公开(公告)号：US11845783B2

公开(公告)日：2023-12-19

申请号：US17385714

申请日：2021-07-26

Applicant: Altor BioScience, LLC.

Inventor： Hing C. Wong ,  Peter Rhode ,  Bai Liu ,  Xiaoyun Zhu ,  Kai-Ping Han

IPC: C12N15/62 ,  C12N15/09 ,  C07K14/715 ,  C12P21/00 ,  A61K38/17 ,  A61K45/06 ,  C07K16/28 ,  C07K14/54 ,  A61K38/20 ,  C07K16/18 ,  A61K39/395 ,  A61K38/00

CPC classification number: C07K14/7155 ,  A61K38/1793 ,  A61K38/2086 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/5443 ,  C07K16/18 ,  C07K16/2887 ,  C12N15/09 ,  C12N15/62 ,  C12P21/00 ,  A61K38/00 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/30 ,  A61K38/2086 ,  A61K2300/00 ,  A61K38/1793 ,  A61K2300/00

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor α/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

公开(公告)号：US20230257437A1

公开(公告)日：2023-08-17

申请号：US18305965

申请日：2023-04-24

Applicant: Altor BioScience LLC

Inventor： Hing C. Wong ,  Peter Rhode ,  Xiaoyun Zhu ,  Kai-Ping Han

IPC: C07K14/54 ,  C12N15/09 ,  A61K38/20 ,  C07K14/715 ,  C12N15/62 ,  C07K14/725 ,  C07K16/28 ,  G01N33/569 ,  A61K38/17

CPC classification number: C07K14/5443 ,  C12N15/09 ,  A61K38/2086 ,  C07K14/7155 ,  C12N15/62 ,  C07K14/7051 ,  C07K16/28 ,  G01N33/56977 ,  A61K38/1774 ,  A61K38/1793 ,  C07K16/18

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

公开(公告)号：US20230241175A1

公开(公告)日：2023-08-03

申请号：US18176196

申请日：2023-02-28

Applicant: Altor Bioscience, LLC

Inventor： Bai Liu ,  Peter Rhode ,  Wenxin Xu ,  Hing C. Wong

IPC: A61K38/20 ,  A61K39/395 ,  C07K16/28 ,  C07K16/32 ,  C07K14/54 ,  C07K14/715 ,  C07K19/00 ,  A61K39/04

CPC classification number: A61K38/2086 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2887 ,  C07K16/32 ,  C07K14/5443 ,  C07K14/7155 ,  C07K19/00 ,  A61K39/04 ,  C07K2319/30 ,  C07K2317/732 ,  C07K14/35

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

公开(公告)号：US20230233649A1

公开(公告)日：2023-07-27

申请号：US18175112

申请日：2023-02-27

Applicant: Altor Bioscience, LLC

Inventor： Bai Liu ,  Peter Rhode ,  Wenxin Xu ,  Hing C. Wong

IPC: A61K38/20 ,  A61K39/395 ,  C07K16/28 ,  C07K16/32 ,  C07K14/54 ,  C07K14/715 ,  C07K19/00 ,  A61K39/04

CPC classification number: A61K38/2086 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2887 ,  C07K16/32 ,  C07K14/5443 ,  C07K14/7155 ,  C07K19/00 ,  A61K39/04 ,  C07K2319/30 ,  C07K2317/732 ,  C07K14/35

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

公开(公告)号：US11571470B2

公开(公告)日：2023-02-07

申请号：US17486683

申请日：2021-09-27

Applicant: Altor Bioscience LLC

Inventor： Warren D. Marcus ,  Robert Newman ,  Bai Liu ,  Lijing You ,  Lin Kong ,  Peter Rhode ,  Hing C. Wong

IPC: C07K14/54 ,  A61K39/00 ,  C12N15/62 ,  A61K47/68 ,  C07K16/28 ,  A61P35/00 ,  C07K14/715

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

公开(公告)号：US20220305087A1

公开(公告)日：2022-09-29

申请号：US17825959

申请日：2022-05-26

Applicant: Altor Bioscience, LLC

Inventor： Bai Liu ,  Peter Rhode ,  Wenxin Xu ,  Hing C. Wong

IPC: A61K38/20 ,  A61K39/395 ,  C07K16/28 ,  C07K16/32 ,  C07K14/54 ,  C07K14/715 ,  C07K19/00 ,  A61K39/04

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

公开(公告)号：US11369679B2

公开(公告)日：2022-06-28

申请号：US16752606

申请日：2020-01-24

Applicant: Altor Bioscience, LLC.

Inventor： Hing C. Wong ,  Warren Marcus ,  Bai Liu ,  Wenxin Xu ,  Robert Newman ,  Karen Kage ,  Lijing You ,  Peter Rhode ,  Patrick Soon-Shiong

IPC: A61K39/395 ,  C07K16/28 ,  C07K14/54 ,  A61K38/20 ,  A61P31/18 ,  A61P35/00 ,  A61K38/00 ,  C07K16/10 ,  C07K14/715 ,  C07K16/36 ,  A61K39/00 ,  A61K38/17

Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.

公开(公告)号：US20210008167A1

公开(公告)日：2021-01-14

申请号：US16508279

申请日：2019-07-10

Applicant: Altor Bioscience, LLC

Inventor： Hing C. Wong ,  Peter Rhode ,  Xiaoyun Zhu

IPC: A61K38/20 ,  A61K33/243 ,  A61K38/17 ,  A61P35/00

Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.

公开(公告)号：US20190328838A1

公开(公告)日：2019-10-31

申请号：US16510835

申请日：2019-07-12

Applicant: Altor Bioscience, LLC

Inventor： Jinghai Wen ,  Wenxin Xu ,  Peter Rhode ,  Hing C. Wong

IPC: A61K38/20 ,  A61K38/21 ,  A61K38/17 ,  A61K45/06 ,  A61K38/08 ,  A61K31/7068 ,  A61K33/24

Abstract: The invention provides methods of treating neoplasia, for example bladder cancer, by administering an IL-2 fusion protein and one or more therapeutic agents, where the IL-2 fusion protein does not necessarily have to target the neoplasia.

公开(公告)号：US20250066442A1

公开(公告)日：2025-02-27

申请号：US18933787

申请日：2024-10-31

Applicant: Altor BioScience LLC

Inventor： Hing C. Wong ,  Peter Rhode ,  Xiaoyun Zhu ,  Kai-Ping Han

IPC: C07K14/54 ,  A61K38/00 ,  A61K38/17 ,  A61K38/20 ,  C07K14/715 ,  C07K14/725 ,  C07K16/18 ,  C07K16/28 ,  C12N15/09 ,  C12N15/62 ,  C12P21/00 ,  G01N33/569

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.