公开(公告)号：US20250018020A1

公开(公告)日：2025-01-16

申请号：US18896286

申请日：2024-09-25

Applicant: Altor Bioscience LLC

Inventor： Warren D. Marcus ,  Robert Newman ,  Bai Liu ,  Lijing You ,  Lin Kong ,  Peter Rhode ,  Hing C. Wong

IPC: A61K39/00 ,  A61K47/68 ,  A61P35/00 ,  C07K14/54 ,  C07K14/715 ,  C07K16/28 ,  C12N15/62

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

公开(公告)号：US11992516B2

公开(公告)日：2024-05-28

申请号：US18045572

申请日：2022-10-11

Applicant: Altor Bioscience, LLC

Inventor： Bai Liu ,  Peter Rhode ,  Wenxin Xu ,  Hing C. Wong

IPC: A61K39/395 ,  A61K38/17 ,  A61K38/20 ,  A61K47/64 ,  A61P35/00 ,  A61K39/04 ,  C07K14/35 ,  C07K14/54 ,  C07K14/715 ,  C07K16/28 ,  C07K16/32

CPC classification number: A61K38/2086 ,  A61K38/1793 ,  A61K39/39558 ,  A61K47/6425 ,  A61P35/00 ,  A61K39/04 ,  C07K14/35 ,  C07K14/5443 ,  C07K14/7155 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/32 ,  C07K2317/732 ,  C07K2319/30 ,  C07K2319/32 ,  A61K38/2086 ,  A61K2300/00

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

公开(公告)号：US20240076354A1

公开(公告)日：2024-03-07

申请号：US18498430

申请日：2023-10-31

Applicant: Altor BioScience, LLC.

Inventor： Hing C. Wong ,  Peter Rhode ,  Bai Liu ,  Xiaoyun Zhu ,  Kai-Ping Han

IPC: C07K14/715 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  A61K45/06 ,  C07K14/54 ,  C07K16/18 ,  C07K16/28 ,  C12N15/09 ,  C12N15/62 ,  C12P21/00

CPC classification number: C07K14/7155 ,  A61K38/1793 ,  A61K38/2086 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/5443 ,  C07K16/18 ,  C07K16/2887 ,  C12N15/09 ,  C12N15/62 ,  C12P21/00 ,  A61K38/00 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/30

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor α/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

公开(公告)号：US20230248813A1

公开(公告)日：2023-08-10

申请号：US18168428

申请日：2023-02-13

Applicant: Altor Bioscience LLC

Inventor： Warren D. Marcus ,  Robert Newman ,  Bai Liu ,  Lijing You ,  Lin Kong ,  Peter Rhode ,  Hing C. Wong

IPC: A61K39/00 ,  C12N15/62 ,  C07K14/54 ,  A61K47/68 ,  C07K16/28 ,  A61P35/00 ,  C07K14/715

CPC classification number: A61K39/00114 ,  C12N15/62 ,  C07K14/5434 ,  A61K47/6811 ,  C07K16/283 ,  C07K14/5443 ,  A61P35/00 ,  C07K14/715 ,  C07K14/54 ,  C07K2319/30

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

公开(公告)号：US20230190877A1

公开(公告)日：2023-06-22

申请号：US18045572

申请日：2022-10-11

Applicant: Altor Bioscience, LLC

Inventor： Bai Liu ,  Peter Rhode ,  Wenxin Xu ,  Hing C. Wong

IPC: A61K38/20 ,  A61K39/395 ,  C07K16/28 ,  C07K16/32 ,  C07K14/54 ,  C07K14/715 ,  C07K19/00 ,  A61K39/04

CPC classification number: A61K38/2086 ,  A61K39/39558 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2887 ,  C07K16/32 ,  C07K14/5443 ,  C07K14/7155 ,  C07K19/00 ,  A61K39/04 ,  C07K2319/30 ,  C07K2317/732 ,  C07K14/35

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

公开(公告)号：US11679144B2

公开(公告)日：2023-06-20

申请号：US17825959

申请日：2022-05-26

Applicant: Altor Bioscience, LLC

Inventor： Bai Liu ,  Peter Rhode ,  Wenxin Xu ,  Hing C. Wong

IPC: A61K38/20 ,  C07K16/28 ,  C07K14/54 ,  C07K14/715 ,  C07K14/35 ,  A61K39/395 ,  C07K16/32 ,  C07K19/00 ,  A61K39/04

CPC classification number: A61K38/2086 ,  A61K39/04 ,  A61K39/39558 ,  C07K14/5443 ,  C07K14/7155 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2887 ,  C07K16/32 ,  C07K19/00 ,  C07K14/35 ,  C07K2317/732 ,  C07K2319/30 ,  A61K39/39558 ,  A61K2300/00 ,  A61K38/2086 ,  A61K2300/00

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

公开(公告)号：US20220098268A1

公开(公告)日：2022-03-31

申请号：US17422523

申请日：2020-01-15

Applicant: ALTOR BIOSCIENCE, LLC ,  The USA, as represented by the Secretary, Department of Health and Human Services

Inventor： Peter RHODE ,  Mark CONNORS ,  Stephen MIGUELES

IPC: C07K14/725 ,  A61P31/18 ,  A61K35/17

Abstract: Engineered TCR molecules specific to retroviral peptide/HLA complexes guide direct killing and/or enable robust immune responses against HIV infected cells. In a first aspect, a TCR fusion polypeptide comprises a TCR variable alpha (Vα) domain, a TCR variable beta domain (Vβ) and a TCR constant region domain (C), wherein the TCR fusion polypeptide is specific for HIV peptides.

公开(公告)号：US11168138B2

公开(公告)日：2021-11-09

申请号：US16365587

申请日：2019-03-26

Applicant: Altor Bioscience LLC

Inventor： Qiongzhen Li ,  Xiaoyun Zhu ,  Hing C. Wong

IPC: C07K14/71 ,  C07K16/28 ,  A61K39/395 ,  C07K16/24 ,  C07K14/715 ,  A61K38/17 ,  C12N15/62 ,  C12P21/00 ,  A61K38/00

Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant, a cytokine receptor or cytokine ligand, and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.

公开(公告)号：US11053299B2

公开(公告)日：2021-07-06

申请号：US16442265

申请日：2019-06-14

Applicant: Immunity Bio, Inc. ,  Altor Bioscience, LLC

Inventor： Patrick Soon-Shiong ,  Hing C. Wong ,  Peter Rhode ,  Bai Liu ,  Xiaoyun Zhu ,  Kai-Ping Han

IPC: C07K14/715 ,  C12N15/62 ,  C12P21/00 ,  C07K16/18 ,  A61K39/395 ,  C07K14/54 ,  A61K38/20 ,  C12N15/09 ,  A61K38/17 ,  A61K45/06 ,  C07K16/28 ,  A61K38/00

Abstract: Contemplated compositions and methods comprise chimeric molecule complexes that advantageously provide activating signaling to immune competent cells when bound to ALL cells. Furthermore, chimeric molecule complexes include an Fc portion to extend serum half live time and facilitate purification.

公开(公告)号：US12168680B2

公开(公告)日：2024-12-17

申请号：US18305965

申请日：2023-04-24

Applicant: Altor BioScience LLC

Inventor： Hing C. Wong ,  Peter Rhode ,  Xiaoyun Zhu ,  Kai-Ping Han

IPC: A61K38/20 ,  A61K38/17 ,  C07K14/54 ,  C07K14/715 ,  C07K14/725 ,  C07K16/28 ,  C12N15/09 ,  C12N15/62 ,  G01N33/569 ,  A61K38/00 ,  C07K16/18 ,  C12P21/00

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.