公开(公告)号：US09015648B2

公开(公告)日：2015-04-21

申请号：US12200762

申请日：2008-08-28

申请人： Ganesh Radhakrishnan ,  Lili Liu ,  Anurag Aggarwal ,  Vishal Saxena

发明人： Ganesh Radhakrishnan ,  Lili Liu ,  Anurag Aggarwal ,  Vishal Saxena

IPC分类号： G06F9/44 ,  G06Q10/06

CPC分类号： G06Q10/06 ,  G06Q10/067

摘要： In one embodiment, a method of performing a merge operation can include: mapping a business process modeling notation (BPMN) model to a business process execution language (BPEL) model; modifying the BPMN model to form a modified BPMN model; modifying the BPEL model to form a modified BPEL model; when the merge operation is a forward merge operation: exporting the modified BPMN model to an exported BPEL model; performing an activity level outline merge for added information technology (IT) scopes and branches from the modified BPEL model; performing an activity level detail merge for added IT details from the modified BPEL model; and performing an attribute level merge for updated branch conditions in the merged BPEL model; and when the merge operation is a reverse merge operation, adding scopes and branches from the modified BPEL model to the BPMN model.

摘要翻译： 在一个实施例中，执行合并操作的方法可以包括：将业务流程建模符号（BPMN）模型映射到业务流程执行语言（BPEL）模型; 修改BPMN模型以形成修改后的BPMN模型; 修改BPEL模型以形成修改的BPEL模型; 当合并操作是前向合并操作时：将修改的BPMN模型导出到导出的BPEL模型; 从修改的BPEL模型执行附加信息技术（IT）范围和分支的活动级别大纲合并; 执行活动级详细信息合并，以从修改的BPEL模型中添加IT细节; 以及对所合并的BPEL模型中的更新的分支条件执行属性级合并; 并且当合并操作是反向合并操作时，将修改的BPEL模型中的范围和分支添加到BPMN模型。

公开(公告)号：US20100305650A1

公开(公告)日：2010-12-02

申请号：US12787868

申请日：2010-05-26

申请人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

发明人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

IPC分类号： A61N1/365

CPC分类号： A61N1/36564 ,  A61N1/36542 ,  A61N1/36585

摘要： A system and method for pacing rate control in a cardiac rhythm management (CRM) system. The method includes acquiring a pressure signal representative of coronary venous pressure (CVP) from a pressure sensor implanted within a coronary vein of the patient and generating a CVP waveform from the pressure signal. A pacing stimulus is applied to the patient's heart, and the pacing rate is increased in response to increases in patient's metabolic demand. The CVP index is monitored during the pacing rate increase, and the CRM system detects a reduction in the patient's hemodynamic performance based on the CVP index and establishes a maximum rate setting based on the pacing rate corresponding to the reduction in the patient's hemodynamic performance.

摘要翻译： 用于心律管理（CRM）系统中起搏速率控制的系统和方法。 该方法包括从植入患者冠状静脉内的压力传感器获取代表冠状静脉压（CVP）的压力信号，并从压力信号产生CVP波形。 对患者的心脏施加起搏刺激，并且响应于患者代谢需求的增加而起搏速率增加。 在起搏速率增加期间监测CVP指数，并且CRM系统基于CVP指数检测患者血液动力学性能的降低，并且基于与患者血液动力学性能的降低相对应的起搏速率建立最大速率设置。

公开(公告)号：US07657324B2

公开(公告)日：2010-02-02

申请号：US10617881

申请日：2003-07-14

申请人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

发明人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

IPC分类号： A61N1/05

CPC分类号： A61N1/0565 ,  A61N1/056 ,  A61N1/0573

摘要： A seal adapted for use with medical devices is provided. The medical device may be a lead having a distal tip adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead assembly in one embodiment includes an atraumatic tip. A seal is provided within the lead tip assembly, which prevents or limits further entry of fluids through the lead tip. The lead may be a left ventricular lead with a hemostasis mechanism provided therewithin.

摘要翻译： 提供适于与医疗装置一起使用的密封件。 医疗装置可以是具有适于植入在心脏上或周围的远端的引线，并且用于连接到用于监测或刺激心脏活动的系统。 在一个实施例中的引线组件包括无创伤的尖端。 在引线端头组件内提供密封件，其防止或限制流体进一步进入引线尖端。 铅可以是在其中设置有止血机构的左心室导联。

公开(公告)号：US20090299427A1

公开(公告)日：2009-12-03

申请号：US12431301

申请日：2009-04-28

申请人： Lili Liu ,  Allan C. Shuros

发明人： Lili Liu ,  Allan C. Shuros

IPC分类号： A61N1/362 ,  A61N1/05 ,  A61B5/02

CPC分类号： A61N1/057 ,  A61B5/02 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/1076 ,  A61B5/1107 ,  A61B5/686 ,  A61B2562/0261 ,  A61N1/3627 ,  A61N1/36578 ,  A61N2001/0585

摘要： A system and method for estimating a hemodynamic performance parameter value of a patient's heart. The system includes a pulse generator and a medical electrical lead implanted partially within a coronary vein of the heart. The lead includes at least one sensor located within the coronary vein configured to generate a signal indicative of at least one dimensional parameter of the coronary vein. Changes in the dimensional parameter during one or more cardiac cycles are measured. The hemodynamic performance parameter is estimated based on the change in the dimensional parameter of the coronary vein.

摘要翻译： 一种用于估计患者心脏的血液动力学性能参数值的系统和方法。 该系统包括部分地植入心脏冠状静脉内的脉冲发生器和医用电线。 引线包括位于冠状静脉内的至少一个传感器，其构造成产生指示冠状静脉的至少一维参数的信号。 测量一个或多个心动周期内尺寸参数的变化。 基于冠状静脉尺寸参数的变化估计血流动力学性能参数。

公开(公告)号：US20090062882A1

公开(公告)日：2009-03-05

申请号：US11895999

申请日：2007-08-28

申请人： Yi Zhang ,  Shantha Arcot-Krishnamurthy ,  Lili Liu ,  Kenneth Beck ,  Kent Lee ,  Jonathan Kwok ,  Zheng Lin

发明人： Yi Zhang ,  Shantha Arcot-Krishnamurthy ,  Lili Liu ,  Kenneth Beck ,  Kent Lee ,  Jonathan Kwok ,  Zheng Lin

IPC分类号： A61N1/36

CPC分类号： A61N1/3601 ,  A61N1/0558

摘要： An inspiratory muscle stimulation system uses an implantable medical device to deliver stimulation to control diaphragmatic contractions for slower and deeper breathing, thereby conditioning and strengthening inspiratory muscles. In various embodiments, respiratory and/or cardiac performance are monitored for controlling parameters of the stimulation.

摘要翻译： 吸气肌肉刺激系统使用可植入医疗装置来输送刺激以控制膈肌收缩以减慢和深呼吸，从而调节和加强吸气肌肉。 在各种实施例中，监测呼吸和/或心脏性能以控制刺激的参数。

公开(公告)号：US06635677B2

公开(公告)日：2003-10-21

申请号：US10079049

申请日：2002-02-19

申请人： Stanton L. Gerson ,  Lili Liu

发明人： Stanton L. Gerson ,  Lili Liu

IPC分类号： A61K3113

CPC分类号： A61K45/06 ,  A61K31/13 ,  A61K31/175 ,  A61K31/33 ,  A61K31/445 ,  A61K31/495 ,  A61K31/513 ,  A61K31/522 ,  A61K31/53 ,  A61K31/704 ,  A61K31/7072 ,  A61K31/715 ,  A61K41/00 ,  A61K2300/00

摘要： This invention generally relates to novel compositions and methods for the treatment of certain cancers. Additionally, this invention relates to novel compositions and methods to screen drugs for the treatment of certain cancers. Specifically, the invention contemplates that temozolomide and methoxyamine, in combination or in sequence, shall be used as a treatment for certain tumors that are resistant to treatment by temozolomide alone. Additionally, methoxyamine is contemplated for methods of treatment of cancer, wherein methoxyamine is used, in combination or in sequence, with other anticancer drugs or agents.

公开(公告)号：US06465448B1

公开(公告)日：2002-10-15

申请号：US09373693

申请日：1999-08-13

申请人： Stanton L. Gerson ,  Lili Liu

发明人： Stanton L. Gerson ,  Lili Liu

IPC分类号： A61K3133

CPC分类号： A61K31/33 ,  A61K31/13 ,  A61K31/445 ,  A61K31/53 ,  A61K2300/00

摘要： This invention generally relates to novel compositions and methods for the treatment of certain cancers. Additionally, this invention relates to novel compositions and methods to screen drugs for the treatment of certain cancers. Specifically, the invention contemplates that temozolomide and methoxyamine, in combination or in sequence, shall be used as a treatment for certain tumors that are resistant to treatment by temozolomide alone.

摘要翻译： 本发明一般涉及用于治疗某些癌症的新型组合物和方法。 此外，本发明涉及筛选用于治疗某些癌症的药物的新型组合物和方法。 具体地说，本发明考虑到组合或按顺序使用替莫唑胺和甲氧胺作为治疗单独使用替莫唑胺治疗的某些肿瘤。

公开(公告)号：US20140184656A1

公开(公告)日：2014-07-03

申请号：US14009935

申请日：2012-05-16

申请人： Cuicui Tian ,  Lili Liu ,  Wenfeng Xing

发明人： Cuicui Tian ,  Lili Liu ,  Wenfeng Xing

IPC分类号： G09G3/34

CPC分类号： G09G3/3406 ,  G02B6/0038 ,  G02F1/133615 ,  G09G3/36 ,  G09G2320/062 ,  G09G2320/0646

摘要： The present application provides a an image compensation method for side-emitting backlight comprising steps of: S1, dividing the display screen into several regions; S2, arranging virtual light sources at one side of each region where actual light sources are located for imitating the actual light sources; S3, inputting a pixel value and a coordinate of the point to be compensated; S4, computing a ratio value between an all-full-lighting backlight brightness of the point to be compensated when fully lighted and an all-reduced backlight brightness of the point to be compensated when reduced in brightness; S5, obtaining a compensation factor of the point to be compensated, according to the ratio value; S6, compensating the pixel value of the point to be compensated by using the compensation factor; S7, determining whether all the points to be compensated in the image to be compensated have been compensated or not.

摘要翻译： 本发明提供了一种用于侧面发射背光的图像补偿方法，包括以下步骤：S1，将显示屏分成几个区域; S2，在实际光源所在的每个区域的一侧设置用于模拟实际光源的虚拟光源; S3，输入要补偿的点的像素值和坐标; S4，计算在完全点亮时要补偿的点的全全光照明背光亮度与亮度降低时要补偿的点的全降光背光亮度之间的比值; S5，根据比值获得待补偿点的补偿因子; S6，通过使用补偿因子补偿要补偿的点的像素值; S7，确定要补偿的图像中要补偿的所有点是否已被补偿。

公开(公告)号：US08423140B2

公开(公告)日：2013-04-16

申请号：US12787630

申请日：2010-05-26

申请人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

发明人： Barun Maskara ,  Lili Liu ,  Guy Alvarez ,  Scott A. Meyer

IPC分类号： A61N1/08

CPC分类号： A61N1/36564

摘要： A system and method for detecting and treating symptoms of early decompensation utilizing a cardiac rhythm management. The system applies an electrical stimulus to the patient's heart at a first set of pacing parameters including a lower rate limit (LRL) setting, and acquires a coronary venous pressure (CVP) signal from a pressure sensor implanted in a coronary vein of the patient. An average coronary venous end diastolic pressure (CV-EDP) value is calculated from the CVP signal. The system monitors the average CV-EDP value over a predetermined interval, and dynamically adjusts the LRL setting responsive to the detection of a first or a second predetermined event based on the average CV-EDP value.

摘要翻译： 一种利用心律管理检测和治疗早期失代偿症状的系统和方法。 该系统以包括较低速率限制（LRL）设置在内的第一组起搏参数对患者的心脏施加电刺激，并从植入患者冠状静脉的压力传感器获取冠状静脉压（CVP）信号。 根据CVP信号计算平均冠状静脉舒张末期压（CV-EDP）值。 该系统在预定间隔内监视平均CV-EDP值，并且响应于基于平均CV-EDP值的第一或第二预定事件的检测动态地调整LRL设置。

公开(公告)号：US08324282B2

公开(公告)日：2012-12-04

申请号：US10505400

申请日：2003-02-19

申请人： Stanton L. Gerson ,  Lili Liu

发明人： Stanton L. Gerson ,  Lili Liu

IPC分类号： A61K31/13 ,  A61K31/33

CPC分类号： A61K45/06 ,  A61K31/13 ,  A61K31/175 ,  A61K31/33 ,  A61K31/445 ,  A61K31/495 ,  A61K31/513 ,  A61K31/522 ,  A61K31/53 ,  A61K31/704 ,  A61K31/7072 ,  A61K31/715 ,  A61K41/00 ,  A61K2300/00

摘要： This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents.

摘要翻译： 本申请提供了用于治疗某些癌症的组合物和方法。 在某种程度上，该应用基于认识到靶向DNA中的无基因损伤或AP位点的某些分子改善，增强或增强某些抗癌剂的化学疗效。