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公开(公告)号：US11344889B2
公开(公告)日：2022-05-31
申请号：US16603648
申请日：2019-04-26
Inventor： Haochen Cui , Peizhi Cai , Chuncheng Che , Fengchun Pang , Yingying Zhao , Yue Geng , Le Gu , Nan Zhao , Yuelei Xiao , Hui Liao
Abstract: The embodiments of the present disclosure relate to a microfluidic chip. The microfluidic chip may include a substrate. The substrate may include an electrode layer on a base substrate, a dielectric layer on the electrode layer, and a lyophobic layer on the dielectric layer. The electrode layer may include a plurality of electrode units. Each of the plurality of electrode units may be configured to realize both droplet detection and droplet driving in response to a detection signal and a driving signal respectively.
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公开(公告)号：US20210322973A1
公开(公告)日：2021-10-21
申请号：US16603648
申请日：2019-04-26
Inventor： Haochen Cui , Peizhi Cai , Chuncheng Che , Fengchun Pang , Yingying Zhao , Yue Geng , Le Gu , Nan Zhao , Yuelei Xiao , Hui Liao
Abstract: The embodiments of the present disclosure relate to a microfluidic chip. The microfluidic chip may include a substrate. The substrate may include an electrode layer on a base substrate, a dielectric layer on the electrode layer, and a lyophobic layer on the dielectric layer. The electrode layer may include a plurality of electrode units. Each of the plurality of electrode units may be configured to realize both droplet detection and droplet driving in response to a detection signal and a driving signal respectively.
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公开(公告)号：US20210187507A1
公开(公告)日：2021-06-24
申请号：US16898516
申请日：2020-06-11
Inventor： Hui Liao , Yingying Zhao , Wenliang Yao , Bolin Fan , Nan Zhao , Le Gu , Yongjia Gao
Abstract: The present disclosure discloses a sample preliminary screening chip, a specimen detecting method and a screening device. A data processor may be configured to control a sample solution containing a specimen to be added into a preliminary screening inlet of the sample preliminary screening chip, and control the sample solution in the preliminary screening inlet to enter a channel, successively to flow through a first preliminary screening area and a second preliminary screening area, and to flow out from a preliminary screening outlet so as to store a liquid with the specimen in a first preliminary screening area. In this way, the liquid containing the specimen may be screened preliminarily.
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公开(公告)号：US11865538B2
公开(公告)日：2024-01-09
申请号：US16757902
申请日：2019-03-27
Inventor： Wenliang Yao , Nan Zhao , Peizhi Cai , Fengchun Pang , Yue Geng , Le Gu , Yuelei Xiao , Hui Liao , Yingying Zhao , Bolin Fan
IPC: B01L3/00 , G01N33/487 , H01L27/12
CPC classification number: B01L3/502715 , G01N33/48707 , H01L27/1214 , B01L2300/0645 , B01L2300/0819
Abstract: A biological detection chip, a biological detection device, and a detection method thereof are disclosed. The biological detection chip includes a first base substrate and a plurality of detection units arranged in an array along a row direction and a column direction on the first base substrate. Each of the plurality of detection units includes a thin film transistor and an electrode, the thin film transistor is on the first base substrate and includes a gate electrode, a source electrode, and a drain electrode, and the electrode is on a side of the thin film transistor away from the first base substrate and is connected to the drain electrode, and the electrode is configured to carry a biological material to be detected.
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公开(公告)号：US11691147B2
公开(公告)日：2023-07-04
申请号：US16641126
申请日：2019-07-26
Inventor： Mingyang Lv , Yue Li , Yanchen Li , Jinyu Li , Dawei Feng , Yu Zhao , Dong Wang , Wang Guo , Hailong Wang , Yue Geng , Peizhi Cai , Fengchun Pang , Le Gu , Chuncheng Che , Haochen Cui , Yingying Zhao , Nan Zhao , Yuelei Xiao , Hui Liao
IPC: B01L3/00
CPC classification number: B01L3/50273 , B01L3/502792 , B01L2200/10 , B01L2300/0645 , B01L2300/165 , B01L2400/0427
Abstract: A digital microfluidic chip and a digital microfluidic system. The digital microfluidic chip comprises: an upper substrate and a lower substrate arranged opposite to each other; multiple driving circuits and multiple addressing circuits disposed between the lower substrate and the upper substrate; and a control circuit, electrically connected to the driving circuits and the addressing circuits. The control circuit is configured to apply, in a driving stage, a driving voltage to each driving circuit, such that a droplet is controlled to move inside a droplet accommodation space according to a set path, measure, in a detection stage, after a bias voltage is applied to each addressing circuit, a charge loss amount of each addressing circuit, and to determine the position of the droplet according to the charge loss amount. The charge loss amount of each addressing circuit is related to the intensity of received external light.
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Patent Agency Ranking
公开(公告)号：US11498068B2
公开(公告)日：2022-11-15
申请号：US16632931
申请日：2019-01-02
Inventor： Wenliang Yao , Haochen Cui , Peizhi Cai , Yuelei Xiao , Fengchun Pang , Yue Geng , Le Gu , Nan Zhao , Hui Liao , Yingying Zhao , Chuncheng Che
IPC: B01L3/00
Abstract: A microfluidic device, a microfluidic detection assembly and a detection method for the microfluidic device. The microfluidic device includes a first substrate and a second substrate; the first substrate and the second substrate are oppositely arranged to define a channel between the first substrate and the second substrate, the channel is configured for liquid to flow, the first substrate includes a base substrate and a plurality of control assemblies which are arranged on the base substrate along an extending direction of the channel, each of the plurality of control assemblies includes: a first electrode, a second electrode and a plurality of coils, and the first electrode is configured to input currents into the plurality of coils, and the plurality of coils are connected in parallel to the second electrode.
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27.发明授权公开(公告)号：US11351546B2
公开(公告)日：2022-06-07
申请号：US16314679
申请日：2018-06-08
Inventor： Yue Geng , Peizhi Cai , Fengchun Pang , Le Gu , Chuncheng Che , Hailin Xue , Xibin Shao
IPC: B01L3/00
Abstract: A microfluidic chip and controlling method are provided. The microfluidic chip includes a microfluidic substrate, comprising a first substrate, a droplet driving assembly over the first substrate, and a temperature detection assembly. The droplet driving assembly includes a first electrode layer having a plurality of control electrodes, and each of the plurality of control electrodes is configured as part of a driving unit to drive a droplet to move along a predetermined path over the microfluidic substrate. The temperature detection assembly comprises at least one temperature sensor. The at least one temperature sensor positionally corresponds to the plurality of control electrodes such that each of the at least one temperature sensor detects a temperature at a position associated with one of the plurality of control electrodes corresponding to the each of the at least one temperature sensor.
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公开(公告)号：US11219900B2
公开(公告)日：2022-01-11
申请号：US16334126
申请日：2018-09-12
Inventor： Fengchun Pang , Peizhi Cai , Yue Geng , Le Gu , Chuncheng Che , Hailin Xue , Xibin Shao
IPC: B01L3/00 , H01L27/12 , H01L27/144
Abstract: A digital microfluidic device includes a thin film transistor driving substrate. The thin film transistor driving substrate includes a first base substrate; a plurality of sample actuating units; a plurality of sample position detecting units; a dielectric insulating layer on a side of the plurality of sample actuating units and the plurality of sample position detecting units distal to the first base substrate; and a first hydrophobic layer on a side of the dielectric insulating layer distal to the first base substrate. Each of the plurality of sample actuating units includes a first electrode configured to drive transportation of a liquid droplet on the digital microfluidic device. Each of the plurality of sample position detecting units includes a photosensor configured to detect presence or absence of the liquid droplet on a position corresponding to the photosensor.
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公开(公告)号：US11169109B2
公开(公告)日：2021-11-09
申请号：US16235455
申请日：2018-12-28
Inventor： Fengchun Pang , Peizhi Cai , Yue Geng , Le Gu , Chuncheng Che
IPC: G01N27/27 , G01N27/403 , B01L3/00
Abstract: An electrochemical detection chip includes a first substrate and a second substrate opposite to each other, a plurality of driving electrodes, first detection electrodes and second detection electrodes. The plurality of driving electrodes are arranged on a side of the first substrate facing toward the second substrate and are arranged independently. The first detection electrodes and the second detection electrodes are arranged at a plurality of positions on a side of the second substrate facing toward the first substrate that are directly opposite at least a part of the plurality of driving electrodes, and are spaced apart from each other.
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公开(公告)号：US20210322987A1
公开(公告)日：2021-10-21
申请号：US16334126
申请日：2018-09-12
Inventor： Fengchun Pang , Peizhi Cai , Yue Geng , Le Gu , Chuncheng Che , Hailin Xue , Xibin Shao
IPC: B01L3/00 , H01L27/12 , H01L27/144
Abstract: A digital microfluidic device includes a thin film transistor driving substrate. The thin film transistor driving substrate includes a first base substrate; a plurality of sample actuating units; a plurality of sample position detecting units; a dielectric insulating layer on a side of the plurality of sample actuating units and the plurality of sample position detecting units distal to the first base substrate; and a first hydrophobic layer on a side of the dielectric insulating layer distal to the first base substrate. Each of the plurality of sample actuating units includes a first electrode configured to drive transportation of a liquid droplet on the digital microfluidic device. Each of the plurality of sample position detecting units includes a photosensor configured to detect presence or absence of the liquid droplet on a position corresponding to the photosensor.
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