buchholz

IPC: A61K8/49 ,  C07D311/04 ,  A61Q17/04

CPC classification number: C07D311/22 ,  A61K8/498 ,  A61Q19/04

Abstract: The invention relates to the use of compounds of the formula (I), where R1 and R2 may be identical or different and stand for H, OH, OCH3, CH3, CH2OH or CH2OCH3, R3 stands for H or straight-chain or branched C1- to C20-alkyl groups, R4 stands for H or OR8, R5 and R6 may be identical or different and are selected from —H, —OH, straight-chain or branched C1 to C20-alkyl groups, straight-chain or branched C3- to C20-alkenyl groups, straight-chain or branched C1- to C20-hydroxyalkyl groups, where the hydroxyl group may be bonded to a primary or secondary carbon atom of the chain, and furthermore the allyl chain may also be interrupted by oxygen, and R8 stands for H or straight-chain or branched C1- to C20-alkyl groups, with the proviso that R2 does not denote H if R1 denotes CH3, as self-tanning agents, and to compounds and the preparation thereof.

Abstract translation: 本发明涉及式（I）化合物的用途，其中R1和R2可以相同或不同，代表H，OH，OCH3，CH3，CH2OH或CH2OCH3，R3代表H或直链或支链C1 - 至C20烷基，R4代表H或OR8，R5和R6可以相同或不同，选自-H，-OH，直链或支链C1至C20-烷基，直链或支链C3 - 至20个烯基，直链或支链的C 1 -C 20羟基烷基，其中羟基可以键合到链的伯或仲碳原子上，此外，烯丙基链也可以被氧中断， 并且R 8代表H或直链或支链C 1至C 20烷基，条件是如果R 1表示CH 3，R 2不表示H，作为自鞣剂，以及化合物及其制备。

公开(公告)号：US20080112905A1

公开(公告)日：2008-05-15

申请号：US11791544

申请日：2005-11-03

Applicant: Christophe Carola ,  Anne Toullec ,  Herwig Buchholz

Inventor： Christophe Carola ,  Anne Toullec ,  Herwig Buchholz

IPC: A61K8/73 ,  A61Q17/04

CPC classification number: A61K8/498 ,  A61K8/04 ,  A61K8/046 ,  A61K8/602 ,  A61K8/738 ,  A61K2800/56 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  C07D311/30

Abstract: The invention relates to complexes of certain flavonoid derivatives, of the formula (1), where R1 and R2 are selected from H and OR11, where OR11 stands, independently of one another, for OH, straight-chain or branched C1- to C20-alkoxy groups, straight-chain or branched C3- to C20-alkenyloxy groups, straight-chain or branched C1- to C20-hydroxyalkoxy groups, where the hydroxyl group(s) may be bonded to a primary or secondary carbon atom in the chain and furthermore the alkyl chain may also be interrupted by oxygen, and/or C3- to C10-cycloalkoxy groups and/or C3- to C12-cycloalkenyloxy groups, where the rings may in each case also be bridged by —(CH2)n— groups, where n=1 to 3, and/or mono- and/or oligoglycosyl radicals, with the proviso that at least one radical from R1 and R2 stands for OR11, and R3 to R10 may be identical or different and stand, independently of one another, for radicals which are substantially inert with respect to the UV properties, to compositions which comprise such complexes, to corresponding processes for the preparation of the complexes or the compositions comprising the latter, and to the use thereof, in particular for the care, preservation or improvement of the general condition of the skin or hair and for light protection.

Abstract translation: 本发明涉及式（1）的某些类黄酮衍生物的复合物，其中R 1和R 2选自H和OR 11 >，其中OR 11彼此独立地表示OH，直链或支链C 1至C 20 - 烷氧基 直链或支链C 3 - 至C 20 - 炔基氧基，直链或支链C 1至C 1 - 20个羟基烷氧基，其中羟基可以键合到链中的伯或仲碳原子上，此外烷基链也可以被氧中断，和/或C 3 < C 12 - 环烷氧基和/或C 3 - 至C 12 - 环烯氧基，其中环可以在每个 情况也可以通过其中n = 1-3的基团和/或单糖基和/或寡糖基自由基桥连，条件是 R 1和R 2中的至少一个基团代表OR SUP> 11和R 3至R 10可以相同或不同，彼此独立地表示相对于基本上为惰性的基团 UV性质，包含这种复合物的组合物，用于制备复合物或包含其的组合物的相应方法及其用途，特别是用于护理，保存或改善皮肤的一般状况或 头发和保护光。

公开(公告)号：US20080044364A1

公开(公告)日：2008-02-21

申请号：US11791542

申请日：2005-11-04

Applicant: Christophe Carola ,  Anne Toullec ,  Herwig Buchholz

Inventor： Christophe Carola ,  Anne Toullec ,  Herwig Buchholz

IPC: A61K31/724 ,  A23L1/00 ,  A61K8/30 ,  A61Q17/04 ,  C08B37/16 ,  A61P17/18 ,  A23L1/30

CPC classification number: A61Q19/08 ,  A61K8/498 ,  A61K8/738 ,  A61K2800/522 ,  A61K2800/56 ,  A61Q17/04 ,  A61Q19/00 ,  C07D311/30 ,  C08B37/0015 ,  C08L5/16

Abstract: The invention relates to compounds of the formula I where R1 to R10 may be identical or different and are selected from H, OR11, straight-chain or branched C1- to C20-alkyl groups or hydroxyalkyl groups, straight-chain or branched C3- to C20-alkenyl groups and/or C3- to C12-cycloalkenyl groups, where the rings may each also be bridged by —(CH2)n— groups, where n=1 to 3, where all OR11, independently of one another, stand for OH, C1- to C20-alkoxy groups, C3- to C20-alkenyloxy groups, straight-chain or branched C1- to C20-hydroxyalkoxy groups and/or C3- to C10-cycloalkoxy groups and/or C3- to C12-cycloalkenyloxy groups, where the rings may each also be bridged by —(CH2)n— groups, where n=1 to 3, and/or mono- and/or oligoglycosyl radicals, CD stands for a cyclodextrin molecule, o stands for the number 1 and p stands for a number from the range 0.5 to 50, with the proviso that at least 2 radicals from R1 to R7 stand for OH and that at least 1 pair of adjacent —OH groups is present in the molecule.

Abstract translation: 本发明涉及式I化合物，其中R 1至R 10可以相同或不同，并且选自H，OR 11， 直链或支链的C 1至C 20 - 烷基或羟烷基，直链或支链C 3 - 亚烷基和/或C 3 - 至C 12 - 环烯基，其中各环也可以被 - （CH 3） 其中n = 1至3，其中全部OR 11彼此独立地代表OH，C _{7 代表OH并且分子中存在至少1对相邻的-OH基团。}

公开(公告)号：US20080027133A1

公开(公告)日：2008-01-31

申请号：US11869192

申请日：2007-10-09

Applicant: Christophe Carola ,  Herwig Buchholz ,  Sylvia Huber ,  Ralf Rosskopf

Inventor： Christophe Carola ,  Herwig Buchholz ,  Sylvia Huber ,  Ralf Rosskopf

IPC: A61K31/35 ,  A61P17/00

CPC classification number: A61K8/498 ,  A23L33/10 ,  A61K31/05 ,  A61K31/122 ,  A61K31/35 ,  A61K31/352 ,  A61K45/06 ,  A61K2800/782 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  A61K2300/00

Abstract: The invention relates to the use of chromen-4-one derivatives of the formula I where R1 and R2 may be identical or different and are selected from H, —C(═O)—R7, —C(═O)—OR7, alkyl groups, alkenyl groups, hydroxyalkyl groups and/or cycloalkyl groups and/or cycloalkenyl groups, R3 is H or alkyl groups, R4 is H or OR8, R5 and R6 are selected from —H, —OH, alkyl groups, alkenyl groups and hydroxyalkyl groups, and R7 is H, alkyl groups, a polyhydroxyl compound, such as, preferably, an ascorbic acid radical or glycosidic radicals, and R8 is H or alkyl groups, where at least two of the substituents R1, R2 and R4-R6 are different from H or at least one substituent from R1 and R2 is —C(═O)—R7 or —C(═O)—OR7, for the care, preservation or improvement of the general state of the skin or hair.

Abstract translation: 本发明涉及使用式I的色烯-4-酮衍生物，其中R 1和R 2可以相同或不同，并且选自H，-C （-O）-R 7，-C（-O）-OR 7，烷基，烯基，羟烷基和/或环烷基和/或环烯基 R 3是H或烷基，R 4是H或OR 8，R 5和R 5， SUP> 6选自-H，-OH，烷基，烯基和羟烷基，R 7是H，烷基，多羟基化合物，例如优选的是， 抗坏血酸基团或糖苷基，R 8是H或烷基，其中至少两个取代基R 1，R 2， R 4和R 4不同于H或至少一个R 1和R 2的取代基是 -C（-O）-R 7或-C（-O）-OR 7，用于护理，保存或改善皮肤或毛发的一般状态 。

公开(公告)号：US20070134172A1

公开(公告)日：2007-06-14

申请号：US10581494

申请日：2004-11-05

Applicant: Herwig Buchholz ,  Corinna Wirth ,  Christophe Carola ,  Rosane Alves Fontes

Inventor： Herwig Buchholz ,  Corinna Wirth ,  Christophe Carola ,  Rosane Alves Fontes

IPC: A61K31/366 ,  A61K36/185 ,  A61K8/49

CPC classification number: A61Q19/00 ,  A61K8/498 ,  C07D311/30

Abstract: The invention relates to a novel flavonoid derivative, to an extract comprising the flavonoid derivative, to the cosmetic and pharmaceutical use thereof, to preparations comprising the flavonoid derivative or extract, and to a process for the preparation of the flavonoid derivative or extract.

Abstract translation: 本发明涉及一种新颖的类黄酮衍生物，涉及包含类黄酮衍生物的提取物，其化妆品和药物用途，包括类黄酮衍生物或提取物的制剂，以及用于制备类黄酮衍生物或提取物的方法。

公开(公告)号：US6096724A

公开(公告)日：2000-08-01

申请号：US88740

申请日：1998-06-02

Applicant: Thomas Brian Hamilton McMurry ,  Robert Stanley McElhinney ,  Joan Elizabeth McCormick ,  Dorothy Josephine Donnelly ,  Paul Murray ,  Christophe Carola ,  Rhoderick Hugh Elder ,  Jane Kelly ,  Geoffrey Paul Margison ,  Amanda Jean Watson ,  Joseph Anthony Rafferty ,  Mark Andrew Willington ,  Mark Ross Middleton

Inventor： Thomas Brian Hamilton McMurry ,  Robert Stanley McElhinney ,  Joan Elizabeth McCormick ,  Dorothy Josephine Donnelly ,  Paul Murray ,  Christophe Carola ,  Rhoderick Hugh Elder ,  Jane Kelly ,  Geoffrey Paul Margison ,  Amanda Jean Watson ,  Joseph Anthony Rafferty ,  Mark Andrew Willington ,  Mark Ross Middleton

IPC: C07D239/47 ,  A61K31/00 ,  A61K31/17 ,  A61K31/505 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522 ,  A61K31/529 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K31/708 ,  A61P35/00 ,  A61P43/00 ,  C07D239/46 ,  C07D239/48 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D473/00 ,  C07D473/18 ,  C07D473/22 ,  C07D473/30 ,  C07D473/40 ,  C07D475/02 ,  C07D475/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07H19/04 ,  C07H19/06 ,  C07H19/16 ,  C07H19/167 ,  C07H19/173 ,  C07H19/19 ,  C07H19/23 ,  A01N43/04 ,  C07H19/00

CPC classification number: C07D239/47 ,  C07D471/04 ,  C07D473/00 ,  C07D473/18 ,  C07D473/22 ,  C07D473/30 ,  C07D473/40 ,  C07D475/04 ,  C07D487/04 ,  C07H19/04

Abstract: The present invention provides certain 6-hetarylalkyloxy pyrimidine derivatives of formula II ##STR1## wherein R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hetero atom chosen from O, N, or S, or a substituted derivative thereof; or (ii) phenyl or a substituted derivative thereof,R.sup.2 is selected from H, C.sub.1 -C.sub.5 alkyl, halogen or NH.sub.2,R.sup.4 and R.sup.5 which are the same or different are selected from H, NH.sub.2 or NO.sub.n where n=1 or 2, or R.sup.4 and R.sup.5 together with the pyrimidine ring form a 5- or 6-membered ring structure containing one or more heterocyclic atoms, and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O.sup.6 -alkylguanine-DNA alkyltransferase (ATase) activity.

Abstract translation: 本发明提供了一些式II的6-芳基烷氧基嘧啶衍生物，其中R是（i）具有至少一个5-或6-元杂环的环状基团，任选地与其中稠合的碳环或杂环，该杂环或每个杂环 具有至少一个选自O，N或S的杂原子或其取代的衍生物; 或（ii）苯基或其取代衍生物，R2选自H，C1-C5烷基，卤素或NH2，R4和R5相同或不同，选自H，NH2或NON，其中n = 1或2， 或R4和R5与嘧啶环一起形成含有一个或多个杂环原子的5-或6-元环结构及其药学上可接受的盐，表现出消耗O6-烷基鸟嘌呤-DNA烷基转移酶（ATase）活性的能力。

公开(公告)号：US09499508B2

公开(公告)日：2016-11-22

申请号：US13991915

申请日：2011-11-14

Applicant: Christophe Carola ,  Tatjana Mueller

Inventor： Christophe Carola ,  Tatjana Mueller

IPC: C07D309/36 ,  A61K8/49 ,  A61Q19/06 ,  A61Q19/08 ,  C07D309/38 ,  A23L1/03

CPC classification number: A61K8/498 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/062 ,  A61K2800/522 ,  A61Q17/04 ,  A61Q19/06 ,  A61Q19/08 ,  C07D309/36 ,  C07D309/38

Abstract: The present invention relates to the use of compounds of the formula (I) for the care, preservation or improvement of the general condition or appearance of the skin or hair, and to preparations comprising compounds of the formula (I).

Abstract translation: 本发明涉及式（I）化合物用于护理，保存或改善皮肤或毛发的一般状况或外观以及包含式（I）化合物的制剂的用途。

公开(公告)号：US09044409B2

公开(公告)日：2015-06-02

申请号：US11869192

申请日：2007-10-09

Applicant: Christophe Carola ,  Herwig Buchholz ,  Sylvia Huber ,  Ralf Rosskopf

Inventor： Christophe Carola ,  Herwig Buchholz ,  Sylvia Huber ,  Ralf Rosskopf

IPC: A61K31/05 ,  A61K31/122 ,  A61K31/35 ,  A61K31/352 ,  A61K8/49 ,  A23L1/30 ,  A61K45/06 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q11/00 ,  A61Q19/02

CPC classification number: A61K8/498 ,  A23L33/10 ,  A61K31/05 ,  A61K31/122 ,  A61K31/35 ,  A61K31/352 ,  A61K45/06 ,  A61K2800/782 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  A61K2300/00

Abstract: The invention relates to the use of chromen-4-one derivatives of the formula I where R1 and R2 may be identical or different and are selected from H, —C(═O)—R7, —C(═O)—OR7, alkyl groups, alkenyl groups, hydroxyalkyl groups and/or cycloalkyl groups and/or cycloalkenyl groups, R3 is H or alkyl groups, R4 is H or OR8, R5 and R6 are selected from —H, —OH, alkyl groups, alkenyl groups and hydroxyalkyl groups, and R7 is H, alkyl groups, a polyhydroxyl compound, such as, preferably, an ascorbic acid radical or glycosidic radicals, and R8 is H or alkyl groups, where at least two of the substituents R1, R2 and R4-R6 are different from H or at least one substituent from R1 and R2 is —C(═O)—R7 or —C(═O)—OR7, for the care, preservation or improvement of the general state of the skin or hair.

Abstract translation: 本发明涉及式I的色烯-4-酮衍生物的用途，其中R 1和R 2可以相同或不同，并且选自H，-C（= O）-R 7，-C（= O）-OR 7， 烷基，烯基，羟基烷基和/或环烷基和/或环烯基，R3是H或烷基，R4是H或OR8，R5和R6选自-H，-OH，烷基，烯基和 羟基烷基，R7是H，烷基，多羟基化合物，例如优选抗坏血酸基团或糖苷基，R8是H或烷基，其中至少两个取代基R 1，R 2和R 4 -R 6 不同于H或R1的至少一个取代基，R2是-C（= O）-R7或-C（= O）-OR7），用于护理，保存或改善皮肤或头发的一般状态。