公开(公告)号：US20220306761A1

公开(公告)日：2022-09-29

申请号：US17664609

申请日：2022-05-23

Applicant: Hoffmann-La Roche Inc.

Inventor： Harald DUERR ,  Sebastian FENN ,  Ulrich GOEPFERT ,  Sabine IMHOF-JUNG ,  Christian KLEIN ,  Laurent LARIVIERE ,  Michael MOLHOJ ,  Joerg Thomas REGULA ,  Petra RUEGER ,  Wolfgang SCHAEFER

IPC: C07K16/28 ,  A61P25/00

Abstract: Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.

公开(公告)号：US20200369758A1

公开(公告)日：2020-11-26

申请号：US16843763

申请日：2020-04-08

Applicant: Hoffmann-La Roche Inc.

Inventor： Sabine IMHOF-JUNG ,  Christian KLEIN ,  Joerg Thomas REGULA ,  Wolfgang SCHAEFER ,  Juergen Michael SCHANZER

IPC: C07K16/22 ,  C07K16/46

Abstract: The present invention relates to bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

公开(公告)号：US20200231673A1

公开(公告)日：2020-07-23

申请号：US16799662

申请日：2020-02-24

Applicant: Hoffmann-La Roche Inc.

Inventor： Oliver AST ,  Marina BACAC ,  Sabine IMHOF-JUNG ,  Christiane NEUMANN ,  Christian KLEIN ,  Stefan KLOSTERMANN ,  Michael MOLHOJ ,  Joerg Thomas REGULA ,  Wolfgang SCHAEFER ,  Pablo UMANA

IPC: C07K16/28 ,  C07K16/32 ,  C07K16/30

Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

公开(公告)号：US20200216554A1

公开(公告)日：2020-07-09

申请号：US16822972

申请日：2020-03-18

Applicant: Hoffmann-La Roche Inc.

Inventor： Harald DUERR ,  Sebastian FENN ,  Ulrich GOEPFERT ,  Sabine IMHOF-JUNG ,  Christian KLEIN ,  Laurent LARIVIERE ,  Michael MOLHOJ ,  Joerg Thomas REGULA ,  Petra RUEGER ,  Wolfgang SCHAEFER

IPC: C07K16/28 ,  A61P25/00

Abstract: Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.

公开(公告)号：US20180312573A1

公开(公告)日：2018-11-01

申请号：US15961699

申请日：2018-04-24

Applicant: Hoffmann-La Roche Inc.

Inventor： Birgit BOSSENMAIER ,  Hubert KETTENBERGER ,  Christian KLEIN ,  Klaus-Peter KUENKELE ,  Joerg-Thomas REGULA ,  Wolfgang SCHAEFER ,  Manfred SCHWAIGER ,  Claudio SUSTMANN

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/32

Abstract: The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof.

公开(公告)号：US20180222980A1

公开(公告)日：2018-08-09

申请号：US15879040

申请日：2018-01-24

Applicant: Hoffmann-La Roche Inc.

Inventor： Oliver AST ,  Marina BACAC ,  Sabine IMHOF-JUNG ,  Christiane JAEGER ,  Christian KLEIN ,  Stefan KLOSTERMANN ,  Michael MOLHOJ ,  Joerg Thomas REGULA ,  Wolfgang SCHAEFER ,  Pablo UMANA

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/32

CPC classification number: C07K16/2809 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/3053 ,  C07K16/32 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/526 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/64 ,  C07K2317/66 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

公开(公告)号：US20180079805A1

公开(公告)日：2018-03-22

申请号：US15495641

申请日：2017-04-24

Applicant: HOFFMANN-LA ROCHE INC.

Inventor： Sabine IMHOF-JUNG ,  Christian KLEIN ,  Joerg Thomas REGULA ,  Wolfgang SCHAEFER ,  Juergen Michael SCHANZER

IPC: C07K16/22 ,  C07K16/46

CPC classification number: C07K16/22 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/64 ,  C07K2317/66 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00

Abstract: The present invention relates to bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.