公开(公告)号：US11988652B2

公开(公告)日：2024-05-21

申请号：US16951909

申请日：2020-11-18

申请人： Thermo Finnigan LLC

发明人： Joshua A. Silveira ,  Dale Lindseth ,  Gary A. Schultz ,  Eloy R. Wouters ,  Michael L. Poltash ,  Brandon Howard Robson

IPC分类号： G01N30/72 ,  G01N30/14 ,  G01N30/60 ,  G01N33/68 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16 ,  G01N30/02 ,  G01N30/04

CPC分类号： G01N30/7233 ,  G01N30/14 ,  G01N30/60 ,  G01N33/6848 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0436 ,  H01J49/165 ,  G01N2030/027

摘要： Packed-tip electrospray ionization (ESI) emitters for mass spectrometry are described. In one aspect an ESI emitter stores a first type of particle. A liquid chromatography (LC) column is coupled with the emitter via a junction. The LC column stores a different type of particle than the ESI emitter to facilitate better chromatographic and ESI performance.

公开(公告)号：US11892433B2

公开(公告)日：2024-02-06

申请号：US17391880

申请日：2021-08-02

申请人： Thermo Finnigan LLC

发明人： Dale Lindseth ,  Joshua A. Silveira ,  Michael L. Poltash ,  Eloy R. Wouters ,  David E. Minkler

IPC分类号： H01J49/16 ,  G01N30/72 ,  G01N30/02

CPC分类号： G01N30/7266 ,  H01J49/165 ,  G01N2030/027

摘要： An electrospray ionization system used in mass spectrometry provides for improved current measurement. The system includes a fluid union, a fluid column coupled with a first port of the fluid union, a power source coupled with the fluid union and configured to apply a voltage potential to the fluid union, and an electrospray emitter coupled with a second port of the fluid union. The power source is coupled with the first port and configured to apply the voltage potential to the first port to restrict current leakage from the fluid union. The current sensing circuit is configured to determine an electrical current flow between the power source and the at least one of the fluid union and the first port.

公开(公告)号：US11837451B2

公开(公告)日：2023-12-05

申请号：US18152684

申请日：2023-01-10

申请人： Thermo Finnigan LLC

发明人： Joshua A. Silveira ,  Michael L. Poltash ,  Wei Wei ,  Eloy R. Wouters

IPC分类号： B08B3/02 ,  H01J49/00 ,  B08B5/02 ,  B08B9/023 ,  H01J49/16 ,  B08B9/032 ,  H01J43/16

CPC分类号： H01J49/0031 ,  B08B3/02 ,  B08B5/02 ,  B08B9/023 ,  B08B9/0323 ,  H01J49/165 ,  H01J49/167 ,  B08B2203/02

摘要： A method for cleaning an electrospray emitter of a mass spectrometer comprises the steps of: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude, |V|, of a voltage applied between a counter electrode and the electrospray emitter; and (b) changing the mode of operation of the electrospray emitter from the dripping mode or the pulsating mode of operation to the stable jet mode of operation by increasing the magnitude, |V|, of the applied voltage; wherein the repetitions are performed at a predetermined frequency that depends on one or more of liquid flow rate, an emitter internal diameter, and liquid properties.