公开(公告)号：US20200017501A1

公开(公告)日：2020-01-16

申请号：US16578733

申请日：2019-09-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ian S. YOUNG ,  Sanjeev Gangwar ,  Shoshana L. Posy ,  Yam B. Poudel ,  Prasanna Sivaprakasam

IPC: C07D473/18

Abstract: Compounds having a structure according to formula (I), (II), or (III) where R1, R2, R3, R5 X1, X2, and X3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US10233192B2

公开(公告)日：2019-03-19

申请号：US15677959

申请日：2017-08-15

Applicant: WILLIAM MARSH RICE UNIVERSITY ,  BRISTOL-MYERS SQUIBB COMPANY ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Kyriacos C. Nicolaou ,  Min Lu ,  Debashis Mandal ,  Sanjeev Gangwar ,  Naidu S. Chowdari ,  Yam B. Poudel

IPC: C07D491/08 ,  A61K47/68

Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.

公开(公告)号：US20190055246A1

公开(公告)日：2019-02-21

申请号：US16103601

申请日：2018-08-14

Applicant: Bristol-Myers Squibb Company

Inventor： Liqi HE ,  Sanjeev Gangwar ,  Shoshana L. Posy ,  Yam B. Poudel ,  Prasanna Sivaprakasam

IPC: C07D473/18 ,  A61K47/60 ,  A61K47/68 ,  A61K31/52

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.