公开(公告)号：US20190256595A1

公开(公告)日：2019-08-22

申请号：US16343889

申请日：2017-10-25

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  UNIVERSITÉ DE MONTPELLIER ,  INSTITUT JEAN GODINOT ,  INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER

发明人： Armand BENSUSSAN ,  Bruno ROBERT ,  Pierre MARTINEAU ,  Myriam CHENTOUF ,  Anne MARIE-CARDINE ,  Jérôme GIUSTINIANI

IPC分类号： C07K16/28

摘要： The present invention relates to monoclonal antibodies that bind to the CD160-TM isoform. The inventors developed new monoclonal antibodies which bind to the CD160-TM isoform but dot not bind to the CD160 GPI-anchored isoform not to the CD160 soluble isoform. In particular, the antibodies of the present invention are suitable for amplifying NK cell activation and therefore cytotoxic functions NK cells.

公开(公告)号：US20190151304A1

公开(公告)日：2019-05-23

申请号：US16300328

申请日：2017-05-09

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCJAE MÉDICALE ,  UNIVERSITÉ DE ROUEN NORMANDIE ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7

发明人： Yossan-Var TAN ,  Catalina ABAD RABAT ,  Thierry VOISIN ,  Alain COUVINEAU

IPC分类号： A61K31/47 ,  A61P37/06

摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases. The inventors showed that orexin receptor antagonists have anti-inflammatory properties. Indeed, these compounds are antagonist for OX1R-mediated calcium mobilization but a full agonist for OX1R-mediated mitochondrial apoptosis, which is the mechanism involved in the improvement of resolution of inflammation observed in the models of colitis, multiple sclerosis and pancreatitis. In particular, the present invention relates to a method of treating an autoimmune inflammatory disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of at least one OX1R antagonist.

公开(公告)号：US20190092858A1

公开(公告)日：2019-03-28

申请号：US16098488

申请日：2017-05-03

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  UNIVERSITE PARIS 13 - PARIS NORD ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  INSTITUT PASTEUR

发明人： Sylvie BAY ,  Antonino NICOLETTI ,  Dominique LE GULUDEC ,  Jonathan VIGNE ,  Giuseppina CALIGIURI

IPC分类号： C07K16/28 ,  A61K51/08 ,  C07K7/06 ,  G01N33/60

摘要： Disclosed is CD31shed for use as a molecular imaging target in the molecular imaging of an inflammatory condition. Administering the radiolabeled peptide P8RI as CD31shed ligand in different rat models of inflammation indeed showed that CD31shed is present on activated cells in a quantity allowing a detectable signal, whereas the noise signal corresponding to CD31shed present on activated circulating cells and on other organs or cells not involved in inflammation was little. Also disclosed is a labeled CD31shed ligand and the use thereof as a molecular imaging agent in the molecular imaging of an inflammatory condition. The molecular imaging of inflammatory sites particularly allows determining whether a subject suffers from or is at risk of having an inflammatory condition or is at risk of recurrence of an inflammatory condition after an anti-inflammatory treatment.

公开(公告)号：US20180339022A1

公开(公告)日：2018-11-29

申请号：US16044561

申请日：2018-07-25

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) ,  UNIVERSITÉ DE VERSAILLES SAINT-QUENTIN-EN-YVELINES ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7

发明人： Alain COUVINEAU ,  Thierry VOISIN ,  Anne COUVELARD

IPC分类号： A61K38/22 ,  G01N33/566 ,  A61K31/713 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00 ,  C07K16/28 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/574 ,  A61K45/00 ,  G01N33/74

摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of hepatocellular carcinomas. In particular, the present invention relates to an OX1R agonist for use in the treatment of hepatocellular carcinomain a subject in need thereof.

公开(公告)号：US20180236271A1

公开(公告)日：2018-08-23

申请号：US15899076

申请日：2018-02-19

申请人： Cardiawave ,  Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - ,  Université Paris Diderot - Paris 7

发明人： Mickaël Tanter ,  Mathieu Pernot ,  Justine Robin

IPC分类号： A61N7/02 ,  A61B8/00 ,  A61B17/22

CPC分类号： A61N7/02 ,  A61B8/4466 ,  A61B8/485 ,  A61B17/22004 ,  A61B17/22029 ,  A61B2017/00084 ,  A61B2017/00243 ,  A61B2017/00725 ,  A61B2017/00783 ,  A61B2017/22002 ,  A61B2017/22007 ,  A61B2017/22008 ,  A61B2017/22014 ,  A61B2017/22015 ,  A61B2017/22028 ,  A61N7/00 ,  A61N2007/0004 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0069

摘要： A method and system for secure ultrasound treatment of living tissues using an ultrasound probe comprising a reflective cavity in acoustic communication with living tissues, a transducer to emit an ultrasound wave in the reflective cavity and a transducer to acquire a backscattered signal in the reflective cavity. The method comprises the steps of a) emitting a first ultrasound wave in the reflective cavity that generates a backscattered ultrasound wave in the reflective cavity, b) acquiring a backscattered signal in the reflective cavity, c) determining whether an insonification can be safely performed by computing a similarity value between the backscattered signal and a predefined reference signal, and d) if an insonification can be safely performed, treating the living tissues with a second ultrasound wave emitted in the reflective cavity. The second ultrasound wave is focused a target point of the living tissues and generates a pressure pulse resulting in cavitation at this target point

公开(公告)号：US20180177487A1

公开(公告)日：2018-06-28

申请号：US15735759

申请日：2016-06-16

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Thomas DEFFIEUX ,  Jean-Luc GENNISSON ,  Mickaël TANTER ,  Ivan COHEN ,  Mathieu PERNOT

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B8/14

CPC分类号： A61B8/4209 ,  A61B5/0077 ,  A61B5/0478 ,  A61B8/0808 ,  A61B8/0816 ,  A61B8/145 ,  A61B8/4411 ,  A61B8/4416 ,  A61B8/4461 ,  A61B8/4488 ,  A61B8/488 ,  A61B8/543 ,  A61B2503/40 ,  A61B2562/0219

摘要： The invention concerns a detecting apparatus (12) for imaging at least two areas of a brain of a subject (10), the detecting apparatus (12) comprising:—a holder comprising:—a frame (14) devoted to be cemented on the skull of the subject (10), the frame (14) delimitating an inner portion (18) which is transparent to ultrasound waves,—a removable imaging device comprising:—a platform (16) delimitating an inner space (28), the inner space (28) facing the inner portion (18),—a fixing element (30) adapted to temporary fix and lock the platform (16) to the holder,—an ultrasound probe (32), and—a moving stage (34) holding the ultrasound probe (32) and being adapted to move the ultrasound probe (32) within the inner space (28).

公开(公告)号：US20180105603A1

公开(公告)日：2018-04-19

申请号：US15565933

申请日：2016-04-12

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  UNIVERSITÉ PARIS XIII PARIS-NORD

发明人： Marie-Christine BOUTON ,  Petrus LENTING ,  Cécile DENIS ,  Olivier CHRISTOPHE

IPC分类号： C07K16/38

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/76

摘要： The present invention relates to a method and compositions for the treatment of haemorrhagic diseases.

公开(公告)号：US20180030135A1

公开(公告)日：2018-02-01

申请号：US15543739

申请日：2016-01-14

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHÉ MÉDICALE) ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  INSTITUT RÉGIONAL DU CANCER DE MONTPELLIER ,  UNIVERSITÉ DE MONTPELLIER

发明人： Alain COUVINEAU ,  Thierry VOISIN ,  Bruno ROBERT ,  Pascal NICOLE ,  Myriam CHENTOUF ,  Pierre MARTINEAU

IPC分类号： C07K16/28

CPC分类号： C07K16/286 ,  A61K39/00 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/73 ,  C07K2317/75

摘要： The present disclosure relates to human monoclonal antibodies against orexin receptor type 1 (OX1R, hyprocretin 1) and uses thereof for the treatment of cancer. The antibodies are characterized by their CDRs: NYYMN, YISGSSRNIYYADFVKG, SNYDGMDV (Heavy chain) and AGTSSDVGGSNYVS, PGKAP, SSYTYYSTRV (Light Chain)) or the CDRS having at least 50% or 70% identity with the above listed sequences.

公开(公告)号：US20180019822A1

公开(公告)日：2018-01-18

申请号：US15547830

申请日：2016-02-04

申请人： PARIS SCIENCES ET LETTRES - QUARTIER LATIN ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRI ELLES DE LA VILLE DE PARIS ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7

发明人： Sylvain Gigan ,  Florent Krzakala ,  Laurent Daudet ,  Igor Carron ,  Angélique Dremeau ,  Alaa Saade

IPC分类号： H04B10/54 ,  H04B10/40 ,  H04B10/80 ,  H04B10/61

CPC分类号： H04B10/541 ,  G06E3/005 ,  H04B10/40 ,  H04B10/61 ,  H04B10/801

摘要： The invention is related to a digital-data mixing apparatus (2), a data processing system (1) and an associated method for mixing digital-data. The digital-data mixing apparatus comprises, integrated in a housing (7), input means (8) for receiving a plurality of bits (I1 . . . In) of input digital data (4), electromagnetic emission means (9) for generating a modulated electromagnetic beam (15) wherein said input digital data (4) are converted in simultaneous modulations of the modulated electromagnetic beam (15), electromagnetic scattering means (10) for scattering the modulated electromagnetic beam (15) in a scattered electromagnetic beam (19), receiving means (11) for converting the scattered electromagnetic beam (19) in bits (O1 . . . Om) of output digital data (5), and output means (12) for providing said output digital data (5).

公开(公告)号：US20170181729A1

公开(公告)日：2017-06-29

申请号：US15325103

申请日：2015-07-17

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6) ,  UNIVERSITÉ PARIS DIDEROT - PARIS 7 ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Mickael TANTER ,  Mathieu PERNOT

IPC分类号： A61B8/08 ,  G01S7/52 ,  A61B8/00

CPC分类号： A61B8/485 ,  A61B8/0883 ,  A61B8/461 ,  A61B8/5207 ,  G01S7/52022 ,  G01S7/52042

摘要： The present invention concerns a method for obtaining a functional parameter of a muscle having a part, the method comprising the steps of: a) applying ultrasound waves to the muscle, b) collecting the ultrasound waves retrodiffused by the muscle at a plurality of times, to obtain collected ultrasound waves, c) determining a first plurality of values representative of stiffness values of one part at a first plurality of times by using the collected ultrasound waves, d) determining a second plurality of values representative of deformation values of said part at a second plurality of times by using the collected ultrasound waves, and e) deducing at least one functional parameter based on the first plurality of values and the second plurality of values. The invention also concerns a corresponding device.