公开(公告)号：US20100069629A1

公开(公告)日：2010-03-18

申请号：US12376039

申请日：2007-08-07

申请人： Nobuo Shimma ,  Hirosato Ebiike ,  Jun Ohwada ,  Hatsuo Kawada ,  Kenji Morikami ,  Mitsuaki Nakamura ,  Miyuki Yoshida ,  Nobuya Ishii ,  Masami Hasegawa ,  Shun Yamamoto ,  Kohei Koyama

发明人： Nobuo Shimma ,  Hirosato Ebiike ,  Jun Ohwada ,  Hatsuo Kawada ,  Kenji Morikami ,  Mitsuaki Nakamura ,  Miyuki Yoshida ,  Nobuya Ishii ,  Masami Hasegawa ,  Shun Yamamoto ,  Kohei Koyama

IPC分类号： C07D413/14 ,  A61P35/00

CPC分类号： C07D487/04

摘要： A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility.A compound, or pharmaceutically acceptable salt thereof, represented by formula (I): [wherein, X represents a single bond, etc.; Y represents a single bond, etc. (provided that X and Y are not simultaneously single bonds); Z represents a hydrogen atom, etc.; m represents an integer of 1 or 2; and R1 represents a cyclic substituent].

摘要翻译： 由于具有优异的PI3K抑制作用以及在体内具有优异的稳定性和水溶性，因此提供了可用作癌症的预防或治疗剂的药物。 由式（I）表示的化合物或其药学上可接受的盐：[其中，X表示单键等; Y表示单键等（X和Y不同时为单键）。 Z表示氢原子等; m表示1或2的整数; 并且R 1表示环状取代基]。

公开(公告)号：US20070249697A1

公开(公告)日：2007-10-25

申请号：US11659369

申请日：2005-08-03

申请人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

发明人： Kazutaka Tachibana ,  Haruhiko Sato ,  Masateru Ohta ,  Mitsuaki Nakamura ,  Takuya Shiraishi ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Masahiro Nagamuta ,  Hiromitsu Kawata

IPC分类号： A61K31/4164 ,  A61P5/26 ,  C07D233/00

CPC分类号： C07D233/86 ,  C07D233/76

摘要： The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, Q is A is cyano or the like; B is hydrogen, halogen, or the like; X1 and X2 are each independently selected from O and S; E is a C1-4 alkyl group; and R1, R2, R3 and R4 are each independently selected from a hydrogen atom and a C1-C6 alkyl group, and a drug, a pharmaceutical composition containing the compound, and the like.

摘要翻译： 本发明提供由式（I）表示的化合物：其中n是选自1至20的整数，Q是A是氰基等; B是氢，卤素等; X 1和X 2各自独立地选自O和S; E是C 1-4烷基; 且R 1，R 2，R 3和R 4各自独立地选自氢原子和 C 1 -C 6烷基，以及药物，含有该化合物的药物组合物等。

公开(公告)号：US07283683B1

公开(公告)日：2007-10-16

申请号：US09600936

申请日：1998-11-20

申请人： Mitsuaki Nakamura ,  Keisuke Iwasaki

发明人： Mitsuaki Nakamura ,  Keisuke Iwasaki

IPC分类号： G06K9/40 ,  G06K9/34

CPC分类号： G06T5/009 ,  G06T5/40 ,  H04N1/4072 ,  H04N1/4092

摘要： In an image processing device, in order to display an image on a display device having nonlinear gradation characteristics, first, a contrast estimation unit (37) estimates the contrast of the image represented by the image data (51) input from an image input device. Next, a luminance correction unit (38) subjects the pixel data constituting the image data (51) to a luminance conversion process on the basis of the estimated contrast and the gradation characteristics. Furthermore, the pixel data may sometimes be subjected to a sharpening process. The level of the sharpening performed for one or a plurality of character regions in the image represented by the image data (51) is higher than that for the pixel data of the pixels in remaining regions other than the character regions in the image. The image data (52) comprising the pixel data subjected to these processes is supplied to the display device. Therefore, the visibility of the image displayed on the display device can be improved.

摘要翻译： 在图像处理装置中，为了在具有非线性灰度特性的显示装置上显示图像，首先，对比度估计单元（37）首先估计由图像输入装置输入的图像数据（51）表示的图像的对比度 。 接下来，亮度校正单元（38）基于估计的对比度和灰度特性，对构成图像数据（51）的像素数据进行亮度转换处理。 此外，像素数据有时可以进行锐化处理。 在由图像数据（51）表示的图像中对一个或多个字符区域进行的锐化的电平高于除图像中的字符区域之外的剩余区域中的像素的像素数据。 包括经过这些处理的像素数据的图像数据（52）被提供给显示装置。 因此，可以提高显示在显示装置上的图像的可视性。

公开(公告)号：US20050009797A1

公开(公告)日：2005-01-13

申请号：US10499044

申请日：2002-12-19

申请人： Mitsuaki Nakamura ,  Kazutaka Tachibana ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Setsu Kawata

发明人： Mitsuaki Nakamura ,  Kazutaka Tachibana ,  Ikuhiro Imaoka ,  Hitoshi Yoshino ,  Setsu Kawata

IPC分类号： A61P5/28 ,  A61P13/08 ,  A61P15/08 ,  A61P17/08 ,  A61P17/10 ,  A61P17/14 ,  A61P35/00 ,  C07J3/00 ,  A61K31/56 ,  C07J1/00

CPC分类号： C07J3/00

摘要： A compound of Formula (I): [wherein R1 represents a lower alkyl group, X represents an oxygen atom or a methylene group, m represents an integer of 1 to 10, and n represents an integer of 0 to 5] or a salt or ester thereof; a medicament and a pharmaceutical composition comprising one or more such compounds; a method for preventing or treating a disease closely related to androgen, which comprises administering an effective amount of one or more such compounds; a kit used for such prevention or treatment; and the use of one or more such compounds for the manufacture of the medicament.

摘要翻译： 式（I）的化合物：[其中R 1表示低级烷基，X表示氧原子或亚甲基，m表示1〜10的整数，n表示0〜5的整数]或 其盐或酯; 包含一种或多种这样的化合物的药物和药物组合物; 一种预防或治疗与雄激素密切相关的疾病的方法，其包括施用有效量的一种或多种这些化合物; 用于此类预防或治疗的试剂盒; 以及使用一种或多种这样的化合物来制造药物。

公开(公告)号：US5049904A

公开(公告)日：1991-09-17

申请号：US458885

申请日：1989-12-29

申请人： Mitsuaki Nakamura ,  Itaru Kohsaka

发明人： Mitsuaki Nakamura ,  Itaru Kohsaka

IPC分类号： B41J3/50 ,  B41J2/045 ,  B41J2/055 ,  B41J2/32 ,  B41J25/34

CPC分类号： B41J25/34

摘要： A printer devised so as to function both as a thermal printer and as an ink-jet printer. The printer having a thermal printing head cartridge, an ink-jet printing head cartridge, a cartridge holder, an electronic circuit and a sensor for identifying a printing head cartridge in use. If one of the above two kinds of printing head cartridges is optionally selected and mounted on the cartridge holder, the sensor outputs a signal of identifying which one of the printing head cartridges is mounted. Receiving the signal, the electronic circuit supplies to a printing head cartridge mounted on the cartridge holder pulse currents suitable for the specific resistors installed in the printing head cartridge for making the same function as a printing head.