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    SWALLOWING ESTIMATION DEVICE, INFORMATION TERMINAL DEVICE, AND STORAGE MEDIUM
    23.
    发明申请
    SWALLOWING ESTIMATION DEVICE, INFORMATION TERMINAL DEVICE, AND STORAGE MEDIUM 有权
    令人震惊的估计设备，信息终端设备和存储介质

    公开(公告)号：US20160143575A1

    公开(公告)日：2016-05-26

    申请号：US15011672

    申请日：2016-02-01

    Applicant: HYOGO COLLEGE OF MEDICINE ,  EuSense Medical Co., Ltd.

    Inventor： Yoshitaka OKU ,  Yoshihiko OKE

    IPC: A61B5/00 ,  A61B7/00 ,  A61B5/08

    CPC classification number: A61B5/4205 ,  A61B5/08 ,  A61B5/087 ,  A61B5/1114 ,  A61B7/00 ,  A61B7/003 ,  A61B7/008

    Abstract: A swallowing estimation device includes: a sound detection part configured to detect sound of a larynx portion; a respiration detection part configured to detect respiration; and a swallowing estimation part configured to estimate swallowing based on sound information outputted from the sound detection part and based on respiration information outputted from the respiration detection part. The swallowing estimation part obtains a value of a parameter for swallowing estimation with respect to a biological sound generation interval that corresponds to a respiratory cessation interval longer than or equal to 400 msec, and estimates whether swallowing has occurred in the biological sound generation interval based on whether the obtained value of the parameter satisfies a swallowing determination condition.

    Abstract translation: 吞咽估计装置包括：声音检测部，被配置为检测喉部的声音; 呼吸检测部，被配置为检测呼吸; 以及吞咽估计部，其基于从所述声音检测部输出的声音信息，并且基于从所述呼吸检测部输出的呼吸信息来估计吞咽。 吞咽估计部获得与对应于超过400毫秒的呼吸停止间隔的生物声音产生间隔相对应的吞咽估计参数的值，并且基于以下方式估计生物体声产生间隔中是否发生吞咽： 所获得的参数值是否满足吞咽判定条件。

    MULTI-CORRECTION ANALYSIS METHOD USING CHROMATOGRAPH
    24.
    发明公开
    MULTI-CORRECTION ANALYSIS METHOD USING CHROMATOGRAPH 审中-公开

    公开(公告)号：US20240353381A1

    公开(公告)日：2024-10-24

    申请号：US18685442

    申请日：2021-08-23

    Applicant: SHIMADZU CORPORATION ,  Hyogo College of Medicine

    Inventor： Tomonori YOKOYAMA ,  Noriyuki OJIMA ,  Reiko TANAKA ,  Shin NISHIUMI

    IPC: G01N30/86 ,  G01N30/06 ,  G01N30/72

    CPC classification number: G01N30/86 ,  G01N30/06 ,  G01N30/7206

    Abstract: A multi-correction analysis method for correcting a result of analyzing a large number of object substances contained in a sample using a chromatograph, includes: grouping at least a part of a large number of object substances possibly contained in a sample to be analyzed into groups based on changes in the measured values of the part of the object substances obtained by performing chromatographic analysis of the sample under different analysis conditions, and determining a surrogate substance for each of the groups; and adding the surrogate substance to the sample as an internal standard substance common to the object substances contained in each group, and correcting a measured value of each of the large number of object substances obtained from a result of chromatographic analysis of the sample with a measured value of the internal standard substance corresponding to the group to which the object substance belongs.

    Swallowing diagnosis apparatus and storage medium
    27.
    发明授权
    Swallowing diagnosis apparatus and storage medium 有权

    公开(公告)号：US11246526B2

    公开(公告)日：2022-02-15

    申请号：US16299405

    申请日：2019-03-12

    Applicant: OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION ,  EuSense Medical Co., Ltd. ,  HYOGO COLLEGE OF MEDICINE ,  J craft Co., Ltd.

    Inventor： Michifumi Yoshioka ,  Katsufumi Inoue ,  Yoshitaka Oku

    IPC: A61B5/00 ,  A61B5/08 ,  G06N20/10 ,  A61B5/11 ,  A61B7/00

    Abstract: A swallowing diagnosis apparatus includes a controller which enables a first swallowing determination process of determining whether or not there is an aspiration risk in the swallowing on the basis of respiratory phases before and after a period in which swallowing has been estimated as having occurred; and a second swallowing determination process of extracting reference information including at least one of the sound information and the respiration information in a predetermined period including the period in which swallowing has been estimated as having occurred, obtaining a feature quantity from the extracted reference information, and performing a machine learning process on the obtained feature quantity to determine whether or not there is a possibility of dysphagia in the swallowing; and a display control process of causing a determination result obtained by the first swallowing determination process and a determination result obtained by the second swallowing determination process to be displayed.

    NOVEL BIOMARKERS FOR CANCER IMMUNOTHERAPY
    28.
    发明申请
    NOVEL BIOMARKERS FOR CANCER IMMUNOTHERAPY 审中-公开

    公开(公告)号：US20200024349A1

    公开(公告)日：2020-01-23

    申请号：US16494228

    申请日：2018-03-14

    Applicant: Hyogo College of Medicine ,  Repertoire Genesis Incorporation

    Inventor： Seiji Matsumoto ,  Ryuji Suzuki

    IPC: C07K16/28 ,  G01N33/574

    Abstract: The present invention provides a technique for predicting an effective patient prior to starting cancer immunotherapy. The present invention provides a method of using T cell receptor (TCR) diversity of a subject as an indicator of responsiveness of the subject to cancer immunotherapy. The present invention also provides a composition for treating cancer in a subject with high TCR diversity of T cells, comprising an immune checkpoint inhibitor. The present invention is also directed to a companion medicament using such TCR diversity.

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