Invention Application
- Patent Title: TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A HETEROBIARYL MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR
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Application No.: US16103601Application Date: 2018-08-14
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Publication No.: US20190055246A1Publication Date: 2019-02-21
- Inventor: Liqi HE , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam
- Applicant: Bristol-Myers Squibb Company
- Main IPC: C07D473/18
- IPC: C07D473/18 ; A61K47/60 ; A61K47/68 ; A61K31/52
Abstract:
Compounds having a structure according to formula (I) or (II) where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
Information query
