公开(公告)号：US20060004014A1

公开(公告)日：2006-01-05

申请号：US11157883

申请日：2005-06-21

Applicant: Matthias Hoffmann ,  Matthias Grauert ,  Thorsten Lehmann-Lintz ,  Martin Steegmaier ,  Flavio Solca ,  Norbert Redemann

Inventor： Matthias Hoffmann ,  Matthias Grauert ,  Thorsten Lehmann-Lintz ,  Martin Steegmaier ,  Flavio Solca ,  Norbert Redemann

IPC: A61K31/525 ,  C07D475/06

CPC classification number: C07D475/00

Abstract: The present invention relates to new 2-benzylaminodihydropteridinones of general formula (I) wherein the groups R1 to R7, R10 and R11 have the meanings given in the claims and specification, the isomers thereof, methods of preparing these dihydropteridinones and their use as medicaments.

Abstract translation: 本发明涉及通式（I）的新的2-苄基氨基二氢蝶啶酮，其中基团R 1至R 7，R 10和R 10， SUP> 11 具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶酮的方法及其作为药物的用途。

公开(公告)号：US08198308B2

公开(公告)日：2012-06-12

申请号：US12946069

申请日：2010-11-15

Applicant: Steffen Steurer ,  Peter Ettmayer ,  Andreas Mantoulidis ,  Ioannis Sapountzis ,  Martin Steegmaier

Inventor： Steffen Steurer ,  Peter Ettmayer ,  Andreas Mantoulidis ,  Ioannis Sapountzis ,  Martin Steegmaier

IPC: A61K31/44 ,  C07D401/00

CPC classification number: C07D417/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract translation: 本发明包括通式（1）的化合物，其中R 2至R 4，L，Q和n基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用途 用于制备具有上述性质的药物。

公开(公告)号：US20120107312A1

公开(公告)日：2012-05-03

申请号：US13342507

申请日：2012-01-03

Applicant: Gerd MUNZERT ,  Martin STEEGMAIER ,  Anke BAUM

Inventor： Gerd MUNZERT ,  Martin STEEGMAIER ,  Anke BAUM

IPC: A61K31/519 ,  A61K31/55 ,  A61P35/00 ,  A61K33/24 ,  A61K39/395 ,  A61K31/5377 ,  A61K31/7068

CPC classification number: A61K31/4985 ,  A61K31/435 ,  A61K31/4409 ,  A61K31/519

Abstract: Disclosed are pharmaceutical compositions for the treatment of diseases which involve cell proliferation. Also disclosed are methods for the treatment of said diseases, comprising co-administration of a compound 1 of Formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings given herein and of an effective amount of an active compound 2 and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of a compound 1 of Formula (I) and of an effective amount of an active compound 2 and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.

Abstract translation: 公开了用于治疗涉及细胞增殖的疾病的药物组合物。 还公开了治疗所述疾病的方法，包括共同给予式（I）的化合物1，其中基团L，R 1，R 2，R 3，R 4和R 5具有本文给出的含义和有效量的 活性化合物2和/或以放射疗法共同治疗，以提供添加剂和协同效应的比例，以及组合使用式（I）化合物1和有效量的活性化合物2和/ 或放射治疗用于制造相应的药物组合制剂。

公开(公告)号：US20110059938A1

公开(公告)日：2011-03-10

申请号：US12946069

申请日：2010-11-15

Applicant: Steffen STEURER ,  Peter ETTMAYER ,  Andreas MANTOULIDIS ,  Ioannis SAPOUNTZIS ,  Martin STEEGMAIER

Inventor： Steffen STEURER ,  Peter ETTMAYER ,  Andreas MANTOULIDIS ,  Ioannis SAPOUNTZIS ,  Martin STEEGMAIER

IPC: A61K31/4439 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/4192 ,  A61K31/422 ,  A61K31/427 ,  A61K31/454 ,  A61K31/444 ,  A61K31/506 ,  A61P35/00 ,  A61P31/00 ,  A61P37/00 ,  A61P29/00

CPC classification number: C07D417/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14

Abstract: The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Abstract translation: 本发明包括通式（1）的化合物，其中R 2至R 4，L，Q和n基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病及其用途 用于制备具有上述性质的药物。

公开(公告)号：US07786299B2

公开(公告)日：2010-08-31

申请号：US11219945

申请日：2005-09-06

Applicant: Matthias Hoffmann ,  Matthias Grauert ,  Martin Steegmaier ,  Anke Baum ,  Jens Jurgen Quant ,  Flavio Solca ,  Florian Colbatzky

Inventor： Matthias Hoffmann ,  Matthias Grauert ,  Martin Steegmaier ,  Anke Baum ,  Jens Jurgen Quant ,  Flavio Solca ,  Florian Colbatzky

IPC: C07D475/00 ,  C07D475/12 ,  C07D413/14

CPC classification number: C07D295/073 ,  C07D475/00

Abstract: Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.

Abstract translation: 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的中间体和方法及其作为药物组合物的用途。

公开(公告)号：US07759347B2

公开(公告)日：2010-07-20

申请号：US12357731

申请日：2009-01-22

Applicant: Matthias Hoffmann ,  Matthias Grauert ,  Thorsten Lehmann-Lintz ,  Martin Steegmaier ,  Flavio Solca ,  Norbert Redemann

Inventor： Matthias Hoffmann ,  Matthias Grauert ,  Thorsten Lehmann-Lintz ,  Martin Steegmaier ,  Flavio Solca ,  Norbert Redemann

IPC: A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  C07D475/00

CPC classification number: C07D475/00

Abstract: The present invention relates to new 2-benzylaminodihydropteridinones of general formula (I) wherein the groups R1 to R7, R10 and R11 have the meanings given in the claims and specification, the isomers thereof, methods of preparing these dihydropteridinones and their use as medicaments.

Abstract translation: 本发明涉及通式（I）的新的2-苄基氨基二氢蝶啶酮，其中基团R 1至R 7，R 10和R 11具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的方法及其作为药物的用途。

公开(公告)号：US20100029642A1

公开(公告)日：2010-02-04

申请号：US12578737

申请日：2009-10-14

Applicant: Matthias HOFFMANN ,  Matthias GRAUERT ,  Trixi BRANDL ,  Martin STEEGMAIER ,  Rudolf HAUPTMANN

Inventor： Matthias HOFFMANN ,  Matthias GRAUERT ,  Trixi BRANDL ,  Martin STEEGMAIER ,  Rudolf HAUPTMANN

IPC: A61K31/5377 ,  A61K31/4985 ,  A61P35/04

CPC classification number: C07D471/04

Abstract: Disclosed are pyridodihydropyrazinone compounds, processes for preparing them and their use as pharmaceutical compositions. The compounds according to the invention correspond to general formula (I), while the groups L, R1, R2, R3, R4 and R5 may have the meanings given in the claims and specification.

Abstract translation: 公开了吡啶二氢吡嗪酮化合物，其制备方法及其作为药物组合物的用途。 根据本发明的化合物对应于通式（I），而基团L，R 1，R 2，R 3，R 4和R 5可以具有权利要求书和说明书中给出的含义。

公开(公告)号：US20090149438A1

公开(公告)日：2009-06-11

申请号：US12366078

申请日：2009-02-05

Applicant: Heinz STADTMUELLER ,  Harald ENGELHARDT ,  Martin STEEGMAIER ,  Anke BAUM ,  Ulrich GUERTLER ,  Andreas SCHOOP ,  Jens Juergen QUANT ,  Flavio SOLCA ,  Rudolf HAUPTMANN ,  Ulrich REISER ,  Stephan Karl ZAHN ,  Lars HERFURTH

Inventor： Heinz STADTMUELLER ,  Harald ENGELHARDT ,  Martin STEEGMAIER ,  Anke BAUM ,  Ulrich GUERTLER ,  Andreas SCHOOP ,  Jens Juergen QUANT ,  Flavio SOLCA ,  Rudolf HAUPTMANN ,  Ulrich REISER ,  Stephan Karl ZAHN ,  Lars HERFURTH

IPC: A61K31/5377 ,  C07D413/14 ,  C07D403/12 ,  A61K31/506 ,  A61K31/551 ,  C07D409/14 ,  A61K31/553

CPC classification number: C07D239/42 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/08 ,  C07D491/10

Abstract: The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

公开(公告)号：US20090124628A1

公开(公告)日：2009-05-14

申请号：US12357731

申请日：2009-01-22

Applicant: Matthias HOFFMANN ,  Matthias GRAUERT ,  Thorsten LEHMANN-LINTZ ,  Martin STEEGMAIER ,  Flavio SOLCA ,  Norbert REDEMANN

Inventor： Matthias HOFFMANN ,  Matthias GRAUERT ,  Thorsten LEHMANN-LINTZ ,  Martin STEEGMAIER ,  Flavio SOLCA ,  Norbert REDEMANN

IPC: A61K31/495 ,  C07D475/00 ,  A61P17/14

CPC classification number: C07D475/00

Abstract: The present invention relates to new 2-benzylaminodihydropteridinones of general formula (I) wherein the groups R1 to R7, R10 and R11 have the meanings given in the claims and specification, the isomers thereof, methods of preparing these dihydropteridinones and their use as medicaments.

Abstract translation: 本发明涉及通式（I）的新的2-苄基氨基二氢蝶啶酮，其中基团R 1至R 7，R 10和R 11具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的方法及其作为药物的用途。

公开(公告)号：US07173028B2

公开(公告)日：2007-02-06

申请号：US10271763

申请日：2002-10-16

Applicant: Georg Dahmann ,  Frank Himmelsbach ,  Bernd Krist ,  Martin Lenter ,  Alexander Pautsch ,  Gisela Schnapp ,  Martin Steegmaier ,  Helmut Wittneben ,  Anthony S. Prokopowicz ,  Walter Spevak ,  Andreas Schoop ,  Steffen Steurer

Inventor： Georg Dahmann ,  Frank Himmelsbach ,  Bernd Krist ,  Martin Lenter ,  Alexander Pautsch ,  Gisela Schnapp ,  Martin Steegmaier ,  Helmut Wittneben ,  Anthony S. Prokopowicz ,  Walter Spevak ,  Andreas Schoop ,  Steffen Steurer

IPC: C07D417/10 ,  C07D239/48 ,  A61K31/506

CPC classification number: C07D239/48 ,  C07D231/12 ,  C07D233/56 ,  C07D239/50 ,  C07D239/80 ,  C07D249/08 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D451/04 ,  C07D451/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10

Abstract: The present invention relates to trisubstituted pyrimidines of formula (I) wherein 0Ra to Re are defined as in claim 1, which are suitable for the treatment of illnesses characterised by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.

Abstract translation: 本发明涉及如权利要求1所定义的式（I）的三取代嘧啶，其中R 1和R 2定义如权利要求1所述，其适用于治疗以过量为特征的疾病 或异常细胞增殖，其用于制备具有上述性质的药物组合物的用途及其制备方法。