公开(公告)号：US20200094079A1

公开(公告)日：2020-03-26

申请号：US16143255

申请日：2018-09-26

Applicant: General Electric Company

Inventor： Christopher Michael Puleo ,  Lakshmi Sireesha Kaanumalle ,  Victoria Eugenia Cotero ,  John Frederick Graf

IPC: A61N7/00 ,  A61N1/36 ,  G01N33/68

Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.

公开(公告)号：US20170091527A1

公开(公告)日：2017-03-30

申请号：US14871667

申请日：2015-09-30

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Brion Daryl Sarachan ,  John Frederick Graf ,  Vidya Pundalik Kamath

IPC: G06K9/00 ,  G06K9/32 ,  G06K9/62

CPC classification number: G06K9/00147 ,  G06K9/00134 ,  G06K9/0014 ,  G06K9/3241 ,  G06K9/6215 ,  G06K9/6219 ,  G06K9/6224 ,  G06K9/6247

Abstract: The present disclosure relates to characterization of biological samples. By way of example, a biological sample may be contacted with a plurality of probes specific for targets in the sample, such as probes for immune markers and segmenting probes. Acquired image data of the sample may be used to segment the images into epithelial and stromal regions to characterize individual cells in the sample based on the binding of the probes. Further, the biological sample may be characterized by a heterogeneity of the characterized cells.

公开(公告)号：US20160358326A1

公开(公告)日：2016-12-08

申请号：US14729982

申请日：2015-06-03

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Brion Daryl Sarachan ,  John Frederick Graf ,  Anup Sood ,  Vidya Pundalik Kamath

IPC: G06T7/00 ,  G06F17/30 ,  G06F19/00

CPC classification number: G06F17/30259 ,  G06F19/00 ,  G06F19/321

Abstract: Dynamic linking of pathway maps and cell maps is disclosed in certain embodiments. In such embodiments, the pathway maps are linked to spatially-localized regional nucleic acid data (e.g., sequence data), as opposed to non-spatially selected nucleic acid data. The pathway map and cell map data may be linked so that interactions results in changes or updates to the linked map, such as the selection or highlighting of cells exhibiting pathway map characteristics specified by a user of updating of node values or states to correspond to that of a cell or cells selected by the user.

Abstract translation: 在某些实施方案中公开了途径图和细胞图的动态连接。 在这样的实施方案中，与非空间选择的核酸数据相反，途径图连接到空间定位的区域核酸数据（例如序列数据）。 路径图和细胞图谱数据可以被链接，使得交互导致对链接的图的改变或更新，诸如显示由用户更新节点值或状态所指示的路径图特征的细胞的选择或突出显示，以对应于该 的用户选择的单元格或单元格。

公开(公告)号：US20130332135A1

公开(公告)日：2013-12-12

申请号：US13967123

申请日：2013-08-14

Applicant: General Electric Company

Inventor： John Frederick Graf ,  Brion Daryl Sarachan ,  Mary Elizabeth Spilker

IPC: G06F19/00

CPC classification number: G09B23/28 ,  G06K9/6228 ,  G06T7/0012 ,  G06T2207/30004 ,  G16C99/00 ,  G16H50/50

Abstract: The quantitative evaluation of biomarker-probe activity is disclosed. In certain embodiments, the biomarker-probe activity may be quantified and analyzed using biodistributions generated using a model. In some embodiments, such biodistributions may be used to generate simulated images from which quantitative thresholds may be derived. In some embodiments, the quantitative thresholds may be used to analyze the biodistributions.

Abstract translation: 公开了生物标志物探针活性的定量评估。 在某些实施方案中，可以使用使用模型生成的生物分布来量化和分析生物标记探针活性。 在一些实施例中，这样的生物分布可以用于产生可以从其导出定量阈值的模拟图像。 在一些实施方案中，定量阈值可用于分析生物分布。