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公开(公告)号：US5580547A
公开(公告)日：1996-12-03
申请号：US463425
申请日：1995-05-26
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
CPC分类号： A61Q19/04 , A61K31/70 , A61K31/7008 , A61K31/7048 , A61K45/06 , A61K8/606
摘要： A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.
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公开(公告)号：US08183222B2
公开(公告)日：2012-05-22
申请号：US12715242
申请日：2010-03-01
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。
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公开(公告)号：US20100222419A1
公开(公告)日：2010-09-02
申请号：US12709378
申请日：2010-02-19
IPC分类号： A61K31/7088 , A61P35/00
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增殖性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。
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公开(公告)号：US20090209747A1
公开(公告)日：2009-08-20
申请号：US12275089
申请日：2008-11-20
IPC分类号： A61K31/7088 , C07H21/04
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。
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公开(公告)号：US6147056A
公开(公告)日：2000-11-14
申请号：US48927
申请日：1998-03-26
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
CPC分类号： A61K31/711 , A61K31/7048 , A61K31/713
摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative or allergically mediated diseases of other epithelia and methods for reducing photoaging or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed.
摘要翻译： 治疗或预防影响上皮细胞如银屑病，白癜风，特应性皮炎或过度增生或紫外线反应性皮肤病的过度增殖性疾病或癌前病症的方法，其他上皮细胞过度增殖或过敏介导的疾病及减少光老化或预防的方法 反映或减少皮肤癌发展的可能性。
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26.发明授权Methods for enhancing melanin synthesis in melanocytes using diacyglycerols and uses thereof 失效使用二水甘油来增强黑素细胞黑色素合成的方法及其应用
公开(公告)号：US5700450A
公开(公告)日：1997-12-23
申请号：US314470
申请日：1994-09-28
CPC分类号： A61Q5/10 , A61K8/375 , A61Q19/04 , C12N5/0626 , C12N2500/36
摘要： Methods for enhancing melanin synthesis in melanocytes, thereby increasing the melanin content of melanocytes with subsequent transfer of the melanic pigments to keratinocytes resulting in increased pigmentation of vertebrate skin and hair; melanocytes with increased melanin content produced by these methods; and uses thereof are disclosed.
摘要翻译： 增强黑素细胞黑色素合成的方法，从而增加黑素细胞的黑色素含量，随后将黑色素转移至角质形成细胞，导致脊椎动物皮肤和头发色素沉着增加; 通过这些方法产生的黑色素含量增加的黑素细胞; 并公开了其用途。
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