公开(公告)号：US20180067138A1

公开(公告)日：2018-03-08

申请号：US15803252

申请日：2017-11-03

Applicant: ZORA BIOSCIENCES OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2405/04 ,  G01N2405/06 ,  G01N2570/00 ,  G01N2800/324 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided is an antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

公开(公告)号：US20160320418A1

公开(公告)日：2016-11-03

申请号：US15210048

申请日：2016-07-14

Applicant: Zora Biosciences OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2570/00 ,  G01N2800/042 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/50 ,  G01N2800/70

Abstract: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided are antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

公开(公告)号：US09423406B2

公开(公告)日：2016-08-23

申请号：US14722964

申请日：2015-05-27

Applicant: Zora Biosciences OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC: G01N33/53 ,  G01N33/92

CPC classification number: G01N33/92 ,  G01N2570/00 ,  G01N2800/042 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/50 ,  G01N2800/70

Abstract: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided are antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

公开(公告)号：US20210239719A1

公开(公告)日：2021-08-05

申请号：US17177503

申请日：2021-02-17

Applicant: ZORA BIOSCIENCES OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC: G01N33/92

Abstract: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided is an antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

公开(公告)号：US20180321266A1

公开(公告)日：2018-11-08

申请号：US15834879

申请日：2017-12-07

Applicant: Zora Biosciences OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC: G01N33/92 ,  A61K31/397 ,  A61K31/366

CPC classification number: G01N33/92 ,  A61K31/366 ,  A61K31/397 ,  G01N2405/04 ,  G01N2570/00 ,  G01N2800/32 ,  G01N2800/323 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention inter alia provides a method, and use thereof, of diagnosing and/or predicting atherosclerosis or CVD by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in detecting and predicting atherosclerosis and CVD than currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating atherosclerosis or CVD. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of atherosclerosis or CVD.

公开(公告)号：US09863965B2

公开(公告)日：2018-01-09

申请号：US15210048

申请日：2016-07-14

Applicant: Zora Biosciences OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2570/00 ,  G01N2800/042 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/50 ,  G01N2800/70

Abstract: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided are antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

公开(公告)号：US09857386B2

公开(公告)日：2018-01-02

申请号：US15246851

申请日：2016-08-25

Applicant: Zora Biosciences OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC: G01N33/92 ,  A61K31/366 ,  A61K31/397

CPC classification number: G01N33/92 ,  A61K31/366 ,  A61K31/397 ,  G01N2405/04 ,  G01N2570/00 ,  G01N2800/32 ,  G01N2800/323 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention inter alia provides a method, and use thereof, of diagnosing and/or predicting atherosclerosis or CVD by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in detecting and predicting atherosclerosis and CVD than currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating atherosclerosis or CVD. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of atherosclerosis or CVD.

公开(公告)号：US20160363602A1

公开(公告)日：2016-12-15

申请号：US15249935

申请日：2016-08-29

Applicant: Zora Biosciences OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2405/00 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/50 ,  G01N2800/70 ,  H01J49/0027

Abstract: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided are antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

公开(公告)号：US20160363601A1

公开(公告)日：2016-12-15

申请号：US15246851

申请日：2016-08-25

Applicant: Zora Biosciences OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC: G01N33/92 ,  A61K31/366 ,  A61K31/397

CPC classification number: G01N33/92 ,  A61K31/366 ,  A61K31/397 ,  G01N2405/04 ,  G01N2570/00 ,  G01N2800/32 ,  G01N2800/323 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention inter alia provides a method, and use thereof, of diagnosing and/or predicting atherosclerosis or CVD by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in detecting and predicting atherosclerosis and CVD than currently utilized clinical markers. Also provided is an antibody towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating atherosclerosis or CVD. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of atherosclerosis or CVD.

公开(公告)号：US20140295467A1

公开(公告)日：2014-10-02

申请号：US14356594

申请日：2012-11-07

Applicant: ZORA BIOSCIENCES OY

Inventor： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Minna Jänis ,  Riikka Katainen ,  Kirill Tarasov

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2570/00 ,  G01N2800/042 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/50 ,  G01N2800/70

Abstract: The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided are antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

Abstract translation: 本发明尤其提供了通过检测生物样品的脂质浓度或脂质比例并将其与对照进行比较来预测严重的CVD并发症如AMI或CVD死亡的方法及其用途，并且鉴定了特异性脂质标记物 在预测这些CVD并发症方面比目前使用的临床标志物更具体和灵敏。 还提供了针对所述脂质的抗体及其用于预测，诊断，预防和/或治疗CVD并发症的用途。 本发明另外涉及包含脂质和/或其抗体的试剂盒，用于CVD并发症的预测和/或诊断。