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公开(公告)号：US10092580B2
公开(公告)日：2018-10-09
申请号：US12506091
申请日：2009-07-20
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
IPC分类号： A61K31/663 , A61K47/34 , A61K9/00 , A61K31/5513 , A61K38/17 , A61K38/29 , A61K38/39 , A61K38/47 , A61K38/48 , A61K31/66
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
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22.发明授权Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders 有权受控释放的听觉压力调节剂组合物和治疗OTIC疾病的方法公开(公告)号：US08846770B2
公开(公告)日：2014-09-30
申请号：US12486697
申请日：2009-06-17
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Durón , Michael Christopher Scaife , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Carl Lebel , Andrew M. Trammel , Jeffrey P. Harris
IPC分类号： A61K47/30 , A61K9/14 , A61K31/724
CPC分类号： A61K47/34 , A61K9/14 , A61K31/5377 , A61K31/5517 , A61K31/724
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是用于治疗耳科疾病或病症的组合物和方法，所述耳科疾病或病症具有耳神经压力调节剂组合物和通过直接将这些组合物和制剂直接施用于或经由灌注到目标物中而局部施用于患有耳科疾病或病症的个体的制剂 耳结构。
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23.发明授权Methods and compositions to generate and control the effector profile of T cells by simultaneous loading and activation of selected subsets of antigen presenting cells 有权通过同时加载和激活所选择的抗原呈递细胞亚群来产生和控制T细胞的效应子谱的方法和组合物公开(公告)号：US08809290B2
公开(公告)日：2014-08-19
申请号：US13078119
申请日：2011-04-01
IPC分类号： C12N15/117 , A61K39/12 , A61K38/02 , A61K31/713 , A61K39/145 , A61K39/39 , A61K31/7105 , A61K45/06 , A61K39/21 , A61K39/00
CPC分类号： A61K31/7105 , A61K31/713 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/385 , A61K39/39 , A61K45/06 , A61K2039/5252 , A61K2039/53 , A61K2039/544 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , A61K2039/6056 , C12N2710/20034 , C12N2740/16034 , C12N2760/16134 , A61K2300/00
摘要： The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Tc1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-γ, IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process.
摘要翻译： 本发明涉及导致对I型免疫力有效重定向于Tc1效应物的新型组合物，其利用IgG抗体主链内的肽与抗原呈递细胞的合适指示的意想不到的加载MHC I。 这样的组合物能够将看似无效的治疗剂转化成高效的治疗剂，其与产生I类限制性细胞溶解细胞和产生IFN-γ，产生IL-2的T细胞相关，进一步与防止高毒性微生物或从 恶性肿瘤过程。
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24.发明授权Controlled release compositions for modulating free-radical induced damage and methods of use thereof 有权用于调节自由基诱导的损伤的控制释放组合物及其使用方法公开(公告)号：US08784870B2
公开(公告)日：2014-07-22
申请号：US12506616
申请日：2009-07-21
申请人： Jay Lichter , Andrew M. Trammel , Fabrice Piu , Qiang Ye , Michael Christopher Scaife , Benedikt Vollrath , Sergio G. Duron , Luis A. Dellamary , Carl Lebel , Jeffrey P. Harris
发明人： Jay Lichter , Andrew M. Trammel , Fabrice Piu , Qiang Ye , Michael Christopher Scaife , Benedikt Vollrath , Sergio G. Duron , Luis A. Dellamary , Carl Lebel , Jeffrey P. Harris
IPC分类号： A61F9/02
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/06 , A61K9/122 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K9/7007 , A61K31/05 , A61K31/135 , A61K31/498 , A61K38/05 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了用于治疗耳部疾病或病症的组合物和方法，所述耳科疾病或病症具有自由基调节剂组合物和通过直接将这些组合物和制剂直接施用于灌注或通过灌注至局部给予患有耳科疾病或病症的个体的制剂 目标耳结构。
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公开(公告)号：US08709484B2
公开(公告)日：2014-04-29
申请号：US12258163
申请日：2008-10-24
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/1611 , A61K9/1617 , A61K9/1694 , A61K38/29 , A61K47/02 , A61M15/0065 , A61M2205/3306
摘要： Phospholipid based powders for drug delivery applications are disclosed. The powders may include a polyvalent cation in an amount effective to increase the gel-to-liquid crystal transition temperature of the particle compared to particles without the polyvalent cation. The powders are hollow and porous and are preferably administered via inhalation.
摘要翻译： 公开了用于药物递送应用的基于磷脂的粉末。 与没有多价阳离子的颗粒相比，粉末可以包括有效增加颗粒的凝胶 - 液晶的转变温度的多价阳离子。 粉末是中空的和多孔的，并且优选通过吸入给药。
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26.发明申请Controlled-Release CNS Modulating Compositions and Methods for the Treatment of Otic Disorders 有权控制释放CNS调节组合物和治疗眼病的方法公开(公告)号：US20120190671A1
公开(公告)日：2012-07-26
申请号：US13425217
申请日：2012-03-20
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
IPC分类号： A61K31/5513 , A61K31/195 , A61P27/16 , A61K31/16
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/00 , A61K31/167 , A61K31/195 , A61K31/197 , A61K31/5513 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/38 , A61K47/44 , A61K2300/00
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with CNS modulating agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是通过将CNS调节剂组合物和组合物局部施用于患有耳科疾病的个体，通过将这些组合物和组合物直接施用到或经由灌注到目标耳结构中来治疗耳部疾病的组合物和方法， 。
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公开(公告)号：US08080263B2
公开(公告)日：2011-12-20
申请号：US12154731
申请日：2008-05-27
IPC分类号： A61K9/12 , A61K9/00 , A61K31/56 , A61K31/135 , A61K38/28
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.
摘要翻译： 提供稳定的分散体用于递送生物活性剂。 分散体优选包括分散在通常包含液体含氟化合物的悬浮介质中的多个穿孔微结构。 随着悬浮颗粒和悬浮介质之间的密度变化被最小化，微结构之间的吸引力减弱，所公开的分散体特别地耐降解，例如通过沉降或絮凝。 在特别优选的实施方案中，稳定的分散体可以使用气管内导管或支气管镜直接施用于患者的肺。
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28.发明申请STABLE METAL ION-LIPID POWDERED PHARMACEUTICAL COMPOSITIONS FOR DRUG DELIVERY AND METHODS OF USE 有权用于药物递送的稳定的金属离子粉末药物组合物和使用方法公开(公告)号：US20110082076A1
公开(公告)日：2011-04-07
申请号：US12967482
申请日：2010-12-14
IPC分类号： A61K38/28 , C13K5/00 , A61K31/58 , A61K31/675 , A61K38/17 , A61K38/27 , A61K31/70 , A61K31/133 , A61K31/192 , A61P29/00 , A61P31/00 , C08F26/06
CPC分类号： A61K9/1617 , A61K9/0075 , A61K9/008 , A61K9/0082 , A61K9/10 , A61K9/14 , A61K9/1611 , A61K9/1694 , A61K31/465 , A61K31/496 , A61K31/58 , A61K31/7036 , A61K31/7048 , A61K38/29 , A61K45/06 , A61K47/02 , A61K47/24 , A61M15/0065 , A61M2205/3306
摘要： Microparticle compositions comprising metal ion-lipid complexes for drug delivery are described including methods of making the microparticle compositions and methods of treating certain conditions and disease states by administering the microparticle compositions. The metal ion-lipid complexes can be combined with various drugs or active agents for therapeutic administration. The microparticle compositions of the present invention have superior stability to other microparticle compositions resulting in a microparticle composition with longer shelf life and improved dispersability. The microparticle compositions of the present invention have a transition temperature (Tg) of at least 20° C. above the recommended storage temperature (Tst) for drug delivery.
摘要翻译： 描述了包含用于药物递送的金属离子 - 脂质复合物的微粒组合物，包括通过施用微粒组合物制备微粒组合物的方法和治疗某些病症和疾病状态的方法。 金属离子 - 脂质复合物可以与用于治疗性给药的各种药物或活性剂组合。 本发明的微粒组合物对其他微粒组合物具有优异的稳定性，从而得到具有更长保质期和更好分散性的微粒组合物。 本发明的微粒组合物的转移温度（Tg）比用于药物递送的推荐储存温度（Tst）高至少20℃。
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29.发明申请公开(公告)号：US20100016450A1
公开(公告)日：2010-01-21
申请号：US12506573
申请日：2009-07-21
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
IPC分类号： A61K47/30
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/06 , A61K9/122 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K9/7007 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40
摘要： Disclosed herein are delivery devices for use in the treatment of otic disorders wherein the delivery device is administered locally to an individual afflicted with an otic disorder, through direct application or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了用于治疗耳部疾病的递送装置，其中递送装置通过直接应用或通过灌注到目标耳结构而局部施用于患有耳部疾病的个体。
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30.发明申请CONTROLLED RELEASE CYTOTOXIC AGENT COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 有权受控释放的细胞毒性剂组合物和治疗情况的方法公开(公告)号：US20090324552A1
公开(公告)日：2009-12-31
申请号：US12493611
申请日：2009-06-29
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
IPC分类号： A61K35/74
CPC分类号： A61K31/00 , A61K9/0046
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with cytotoxic agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中来治疗耳科疾病或具有细胞毒性剂组合物和制剂的制剂局部施用于患有耳科疾病或病症的个体的组合物和方法 （s）。
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