METHOD AND APPARATUS FOR QUANTITATION OF MICROCIRCULATION

    公开(公告)号:US20220296108A1

    公开(公告)日:2022-09-22

    申请号:US17613278

    申请日:2020-01-10

    Abstract: The present disclosure relates to a method for quantitation of microcirculation in a subject, in which a functional capillary ratio is calculated from a plurality of motion images of target factors over time in a first blood stream passing through the capillaries of the subject, and to an apparatus for measuring microcirculation in a subject. The present disclosure also relates to a method for providing information on microcirculatory disorder in a subject, in which a dynamic element in target factors is analyzed from a plurality of motion images of the target factors over time in a second blood stream passing through the capillaries of the subject, and an apparatus for diagnosis of microcirculatory disorder in a subject. The present disclosure also relates to a composition for prevention or treatment of lung injury, which contains an inhibitor against the expression or activity of macrophage-1 antigen (Mac-1) in neutrophils within pulmonary capillaries and alleviates microcirculatory disorder in the lung, a screening method, and a method for providing information for diagnosis of lung injury and disorder. The composition according to an embodiment of the present disclosure can inhibit the expression or activity of macrophage-1 antigen in neutrophils within pulmonary capillaries to allow erythrocyteserythrocytes to smoothly pass through the pulmonary capillary, whereby gas exchange is increased in a subject suffering from pulmonary microcirculatory disorder and, thus, the microcirculatory disorder in the lung can be alleviated. Thus, the composition exhibits excellent effect as a composition for prevention or treatment of lung injury.

    Method and apparatus for localizing multichannel sound signal

    公开(公告)号:US11445317B2

    公开(公告)日:2022-09-13

    申请号:US14324740

    申请日:2014-07-07

    Abstract: Provided are a method and apparatus for localizing a multichannel sound signal. The method includes: obtaining a multichannel sound signal to which sense of elevation is applied by applying a first filter to an input sound signal; determining at least one frequency range of a dynamic cue according to change of a head-related transfer function (HRTF) indicating information regarding paths from a spatial location of an actual speaker to ears of an audience; and applying a second filter to at least one sound signal, corresponding to the determined at least one frequency range, of at least one channel in the multichannel sound signal to change the at least one sound signal so as to remove or to reduce the dynamic cue when the multichannel sound signal is output.

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