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公开(公告)号：US20200171236A1
公开(公告)日：2020-06-04
申请号：US16782532
申请日：2020-02-05
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Lawrence S. Ring
Abstract: A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.
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公开(公告)号：US20180036476A1
公开(公告)日：2018-02-08
申请号：US15544488
申请日：2016-02-17
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Lawrence S. Ring
Abstract: A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.
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公开(公告)号：US11986624B2
公开(公告)日：2024-05-21
申请号：US16489833
申请日：2018-03-09
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Erich Coiner , Alan D. Payne
IPC: A61M5/142
CPC classification number: A61M5/14248 , A61M2005/14252
Abstract: An insertion mechanism for a drug delivery device including a trocar, a housing, and a manifold in fluid communication with a fluid pathway connector and movable relative to the housing between a first manifold position adjacent to a proximal end of the housing and a second manifold position adjacent to a distal end of the housing. A hub carrying the trocar or hollow delivery needle is removably connected to the manifold, the hub being movable relative to the housing between a first hub position adjacent to the proximal end of the housing and a second hub position adjacent to the distal end of the housing. A power source is configured to generate rotational motion. A motion conversion mechanism operatively connects the power source and the hub, and is configured to convert the rotational motion into linear motion of the hub.
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公开(公告)号：US20240131263A1
公开(公告)日：2024-04-25
申请号：US18097725
申请日：2023-01-17
Applicant: AMGEN INC.
Inventor： Scott Robert Gibson , Adam B. McCullough
CPC classification number: A61M5/20 , A61M5/2033 , A61M5/31515 , A61M5/31571 , A61M5/5086 , A61M25/06
Abstract: Systems and methods for delayed delivery of a drug are disclosed. A drug delivery system may include a delivery member for insertion into a patient and a reservoir configured to receive a volume of a drug. An energy source may be activatable by the patient to actuate the reservoir to deliver the drug to the patient as a single bolus. A lockout system may be configured to have a locked state, wherein the lockout system prevents movement of the delivery member and/or activation of the energy source, and an unlocked state, wherein the lockout system permits movement of the delivery member and/or activation of the energy source. The lockout system may be configured to automatically change from the locked state to the unlocked state after a preselected time period has elapsed. An output element may generate a detectable output after the preselected time period has elapsed for notifying the patient.
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公开(公告)号：US11369736B2
公开(公告)日：2022-06-28
申请号：US16485245
申请日：2018-02-13
Applicant: AMGEN INC.
Inventor： Erich Coiner , Paul Faucher , Adam B. McCullough , Antonio Ubach
Abstract: An insertion mechanism for a wearable drug delivery device that deploys a small gauge flexible cannula with support of a coaxial rigid trocar or hollow needle. After insertion, the trocar or hollow needle is withdrawn leaving the cannula in place for drug delivery. The insertion mechanism may also include an insertion mechanism housing having a proximal and distal end, a manifold configured to fluidly connect the hollow interior of the cannula and the fluid pathway connector, and a manifold guide carrying the manifold and movable between a first position and a second position. A hub carries the trocar and is removably connected to the manifold guide. An insertion biasing member may be initially retained in an energized state between the proximal end of the insertion mechanism housing and the hub, and a retraction biasing member may be initially retained in an energized state between the hub and the manifold guide.
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Patent Agency Ranking
公开(公告)号：US20220062543A1
公开(公告)日：2022-03-03
申请号：US17419406
申请日：2020-02-11
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Paul Daniel Faucher
Abstract: A drug delivery system includes a delivery container including a container body adapted to accommodate a drug therein, a supply line, and a flow rate monitor. The delivery container further includes inlet and outlet ports and is constructed from a resilient material that exerts an urging force on the drug to expel the drug from the outlet port. The supply line is operably coupled to the outlet port to deliver the drug to a user. The flow rate monitor is operably coupled to at least one of the delivery container or the supply line and includes a digital controller, a fluid valve operably coupled to the digital controller, and a translating syringe in fluid communication with the fluid valve and operably coupled to the digital controller. The fluid valve, the translating piston, and the digital controller cooperate to regulate a flow rate of the drug.
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公开(公告)号：US20210346596A1
公开(公告)日：2021-11-11
申请号：US17277533
申请日：2019-10-15
Applicant: AMGEN INC.
Inventor： Jakob Halkjaer Pedersen , Matias Melander , Christian Plambech , Adam B. McCullough , Rasmus Ohlenschlager
Abstract: An approach for assembling a platform drug delivery device includes providing a set of base components and identifying, based on at least one desired characteristic of the platform drug delivery device, a rear sub-assembly for the drug delivery device from a group of rear sub-assemblies. The identified rear sub-assembly is selected, and a front sub-assembly is identified based on the at least one desired characteristic from a group of front sub-assemblies. The identified front-assembly is selected, and the drug delivery device is assembled using the set of base components, the rear sub-assembly, and the front sub-assembly.
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公开(公告)号：US10799630B2
公开(公告)日：2020-10-13
申请号：US15522345
申请日：2015-12-18
Applicant: AMGEN INC.
Inventor： Adam B. McCullough
Abstract: A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.
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公开(公告)号：US10583245B2
公开(公告)日：2020-03-10
申请号：US15544488
申请日：2016-02-17
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Lawrence S. Ring
Abstract: A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.
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公开(公告)号：US20170361015A1
公开(公告)日：2017-12-21
申请号：US15522345
申请日：2015-12-18
Applicant: AMGEN INC.
Inventor： Adam B. McCullough
Abstract: A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.
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