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    Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
    14.
    发明授权
    Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy 有权
    用于产生热气泡以改善超声成像和治疗的方法和系统

    公开(公告)号：US09345910B2

    公开(公告)日：2016-05-24

    申请号：US14679494

    申请日：2015-04-06

    Applicant: Guided Therapy Systems, LLC

    Inventor： Michael H. Slayton ,  Peter G. Barthe

    IPC: A61B8/08 ,  A61N7/00 ,  A61N5/06 ,  A61N5/10 ,  A61B8/00 ,  A61B18/00

    CPC classification number: A61N7/00 ,  A61B8/4281 ,  A61B8/4472 ,  A61B8/48 ,  A61B2018/00005 ,  A61B2018/00642 ,  A61N5/0616 ,  A61N5/10 ,  A61N2007/0039 ,  A61N2007/0043 ,  A61N2007/0056 ,  A61N2007/006 ,  A61N2007/0065 ,  A61N2007/0073

    Abstract: A method and system uniquely capable of generating thermal bubbles for improved ultrasound imaging and therapy. Several embodiments of the method and system contemplates the use of unfocused, focused, or defocused acoustic energy at variable spatial and/or temporal energy settings, in the range of about 1 kHz-100 MHz, and at variable tissue depths. The unique ability to customize acoustic energy output and target a particular region of interest makes possible highly accurate and precise thermal bubble formation. In an embodiment, the energy is acoustic energy. In other embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other forms, such radio frequency electric currents (including monopolar and bipolar radio-frequency current). In an embodiment, the energy is various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling.

    Abstract translation: 一种独特地产生热气泡以改进超声成像和治疗的方法和系统。 该方法和系统的几个实施例考虑在约1kHz-100MHz的范围内和在可变组织深度处的可变空间和/或时间能量设置下使用未聚焦，聚焦或散焦的声能。 定制声能输出和瞄准特定感兴趣区域的独特能力使得高精度和精确的热气泡形成成为可能。 在一个实施例中，能量是声能。 在其他实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他形式，例如射频电流（包括单极性和双极性射频电流）。 在一个实施例中，能量是声能，电磁能和其它能量形式或诸如冷却的能量吸收器的各种组合。

    Imaging, therapy, and temperature monitoring ultrasonic method
    15.
    发明授权
    Imaging, therapy, and temperature monitoring ultrasonic method 有权
    成像，治疗和温度监测超声波法

    公开(公告)号：US09272162B2

    公开(公告)日：2016-03-01

    申请号：US13937190

    申请日：2013-07-08

    Applicant: Guided Therapy Systems, LLC

    Inventor： Michael H. Slayton ,  Peter G. Barthe

    IPC: A61B8/00 ,  A61N7/02 ,  A61B5/01 ,  A61B8/08 ,  A61B5/00 ,  A61B8/15 ,  A61B17/22

    CPC classification number: A61N7/02 ,  A61B5/01 ,  A61B5/015 ,  A61B5/4836 ,  A61B8/0833 ,  A61B8/15 ,  A61B8/5223 ,  A61B2017/22028

    Abstract: An ultrasonic system useful for providing imaging, therapy and temperature monitoring generally comprises an acoustic transducer assembly configured to enable the ultrasound system to perform the imaging, therapy and temperature monitoring functions. The acoustic transducer assembly comprises a single transducer that is operatively connected to an imaging subsystem, a therapy subsystem and a temperature monitoring subsystem. The ultrasound system may also include a display for imaging and temperature monitoring functions. Additionally, the acoustic transducer assembly can be configured to provide three-dimensional imaging, temperature monitoring or therapeutic heating through the use of adaptive algorithms and/or rotational or translational movement. Moreover, a plurality of the exemplary single transducers can be provided to facilitate enhanced treatment capabilities.

    Abstract translation: 用于提供成像，治疗和温度监测的超声系统通常包括声学换能器组件，其被配置为使超声系统能够执行成像，治疗和温度监测功能。 声换能器组件包括可操作地连接到成像子系统，治疗子系统和温度监控子系统的单个换能器。 超声系统还可以包括用于成像和温度监视功能的显示器。 此外，声换能器组件可以被配置为通过使用自适应算法和/或旋转或平移运动来提供三维成像，温度监测或治疗加热。 此外，可以提供多个示例性的单个换能器以便于增强的治疗能力。

    Methods and systems for modulating medicants using acoustic energy
    16.
    发明授权
    Methods and systems for modulating medicants using acoustic energy 有权
    使用声能调节药物的方法和系统

    公开(公告)号：US09216276B2

    公开(公告)日：2015-12-22

    申请号：US12116810

    申请日：2008-05-07

    Applicant: Michael H. Slayton ,  Peter G. Barthe ,  Inder Raj S. Makin

    Inventor： Michael H. Slayton ,  Peter G. Barthe ,  Inder Raj S. Makin

    IPC: A61M37/00 ,  A61N7/00 ,  A61N7/02 ,  A61B19/00 ,  A61B8/00

    CPC classification number: A61M37/0092 ,  A61B8/4281 ,  A61B2090/378 ,  A61M2037/0007 ,  A61M2205/3375 ,  A61N7/00 ,  A61N7/02 ,  A61N2007/0008 ,  A61N2007/0043 ,  A61N2007/0056

    Abstract: This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.

    Abstract translation: 本发明提供了能够通过使用能量来预测性地破坏膜并机械和热调节细胞和组织来增强药物递送和/或有效性的方法和系统。 在示例性实施例中，本文公开的方法和系统能够调制多层组织。 在示例性实施例中，能量是声能（例如，超声）。 在其它示例性实施例中，能量是基于光子的能量（例如，IPL，LED，激光，白光等）或其他能量形式，例如射频电流，或声能，电磁能和其他能量的各种组合 形式或能量吸收器如冷却。 首先通过扩散，循环和/或注射将药物引入感兴趣的区域。 用于增强药物递送和/或有效性的示例性系统包括控制系统，探针和显示器或指示器系统。 可以与本发明预期的超声系统可以联接和/或共同成像和/或监视。

    Method and system for ultrasound treatment with a multi-directional transducer
    17.
    发明授权
    Method and system for ultrasound treatment with a multi-directional transducer 有权
    用多向传感器进行超声处理的方法和系统

    公开(公告)号：US09114247B2

    公开(公告)日：2015-08-25

    申请号：US13294004

    申请日：2011-11-10

    Applicant: Peter G. Barthe ,  Michael H. Slayton

    Inventor： Peter G. Barthe ,  Michael H. Slayton

    IPC: A61B8/00 ,  A61N7/02 ,  A61B17/00 ,  A61B19/00 ,  A61N7/00

    CPC classification number: A61N7/022 ,  A61B8/4272 ,  A61B2017/00084 ,  A61B2090/378 ,  A61N2007/0078

    Abstract: A method and system for ultrasound treatment utilizing a multi-directional transducer to facilitate treatment, such as therapy and/or imaging or other tissue parameter monitoring, in two or more directions. In accordance with an exemplary embodiment, a multi-directional transducer comprises at least two transduction elements configured to provide for ultrasound energy, such as radiation, acoustical energy, heat energy, imaging, positional information and/or tissue parameter monitoring signals in two or more directions. The transduction elements can comprise various materials for providing ultrasound energy or radiation, such as piezoelectric materials, with and without matching layers. In addition, the transduction elements can be configured for substantially uniform, focused and/or defocused radiation patterns, as well as for single, multiple-element and/or multiple-element array configurations. In addition, an exemplary multi-directional transducer can comprise multiple elements, either side by side, stacked or in an array.

    Abstract translation: 一种利用多向换能器来促进诸如在两个或更多个方向上的治疗和/或成像或其它组织参数监测的治疗的超声治疗的方法和系统。 根据示例性实施例，多方向换能器包括至少两个换能元件，所述至少两个换能元件被配置为提供两个或更多个超声波能量，例如辐射，声能，热能，成像，位置信息和/或组织参数监测信号 方向。 转导元件可以包括用于提供超声能量或辐射的各种材料，例如具有和不具有匹配层的压电材料。 此外，转导元件可以被配置为基本上均匀的，聚焦的和/或散焦的辐射图，以及用于单个，多元件和/或多元件阵列配置。 此外，示例性多向换能器可以包括多个元件，并排，堆叠或阵列。

    Energy based hyperhidrosis treatment
    20.
    发明授权
    Energy based hyperhidrosis treatment 有权
    能量多汗症治疗

    公开(公告)号：US08932224B2

    公开(公告)日：2015-01-13

    申请号：US13950728

    申请日：2013-07-25

    Applicant: Guided Therapy Systems, LLC

    Inventor： Peter G. Barthe ,  Michael H. Slayton ,  Inder Raj Makin

    IPC: A61N7/02 ,  A61B17/32 ,  A61B18/00 ,  A61N7/00

    CPC classification number: A61N7/02 ,  A61B8/4281 ,  A61B17/320068 ,  A61B2018/00005 ,  A61N7/00 ,  A61N2007/0004 ,  A61N2007/0052 ,  A61N2007/0078

    Abstract: A method and system for energy-based (e.g., ultrasound treatment and/or other modalities) of sweat glands are provided. An exemplary method and system for targeted treatment of sweat glands can be configured in various manners, such as through use of therapy only, therapy and monitoring, imaging and therapy, or therapy, imaging, and monitoring, and/or through use of focused, unfocused, or defocused ultrasound (or other energy) through control of various spatial and temporal parameters. As a result, ablative energy can be deposited at the particular depth at which the aberrant sweat gland population is located below the skin surface.

    Abstract translation: 提供了一种用于基于能量的方法和系统（例如，超声治疗和/或其他方式）的汗腺。 用于针对性治疗汗腺的示例性方法和系统可以以各种方式配置，例如仅通过使用治疗，治疗和监测，成像和治疗，或治疗，成像和监测，和/或通过使用聚焦， 未聚焦或散焦超声（或其他能量）通过控制各种空间和时间参数。 因此，可以在异常汗腺群体位于皮肤表面下方的特定深度沉积烧蚀能量。

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