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公开(公告)号：US20200078589A1
公开(公告)日：2020-03-12
申请号：US16662295
申请日：2019-10-24
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.
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22.发明申请公开(公告)号：US20200038655A1
公开(公告)日：2020-02-06
申请号：US16597188
申请日：2019-10-09
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： A method for modulating a nerve within a body of a patient includes generating a single signal comprising an electrical impulse, contacting an interface with an outer skin surface of a patient and delivering the electrical impulse from an electrode through the interface and the outer skin surface of the patient to a vagus nerve, thereby modulating the vagus nerve. The electrical impulse may comprise bursts of pulses with a silent intra-burst interval between each of the bursts based on the single signal, wherein each of the bursts has a frequency of about 5 Hz to about 100 Hz and each of the pulses has a duration from about 50 microseconds to about 1000 microseconds. The electrode may be spaced from the interface by a distance of about 0.25 to about 4 times an outer dimension of the interface.
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23.发明申请公开(公告)号：US20190336764A1
公开(公告)日：2019-11-07
申请号：US16511953
申请日：2019-07-15
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico
IPC分类号： A61N1/36 , A61B5/00 , A61N1/04 , A61B5/0488
摘要： Devices, systems and methods for treating medical disorders, such as migraine or other primary headaches, or fibromyalgia, by noninvasive electrical stimulation of a vagus nerve, used in conjunction with the measurement of evoked potentials (EPs). The system comprises a stimulator that is applied to the surface of the patient's neck to apply electrical impulses sufficient to stimulate a cervical vagus nerve, scalp electrodes that are used to measure EPs that are evoked by that stimulation, feedback or biofeedback circuits to vary the stimulation based upon EP characteristics, and other sensory stimulation modalities that produce EPs. The system is preferably used to optimize the placement of the stimulator, to test whether a patient is a suitable candidate for treatment using vagus nerve stimulation, and to select the stimulation parameters that optimized acute or chronic treatment, e.g., by correcting an EP habituation deficit.
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公开(公告)号：US20190275327A1
公开(公告)日：2019-09-12
申请号：US16356639
申请日：2019-03-18
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating or preventing dementia, such as Alzheimer's disease. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve, that modulate the activity of a patient's locus ceruleus. The transmitted energy impulses, comprising magnetic and/or electrical energy, stimulate the selected nerve fibers to cause the locus ceruleus to release norepinephrine into regions of the brain that contain beta-amyloids. The norepinephrine counteracts neuroinflammation that would damage neurons in those regions and the locus ceruleus, thereby arresting or slowing the progression of the disease in the patient.
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公开(公告)号：US20190209841A1
公开(公告)日：2019-07-11
申请号：US16355306
申请日：2019-03-15
申请人： ElectroCore, Inc.
发明人： Joseph P. Errico , Steven Mendez , Bruce J. Simon
CPC分类号： A61N1/36021 , A61B5/0071 , A61B5/066 , A61B5/6898 , A61B5/7425 , A61N1/0456 , A61N1/36014 , A61N1/36025 , A61N1/37217 , A61N1/3756 , A61N1/3787 , H04M1/21 , H04M2250/12
摘要： Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.
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公开(公告)号：US12070593B2
公开(公告)日：2024-08-27
申请号：US18117542
申请日：2023-03-06
申请人： ELECTROCORE, INC
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/0456 , A61N1/36014 , A61N1/36021 , A61N1/36034 , A61N1/36053 , A61N1/40 , A61N2/008 , A61N2/02 , H04R25/305 , H04R25/505 , H04R25/70 , A61N1/36075 , A61N2/006
摘要： Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US20240278012A1
公开(公告)日：2024-08-22
申请号：US18653888
申请日：2024-05-02
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/36014 , A61N1/0456 , A61N1/40 , A61N2/006 , A61N2/008 , A61N2/02
摘要： Devices and methods are described to produce therapeutic effects in a patient by utilizing an energy source that transmits energy non-invasively to nervous tissue. A device for modulating a nerve within a body of a patient comprises a housing comprising a power supply and a signal generator for generating an electrical impulse. The electrical impulse comprises bursts of 2 to 20 pulses, wherein each of the bursts has a frequency of 15 to 50 Hz. The device further comprises first and second electrodes coupled to the housing and having a contact surface configured for contacting an outer skin surface of a neck of a user. The energy source is configured to transmit the electrical impulse from the first and second electrodes through the outer skin surface of the user to a vagus nerve.
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公开(公告)号：US20240170162A1
公开(公告)日：2024-05-23
申请号：US18392098
申请日：2023-12-21
申请人： ElectroCore, Inc.
发明人： Peter Staats , Thomas Errico , Joseph P. Errico , Bruce J. Simon
CPC分类号： G16H50/80 , A61N1/36 , A61N1/36034 , A61N1/36053 , G16B35/00 , G16H70/60
摘要： Systems and methods are provided for treating an inflammatory or allergic response associated with a replicating pathogen, such as a virus in the coronaviridae family. The methods include emitting an electrical impulse near a vagus nerve within the patient sufficient to inhibit or reduce an inflammatory or allergic response in the patient, provide relief for bronchoconstriction that results in the tightening of airways and the inability to breath without ventilator support and/or lessen the abnormal blot clotting that develops in some patients. The systems and methods are particularly useful for treating post-COVID conditions or post-acute sequelae of COVID-19 that develop in “long-haul” or COVID patients.
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公开(公告)号：US20240139508A1
公开(公告)日：2024-05-02
申请号：US18405000
申请日：2024-01-05
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/36025 , A61N1/40 , A61N2/002 , A61N2/006 , A61N2/02 , A61N1/36114
摘要： Methods and devices are provided for the non-invasive treatment of diseases or disorders, such as Alzheimer's disease, Parkinson's disease, rheumatoid arthritis (RA), multiple sclerosis, postoperative cognitive dysfunction, or postoperative delirium. A method for comprises positioning an electrode in contact with an outer skin surface of a neck of the patient and transmitting, via the electrode, an electric current transcutaneously and non-invasively through the outer skin surface of the neck of the patient to generate an electrical impulse at or near a vagus nerve within the patient. The electrical impulse comprises bursts of 2 to 20 pulses with each of the bursts comprising a frequency from about 15 Hz to about 50 Hz and with each of the pulses comprising a duration from about 20 microseconds to about 1000 microseconds.
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公开(公告)号：US20240050733A1
公开(公告)日：2024-02-15
申请号：US18492739
申请日：2023-10-23
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico
CPC分类号： A61N1/0456 , A61N1/36034 , A61N1/36053 , A61N1/40 , A61M2021/0022
摘要： Systems and methods are provided for delivering energy impulses (and/or fields) to bodily tissues. In certain aspects, the systems and methods are particularly useful for temporarily or permanently improving intelligence, learning capacity, memory retention, recall, mood, alertness and/or sleep efficiency in human beings. In certain embodiments, the methods and devices enhance neurostructural development over a period of time by increasing neurogenesis, neuronal plasticity and/or neural connectivity efficiency, and/or by improving the chemical microenvironment of the evolving neural network. In some embodiments, these enhancements may provide temporary improvement to enable an individual to, for example, accomplish a particular task while under duress, sleep deprivation, stress, anxiety or the like. In other embodiments, these changes permanently enhance the intelligence, emotional stability, and overall brain health of the treated individual.
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