公开(公告)号：US2926134A

公开(公告)日：1960-02-23

申请号：US68904857

申请日：1957-10-09

申请人： UNITED STATES STEEL CORP

发明人： SIMON ALBERT W

IPC分类号： C07D333/10 ,  C10G29/28

CPC分类号： C07D333/10 ,  C10G29/28

公开(公告)号：US2694075A

公开(公告)日：1954-11-09

申请号：US25989551

申请日：1951-12-04

申请人： TEXAS CO

发明人： RUIDISCH LOUIS E ,  BOIS EASTMAN DU

IPC分类号： C07D333/10

CPC分类号： C07D333/10

公开(公告)号：US2570722A

公开(公告)日：1951-10-09

申请号：US73874147

申请日：1947-04-01

申请人： TEXAS CO

发明人： SAGER WILLIAM F

IPC分类号： C07D333/10

CPC分类号： C07D333/10

公开(公告)号：US2558508A

公开(公告)日：1951-06-26

申请号：US67740446

申请日：1946-06-17

申请人： SHELL DEV

发明人： APPLEBY WALTER G ,  SARTOR ALBIN F

IPC分类号： C07D333/10

CPC分类号： C07D333/10

公开(公告)号：US2521429A

公开(公告)日：1950-09-05

申请号：US74143247

申请日：1947-04-14

申请人： STANDARD OIL DEV CO

发明人： WADLEY EDWARD F

IPC分类号： C07D333/10

CPC分类号： C07D333/10

公开(公告)号：US2440671A

公开(公告)日：1948-05-04

申请号：US53366644

申请日：1944-05-01

申请人： PHILLIPS PETROLEUM CO

发明人： BOYD JR JAMES H

IPC分类号： C07D333/08 ,  C07D333/10

CPC分类号： C07D333/10 ,  C07D333/08

公开(公告)号：US2414631A

公开(公告)日：1947-01-21

申请号：US50977343

申请日：1943-11-10

申请人： PHILLIPS PETROLEUM CO

发明人： BOYD JR JAMES H ,  WAGNER CARY R

IPC分类号： C07D333/10

CPC分类号： C07D333/10

公开(公告)号：US20240228456A1

公开(公告)日：2024-07-11

申请号：US18557827

申请日：2022-06-13

申请人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY

发明人： Johannes SCHRANCK ,  Eric SLACK

IPC分类号： C07D401/06 ,  C07C1/207 ,  C07C41/30 ,  C07C253/30 ,  C07D213/24 ,  C07D277/22 ,  C07D307/36 ,  C07D333/10 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

CPC分类号： C07D401/06 ,  C07C1/2078 ,  C07C41/30 ,  C07C253/30 ,  C07D213/24 ,  C07D277/22 ,  C07D307/36 ,  C07D333/10 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

摘要： The invention relates to a process for synthesising organic molecules. The invention provides a process for forming an sp2-sp3 carbon-carbon bond between a first compound comprising a substituted or unsubstituted aromatic group and a second compound comprising a substituted or unsubstituted aromatic group in the presence of a catalyst, water, and a first base. The process may find use in the preparation of active pharmaceutical ingredients.

公开(公告)号：US20180275125A1

公开(公告)日：2018-09-27

申请号：US15764735

申请日：2016-09-28

申请人： Richter Life Science Development AB

发明人： Agneta RICHTER DAHLFORS ,  Andrew Benjamin LIBBERTON ,  Peter NILSSON ,  Marcus BÄCK ,  Susanne LÖFFLER ,  Hamid SHIRANI BIDABADI ,  Xiankeng CHOONG ,  Charalampos ANTYPAS

IPC分类号： G01N33/569 ,  G16H10/40 ,  G06F19/24 ,  G06F17/18 ,  G01N33/58

CPC分类号： G01N33/56911 ,  C07D333/10 ,  G01N33/582 ,  G06F16/00 ,  G06F17/18 ,  G16B40/00 ,  G16H10/40 ,  Y02A50/52 ,  Y02A50/56 ,  Y02A50/57 ,  Y02A50/59 ,  Y02A90/26

摘要： The present invention relates to a method for detection, identification, and/or quantification of one or more microbes, microbial peptides, or compounds of microbial origin, comprising the steps of: (a). contacting an object, a substance, or a sample with a luminescent conjugated oligothiophene (LCO); (b). detecting at least one signal of the luminescent conjugated oligothiophene (LCO) of a); and (c). based on said at least one detected signal in b), determining the presence, identity, and/or quantity of the one or more microbes, microbial peptides, or compounds of microbial origin on said object or in said sample. The present invention further relates to diagnostics and a method of diagnosis of microbes, microbial peptides, or compounds of microbial origin.

公开(公告)号：US20180215745A1

公开(公告)日：2018-08-02

申请号：US15851434

申请日：2017-12-21

申请人： CHDI Foundation, Inc.

发明人： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Michael Prime ,  William Mitchell ,  Naomi Went

IPC分类号： C07D413/12 ,  C07D231/56 ,  C07D215/18 ,  C07D333/06 ,  C07D241/42 ,  C07D277/24 ,  C07D277/64 ,  C07D213/46 ,  C07D307/79 ,  C07D263/56 ,  C07D261/20 ,  C07D239/74 ,  C07D237/28 ,  C07D235/08 ,  C07D217/02 ,  C07D209/08 ,  C07D407/12 ,  C07D333/28 ,  C07D333/10 ,  C07D319/18

CPC分类号： C07D413/12 ,  A61K31/343 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/47 ,  A61K31/502 ,  A61K31/517 ,  C07D209/08 ,  C07D213/46 ,  C07D215/18 ,  C07D217/02 ,  C07D231/56 ,  C07D235/08 ,  C07D237/28 ,  C07D239/74 ,  C07D241/42 ,  C07D261/20 ,  C07D263/56 ,  C07D277/24 ,  C07D277/64 ,  C07D307/79 ,  C07D319/18 ,  C07D333/06 ,  C07D333/10 ,  C07D333/28 ,  C07D407/12

摘要： Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein as a single active agent or administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.