公开(公告)号：US10709778B2

公开(公告)日：2020-07-14

申请号：US14786155

申请日：2014-04-24

Applicant: Medizinische Universität Wien

Inventor： Talin Barisani-Asenbauer ,  Aleksandra Inic-Kanada

IPC: A61K39/08 ,  A61K39/39 ,  A61K9/00 ,  A61K31/7052 ,  A61K47/06 ,  A61K39/00

Abstract: The present invention relates generally to the field of ocular therapeutics and the development thereof for use in humans and animals including mammals and birds. More particularly, it relates to subunit vaccines that are effective against pathogens causing infections thereof for use in humans and animals including mammals and birds. The present invention specifically provides a novel vaccine formulation suitable for ocular immunization comprising a subunit vaccine antigen in an amount to provoke a protective immune response and at least two adjuvants of which one is corpuscular. It further provides a method for inducing a local and systemic immune response and methods for preventing recurrence of ocular infections and/or modulates the occurrence and/or severity of sequels.

公开(公告)号：US10687711B2

公开(公告)日：2020-06-23

申请号：US15571480

申请日：2016-05-03

Applicant: Medizinische Universität Wien

Inventor： Wolf-Dieter Vogl ,  Thomas Schlegl ,  Georg Langs ,  Ursula Schmidt-Erfurth ,  Sebastian Waldstein ,  Bianca Gerendas

IPC: A61B5/00 ,  G06K9/62 ,  A61B3/10 ,  G06T7/00 ,  A61B3/00 ,  G06K9/46 ,  G06T7/11 ,  G06T7/77 ,  G06T7/143 ,  G06T7/70 ,  G06N3/04

Abstract: A computerized device for processing image data is proposed. The computerized device comprises a receiving unit a receiving unit which is configured to receive optical coherence tomography data of a tissue of a patient, in particular of a retina, a providing unit which is configured to provide a prediction model for processing the optical coherence tomography data, and a processing unit which is configured to process the received optical coherence tomography data using the prediction model for providing at least one prediction parameter for predicting prospective objects of the tissue and/or prospective features allocated to the tissue.

公开(公告)号：US10679344B2

公开(公告)日：2020-06-09

申请号：US15554414

申请日：2016-02-29

Applicant: Medizinische Universität Wien

Inventor： Thomas Schlegl ,  Wolf-Dieter Vogl ,  Georg Langs ,  Sebastian Waldstein ,  Bianca Gerendas ,  Ursula Schmidt-Erfurth

IPC: G06T7/00 ,  G06K9/62 ,  A61B3/10 ,  G06F17/15 ,  G06N3/04 ,  G06N3/08

Abstract: A computerized device for processing image data is proposed. The computerized device comprises a receiving unit which is configured to receive optical coherence tomography data of a of a tissue, in particular of a retina, a providing unit which is configured to provide a convolutional neural network for processing the optical coherence tomography data, and a processing unit which is configured to process the received optical coherence tomography data using the convolutional neural network for identifying at least one certain object in the tissue.

公开(公告)号：US20190262431A1

公开(公告)日：2019-08-29

申请号：US16307735

申请日：2017-06-09

Applicant: IMBA - INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH ,  MEDIZINISCHE UNIVERSITÄT WIEN

Inventor： Josef PENNINGER ,  Gerald WIRNSBERGER ,  Florian ZWOLANEK ,  Karl KUCHLER

IPC: A61K38/45 ,  A61K47/50 ,  C12N15/52 ,  A61P33/00 ,  A61P35/00 ,  A61P37/04 ,  A61P31/10 ,  C12N9/12 ,  A61K9/00

Abstract: The present disclosure relates to the prevention or treatment of diseases by regulating innate immunity. A Cbl-family inhibitor is provided for use in the prevention or treatment of diseases in a patient, a Cbl-family inhibitor including a binding peptide of Syk, a fusion peptide including a cell delivery portion and a Cbl-family TKB domain binding peptide, wherein the Cbl-family TKB domain binding peptide binds to the TKB domain of a Cbl-family protein, kits and uses for the same.

公开(公告)号：US20190170843A1

公开(公告)日：2019-06-06

申请号：US16323653

申请日：2017-06-09

Applicant: MEDIZINISCHE UNIVERSITÄT WIEN

Inventor： Simon Robinson ,  Korbinian Eckstein

IPC: G01R33/565 ,  A61B5/055

Abstract: The disclosed subject matter relates to a method for determining phase offsets in a complex-valued image in Magnetic Resonance Imaging, including the steps of, immobilising an object and acquiring a first image thereof at a predetermined first echo time and a second image thereof at a predetermined second echo time, the first and second images being separated into first and second magnitude images and first and second phase images, respectively, wherein a ratio between said first echo time and said second echo time is chosen to be n:(n+1), n being a positive integer; generating, pixel by pixel, a phase evolution image; and subtracting, pixel by pixel, an n-fold of the phase evolution image from the first phase image to obtain a phase offset image containing said phase offsets.

公开(公告)号：US20180354979A1

公开(公告)日：2018-12-13

申请号：US16060559

申请日：2016-12-09

Applicant: Medizinische Universität Wien ,  Universität Wien

Inventor： Christian KOWOL ,  Petra HEFFETER ,  Walter BERGER ,  Bernhard K. KEPPLER ,  Josef MAYR ,  Verena PICHLER

IPC: C07F15/00 ,  A61P35/00 ,  A61P35/02

Abstract: The present invention relates to novel monomaleimide-functionalized platinum compounds of formula (I), including in particular novel monomaleimide-functionalized oxaliplatin and carboplatin derivatives, as well as their use as medicaments, particularly for the treatment or prevention of cancer.

公开(公告)号：US20180047159A1

公开(公告)日：2018-02-15

申请号：US15554414

申请日：2016-02-29

Applicant: Medizinische Universität Wien

Inventor： Thomas Schlegl ,  Wolf-Dieter Vogl ,  Georg Langs ,  Sebastian Waldstein ,  Bianca Gerendas ,  Ursula Schmidt-Erfurth

IPC: G06T7/00 ,  G06N3/08 ,  A61B3/10 ,  G06F17/15 ,  G06N3/04

Abstract: A computerized device (100) for processing image data (OCT, RID) is proposed. The computerized device (100) comprises a receiving unit (110) which is configured to receive optical coherence tomography data (OCT) of a of a tissue, in particular of a retina, a providing unit (120) which is configured to provide a convolutional neural network (CNN) for processing the optical coherence tomography data (OCT), and a processing unit (130) which is configured to process the received optical coherence tomography data (OCT) using the convolutional neural network (CNN) for identifying at least one certain object (IRC, SRF) in the tissue.

公开(公告)号：US20160045525A1

公开(公告)日：2016-02-18

申请号：US14778850

申请日：2014-03-21

Applicant: MEDIZINISCHE UNIVERSITÄT WIEN

Inventor： Arvand Haschemi ,  Oswald Wagner ,  Csorsz Nagy ,  Rodrig Marculescu

IPC: A61K31/7004 ,  A01N1/02

CPC classification number: A61K31/7004 ,  A01N1/0226 ,  A61K45/06 ,  Y02A50/401 ,  A61K2300/00

Abstract: The invention discloses sedoheptulose for use in the prevention or treatment of inflammation.

Abstract translation: 本发明公开了用于预防或治疗炎症的镇痛剂。

公开(公告)号：US12178567B2

公开(公告)日：2024-12-31

申请号：US16972846

申请日：2019-06-07

Applicant: Technische Universität Wien ,  Medizinische Universität Wien

Inventor： Eugenijus Kaniusas ,  Klaus Ulrich Klein ,  Florian Thürk ,  Stefan Kampusch

IPC: A61B5/08 ,  A61B5/00 ,  A61B5/021 ,  A61B5/024 ,  G16H50/20 ,  G16H50/30

Abstract: The invention relates to a medical analysis device (1) for assessing a patient's suitability for anaesthesia by analysing at least one physiological biosignal (S) detected during an apnoea, wherein the medical analysis device (1) comprises the following: —an input interface (2) for detecting a time curve of at least one physiological biosignal (S) of a patient, —a computing unit (3) which is configured to compare a time curve of the at least one physiological biosignal (S) with at least one predefinable curve or a limit value according to an algorithm (4) in order to determine a patient's suitability for anaesthesia and to calculate an assessment result (E) depending thereon, wherein the time curve of the at least one physiological biosignal (S) comprises at least the duration of a patient's apnoea, and —an output interface (5) connected to the computing unit (3), to output the assessment result.

公开(公告)号：US20240287508A1

公开(公告)日：2024-08-29

申请号：US17796968

申请日：2021-02-02

Applicant: MEDIZINISCHE UNIVERSITÄT WIEN

Inventor： Franz Michael JANTSCH ,  Mamta JAIN

IPC: C12N15/11 ,  A61K38/00 ,  A61P35/00 ,  C07K14/47

CPC classification number: C12N15/111 ,  A61P35/00 ,  C07K14/47 ,  A61K38/00 ,  C12Y305/04004

Abstract: The present invention relates to the provision of new means and methods for the treatment of proliferative and inflammatory diseases. In particular, the invention relates to a pharmaceutical composition comprising a modified Filamin A encoded by a nucleic acid molecule, wherein the nucleic acid molecule is characterized in that the codon in the wildtype sequence encoding glutamine corresponding to position 2333 of SEQ ID NO: 27 is replaced by a codon encoding arginine and/or a modified Filamin B encoded by a nucleic acid molecule, wherein the nucleic acid molecule is characterized in that the codon in the wildtype sequence encoding glutamine corresponding to position 2327 of SEQ ID NO: 29 is replaced by a codon encoding arginine. The invention further relates to a pharmaceutical composition comprising a nucleic acid molecule encoding a modified Filamin A having an actin-binding domain and an arginine corresponding to the arginine at position 2333 of SEQ ID NO: 1 and/or a nucleic acid molecule encoding a modified Filamin B having an actin-binding domain and an arginine corresponding to the arginine at position 2327 of SEQ ID NO: 5. In addition, the invention provides a pharmaceutical composition comprising an oligonucleotide construct capable of modifying Filamin A RNA, wherein said modification is generated by site-directed RNA editing and comprises the conversion of adenosine corresponding to position 7247 of SEQ ID NO: 7 to inosine and/or capable of modifying Filamin B RNA, wherein said modification is generated by site-directed RNA editing and comprises the conversion of adenosine corresponding to position 7123 of SEQ ID NO: 9 to inosine.