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21.发明授权公开(公告)号：US08389490B2
公开(公告)日：2013-03-05
申请号：US12874928
申请日：2010-09-02
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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公开(公告)号：US08354385B2
公开(公告)日：2013-01-15
申请号：US12090426
申请日：2006-10-20
申请人： Maria Del Carmen Acosta Boj , Juana Gallar Martinez , Angela Sesto Yague , Carlos Belmonte Martinez , Ana Isabel Jimenez Anton , Maria Concepcion Jimenez Gomez
发明人： Maria Del Carmen Acosta Boj , Juana Gallar Martinez , Angela Sesto Yague , Carlos Belmonte Martinez , Ana Isabel Jimenez Anton , Maria Concepcion Jimenez Gomez
IPC分类号： A61K48/00
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/14
摘要： The present invention relates to methods and compositions for the treatment and/or the prevention of conditions related to high levels of expression and/or activity of the transient receptor potential vanilloid-1 (TRPV1). Amongst others, the conditions to be treated are eye conditions such as discomfort and altered sensitivity of the cornea following refractive surgery, use of contact lenses, dry eyes and diabetic retinopathy.
摘要翻译： 本发明涉及用于治疗和/或预防与瞬时受体潜在香草素-1（TRPV1）的高水平表达和/或活性有关的病症的方法和组合物。 其中，待治疗的病症是屈光手术后角膜的不适和敏感性改变等眼睛状况，使用隐形眼镜，干眼症和糖尿病性视网膜病变。
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23.发明申请公开(公告)号：US20100022623A1
公开(公告)日：2010-01-28
申请号：US12563530
申请日：2009-09-21
IPC分类号： A61K31/7088 , A61P27/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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24.发明申请公开(公告)号：US20090105175A1
公开(公告)日：2009-04-23
申请号：US12170104
申请日：2008-07-09
IPC分类号： A61K31/7105 , A61K31/713 , A61K31/7125 , A61P27/02 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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25.发明申请公开(公告)号：US20090099113A1
公开(公告)日：2009-04-16
申请号：US12170132
申请日：2008-07-09
IPC分类号： A61K31/7088 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
摘要翻译： 本发明涉及降低眼睛眼内压（IOP）的方法和组合物。 本发明的组合物包含短干扰核酸分子（siNA），包括但不限于减少与眼内液的产生或引流相关基因表达的siRNA。 本发明的组合物可用于制备用于治疗眼睛症状的药物，所述眼部病症显示增加的眼压，例如青光眼，感染，炎症，葡萄膜炎和糖尿病性视网膜病变。 本发明的方法包括向有需要的患者施用有效量的本发明的一种或多种siNA。
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26.发明授权公开(公告)号：US08258110B2
公开(公告)日：2012-09-04
申请号：US12170132
申请日：2008-07-09
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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27.发明授权公开(公告)号：US08252759B2
公开(公告)日：2012-08-28
申请号：US12170157
申请日：2008-07-09
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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公开(公告)号：US20110313016A1
公开(公告)日：2011-12-22
申请号：US11908696
申请日：2006-03-14
IPC分类号： C07H21/02 , A61P1/00 , A61P35/04 , A61P1/12 , A61P1/14 , A61P37/00 , A61P31/00 , A61K31/7105 , A61P1/04
CPC分类号： A61K31/7115 , A61K31/00 , Y02A50/486
摘要： Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also disclosed is a method of specifically targeting siNA to treat intestinal disorders by intrarectal administration of siNA compounds.
摘要翻译： 公开了用于治疗肠疾病如IBD和克罗恩病的方法和组合物。 优选的组合物包括siNA。 还公开了专门靶向siNA以通过直肠内施用siNA化合物治疗肠道疾病的方法。
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公开(公告)号：US07807650B2
公开(公告)日：2010-10-05
申请号：US11858579
申请日：2007-09-20
CPC分类号： A61K31/7115 , A61K31/00 , Y02A50/486
摘要： Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also disclosed is a method of specifically targeting siNA to treat intestinal disorders by intrarectal administration of siNA compounds.
摘要翻译： 公开了用于治疗肠疾病如IBD和克罗恩病的方法和组合物。 优选的组合物包括siNA。 还公开了专门靶向siNA以通过直肠内施用siNA化合物治疗肠道疾病的方法。
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30.发明申请公开(公告)号：US20090105176A1
公开(公告)日：2009-04-23
申请号：US12170148
申请日：2008-07-09
IPC分类号： A61K31/7105 , A61K31/713 , A61K31/7125 , A61P27/02 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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