公开(公告)号：US20150184196A1

公开(公告)日：2015-07-02

申请号：US14644000

申请日：2015-03-10

Applicant: Corning Incorporated

Inventor： Na Li ,  Jie Wang ,  Christopher J. Patten

IPC: C12N15/85

CPC classification number: C07K14/705 ,  A01N1/021 ,  A01N1/0284 ,  C12N5/00 ,  C12N5/067 ,  C12N5/069 ,  C12N15/85 ,  C12N2510/00 ,  G01N33/5008 ,  G01N2333/705

Abstract: The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins and/or drug metabolizing enzymes. Advantageously, such cells provide a cost-efficient consumable product that streamlines the process of screening whether drug candidates are substrates or inhibitors of drug transporter proteins and/or drug metabolizing enzymes.

Abstract translation: 本发明公开了用于筛选瞬时过表达一种或多种药物转运蛋白和/或药物代谢酶的药物候选物的冷冻保存重组细胞。 有利地，这样的细胞提供了一种成本有效的消耗品，其简化了筛选药物候选物是药物转运蛋白和/或药物代谢酶的底物或抑制剂的过程。

公开(公告)号：US20210169085A1

公开(公告)日：2021-06-10

申请号：US17180157

申请日：2021-02-19

Applicant: CORNING INCORPORATED

Inventor： Dayue Jiang ,  Kaitlyn Mary Matias ,  Kevin Andrew Vasilakos ,  Jianguo Wang ,  Jie Wang

IPC: A01N59/20 ,  C08K3/40 ,  C11D3/48 ,  C08K13/02 ,  C09K9/00 ,  C03C14/00 ,  C03C4/00 ,  A41D31/30 ,  C09D7/40 ,  C09D5/02 ,  C09D5/14 ,  C08K3/22 ,  C09D7/61 ,  C08K3/015

Abstract: A method of making an antimicrobial composite article, including the steps: providing a matrix comprising a polymeric material; providing a plurality of second phase particles comprising an antimicrobial agent; melting the matrix to form a matrix melt; distributing the plurality of second phase particles in the matrix melt at a second phase volume fraction to form a composite melt; forming a composite article from the composite melt; and treating the composite article to form an antimicrobial composite article having an exterior surface comprising an exposed portion of the matrix and the plurality of second phase particles. The distributing step can employ an extrusion process. The forming a composite article step can employ an injection molding process. The treating step can employ abrading and plasma-treating the article to define the exterior surface.

公开(公告)号：US10959434B2

公开(公告)日：2021-03-30

申请号：US15769943

申请日：2016-10-20

Applicant: CORNING INCORPORATED

Inventor： Dayue Jiang ,  Kaitlyn Mary Matias ,  Kevin Andrew Vasilakos ,  Jianguo Wang ,  Jie Wang

IPC: C03C3/00 ,  A01N59/20 ,  C03C4/00 ,  C08K3/40 ,  C03C14/00 ,  C08K3/22 ,  C08K13/02 ,  C09K9/00 ,  C09D7/61 ,  C09D7/40 ,  C09D5/14 ,  C09D5/02 ,  C11D3/48 ,  A41D31/30 ,  C08K3/015

Abstract: A method of making an antimicrobial composite article, including the steps: providing a matrix comprising a polymeric material; providing a plurality of second phase particles comprising an antimicrobial agent; melting the matrix to form a matrix melt; distributing the plurality of second phase particles in the matrix melt at a second phase volume fraction to form a composite melt; forming a composite article from the composite melt; and treating the composite article to form an antimicrobial composite article having an exterior surface comprising an exposed portion of the matrix and the plurality of second phase particles. The distributing step can employ an extrusion process. The forming a composite article step can employ an injection molding process. The treating step can employ abrading and plasma-treating the article to define the exterior surface.

公开(公告)号：US20190263884A1

公开(公告)日：2019-08-29

申请号：US16407860

申请日：2019-05-09

Applicant: Corning Incorporated

Inventor： Na Li ,  Jie Wang ,  Christopher J. Patten

IPC: C07K14/705 ,  C12N5/071 ,  A01N1/02 ,  G01N33/50 ,  C12N5/00 ,  C12N15/85

Abstract: The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins and/or drug metabolizing enzymes. Advantageously, such cells provide a cost-efficient consumable product that streamlines the process of screening whether drug candidates are substrates or inhibitors of drug transporter proteins and/or drug metabolizing enzymes.

公开(公告)号：US10336806B2

公开(公告)日：2019-07-02

申请号：US15988819

申请日：2018-05-24

Applicant: Corning Incorporated

Inventor： Na Li ,  Jie Wang ,  Christopher J. Patten

IPC: C12N5/071 ,  C12N5/00 ,  C12N5/02 ,  C07K14/705 ,  C12N15/85 ,  A01N1/02 ,  G01N33/50

Abstract: The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter proteins and/or drug metabolizing enzymes. Advantageously, such cells provide a cost-efficient consumable product that streamlines the process of screening whether drug candidates are substrates or inhibitors of drug transporter proteins and/or drug metabolizing enzymes.