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公开(公告)号：US12097241B2
公开(公告)日：2024-09-24
申请号：US17573238
申请日：2022-01-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
CPC classification number: A61K38/18 , A61K38/2221 , C07K1/1077 , C07K14/64 , A61K38/00 , A61K45/06 , A61K47/64 , A61P9/00
Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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公开(公告)号：US20220315569A1
公开(公告)日：2022-10-06
申请号：US17836596
申请日：2022-06-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Wei Meng , Hannguang J. Chao , Heather Finlay , R. Michael Lawrence , Michael C. Myers
IPC: C07D413/10 , C07D239/54 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D413/06 , C07D417/06 , C07D417/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20220211812A1
公开(公告)日：2022-07-07
申请号：US17573238
申请日：2022-01-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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Patent Agency Ranking
公开(公告)号：US20210196791A1
公开(公告)日：2021-07-01
申请号：US17198939
申请日：2021-03-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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公开(公告)号：US10266578B2
公开(公告)日：2019-04-23
申请号：US15891492
申请日：2018-02-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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公开(公告)号：US20190002441A1
公开(公告)日：2019-01-03
申请号：US16122975
申请日：2018-09-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , C07D403/02 , C07D417/14 , A61K31/505 , C07D239/557 , C07D401/14 , C07D401/06 , C07D471/04 , C07D239/54 , C07D239/545 , C07D403/14
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10106528B2
公开(公告)日：2018-10-23
申请号：US15468230
申请日：2017-03-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Zulan Pi , Donna M. Bilder , Robert Paul Brigance , Heather Finlay , Wen Jiang , James A. Johnson , R. Michael Lawrence , Wei Meng , Michael C. Myers , Monique Phillips , George O. Tora , Xiaojun Zhang
IPC: C07D403/06 , A61K31/505 , C07D239/54 , C07D239/545 , C07D401/14 , C07D403/02 , C07D417/14 , C07D471/04 , C07D401/06 , C07D403/14 , C07D239/557
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20160355507A1
公开(公告)日：2016-12-08
申请号：US15171276
申请日：2016-06-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D413/14
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
Abstract translation: 其中所有变量如说明书中所定义，以及包含任何这些新化合物的组合物。 这些化合物是可用作药物的APJ激动剂。
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