公开(公告)号：US09700742B2

公开(公告)日：2017-07-11

申请号：US14516442

申请日：2014-10-16

Applicant: University of Washington through its Center for Communication

Inventor： Michael S. Canney ,  Michael R. Bailey ,  Lawrence A. Crum ,  Vera A. Khokhlova ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Joo Ha Hwang ,  Oleg A. Sapozhnikov

IPC: A61B18/00 ,  A61N7/02 ,  A61B17/00 ,  A61B90/00

CPC classification number: A61N7/02 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2090/374 ,  A61B2090/378

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

公开(公告)号：US09645080B2

公开(公告)日：2017-05-09

申请号：US14254611

申请日：2014-04-16

Applicant: University of Washington Through Its Center for Commercialization

Inventor： Thomas Matula ,  Andrew A. Brayman ,  Oleg A. Sapozhnikov ,  Brian MacConaghy ,  Jarred Egan Swalwell ,  Camilo Perez

IPC: G01N33/00 ,  G01N21/53 ,  G01N21/64 ,  G01N1/40 ,  B01L3/00 ,  G01N15/10

CPC classification number: G01N21/53 ,  B01L3/502723 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2400/0436 ,  G01N1/4077 ,  G01N21/6486 ,  G01N2001/4066 ,  G01N2015/1081 ,  G01N2021/6439

Abstract: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.

公开(公告)号：US10794827B2

公开(公告)日：2020-10-06

申请号：US15478953

申请日：2017-04-04

Applicant: University of Washington

Inventor： Thomas Matula ,  Andrew A. Brayman ,  Oleg A. Sapozhnikov ,  Brian MacConaghy ,  Jarred Egan Swalwell ,  Camilo Perez

IPC: G01N21/53 ,  G01N15/10 ,  G01N1/40 ,  G01N21/64 ,  B01L3/00

Abstract: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.

公开(公告)号：US20200227018A1

公开(公告)日：2020-07-16

申请号：US16740320

申请日：2020-01-10

Applicant: University of Washington

Inventor： Adam D. Maxwell ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Michael R. Bailey

IPC: G10K11/00 ,  G10K11/30 ,  G10K15/00 ,  A61B17/225 ,  G10K11/34 ,  G10K11/20 ,  G10K11/24 ,  H03H9/64

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens includes a plurality of segments. Each of the plurality of segments has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the segment.

公开(公告)号：US20200222728A1

公开(公告)日：2020-07-16

申请号：US16712680

申请日：2019-12-12

Applicant: UNIVERSITY OF WASHINGTON ,  KONINKLIJKE PHILIPS N.V., A CORPORPORATION ORGANIZED AND EXISTING UNDER THE LAWS OF KINGDOM OF THE

Inventor： Vera Khokhlova ,  Michael R. Bailey ,  Navid Farr ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  Ari Partanen ,  Oleg A. Sapozhnikov ,  George R. Schade ,  Yak-Nam Wang

IPC: A61N7/02

Abstract: An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

公开(公告)号：US10535332B2

公开(公告)日：2020-01-14

申请号：US15508841

申请日：2015-08-26

Applicant: University of Washington

Inventor： Adam D. Maxwell ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Michael R. Bailey

IPC: H01L41/09 ,  G10K11/00 ,  G10K11/30 ,  G10K15/00 ,  G10K11/20 ,  G10K11/24 ,  H03H9/64 ,  A61B17/225 ,  G10K11/34 ,  A61B17/22

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic that increases proportionally with respect to increasing azimuth angle of the segment.

公开(公告)号：US20190117243A1

公开(公告)日：2019-04-25

申请号：US16169945

申请日：2018-10-24

Applicant: University of Washington

Inventor： Tatiana Khokhlova ,  Vera Khoklova ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Adam D. Maxwell ,  Joo Ha Hwang

IPC: A61B17/22 ,  A61N7/00

Abstract: Apparatus and method for improved cavitation-induced drug delivery is disclosed. In one embodiment, a method for delivering a treatment composition to a target tissue using ultrasound includes: directing ultrasound waveforms toward the target tissue of a patient; generating ultrasound shock fronts at the target tissue of a patient; generating a cavitation inside the target tissue of a patient by the ultrasound shock front; and delivering the treatment composition to the patient. Absorption of the treatment composition by the target tissue is increased by the cavitation inside the target tissue. In some embodiments, the treatment composition may be delivered within a time period of +/−1 week from generating the cavitation.

公开(公告)号：US20190069803A1

公开(公告)日：2019-03-07

申请号：US16178518

申请日：2018-11-01

Applicant: University of Washington through its Center for Commercialization

Inventor： Michael R. Bailey ,  Wei Lu ,  Oleg A. Sapozhnikov ,  Bryan Cunitz

IPC: A61B5/06 ,  A61B8/08

Abstract: Methods, computing devices, and computer-readable medium are described herein related to producing detection signals configured to induce an excited state of an object. A computing device may receive reflection signals, where the reflection signals correspond to at least one detection signals reflected from the object. Based on the received reflection signals, a presence of the object in the excited state may be determined. Further, an output device may provide an indication of the presence of the object in the excited state.

公开(公告)号：US20150119763A1

公开(公告)日：2015-04-30

申请号：US14516442

申请日：2014-10-16

Applicant: University of Washington through its Center for Commercialization

Inventor： Michael S. Canney ,  Michael R. Bailey ,  Lawrence A. Crum ,  Vera A. Khokhlova ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Joo Ha Hwang ,  Oleg A. Sapozhnikov

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61B2017/00084 ,  A61B2018/00005 ,  A61B2090/374 ,  A61B2090/378

Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.

Abstract translation: 使用高强度聚焦超声（“HIFU”）治疗非侵入性治疗组织的方法和系统。 例如，根据本技术的实施例的非侵入性治疗组织的方法可以包括将超声源的焦平面定位在组织中的目标部位。 超声波源可被配置为发射HIFU波。 该方法还可以包括将来自超声源的超声能量脉冲向目标部位，并在组织内产生冲击波，以在毫秒内诱导目标部位的组织沸腾。 组织的沸腾至少基本上乳化组织。

公开(公告)号：US20150017678A1

公开(公告)日：2015-01-15

申请号：US14254611

申请日：2014-04-16

Applicant: University of Washington Through Its Center for Commercialization

Inventor： Thomas Matula ,  Andrew A. Brayman ,  Oleg A. Sapozhnikov ,  Brian MacConaghy

IPC: G01N1/31 ,  G01N21/53 ,  G01N21/63 ,  G01N21/64

CPC classification number: G01N21/53 ,  B01L3/502723 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2400/0436 ,  G01N1/4077 ,  G01N21/6486 ,  G01N2001/4066 ,  G01N2015/1081 ,  G01N2021/6439

Abstract: Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.

Abstract translation: 实施例通常涉及区分和/或分离样品的与样品其余部分有关的部分。 实施方案可以针对将感兴趣的细胞与细胞样品分离。 在一些实施例中，可以修改感兴趣的细胞的声阻抗。 例如，感兴趣的细胞的声学性质可以通过将气泡附着到感兴趣的细胞来修饰。 然后可以对电池样品进行声波。 感兴趣的细胞可以基于相应的位移和/或由感兴趣的细胞响应于其的体积变化而与样品的其余部分分离和/或分离。 感兴趣的细胞可以使用驻波分离并分类成流动池的分开的通道。 可选地，可以通过光源询问单元，并且通过响应于其产生的信号来区分单元。